Scientific Publications / Peer Reviewed Articles

Effect of Tramiprosate in Patients with Mild-to-Moderate Alzheimer’s Disease: Exploratory Analyses of the MRI sub-group of the Alphase study. (2009) Gauthier S, Aisen PS, Ferris SH, Saumier D, Duong A, Haine D, Garceau D, Suhy J., Oh J, Lau W, Sampalis J. For the Alphase group (J Nutr Health Aging. in press)

Lessons Learned in the Use of Volumetric MRI in Therapeutic Trials in Alzheimer's Disease: The ALZHEMEDTM (Tramiprosate) Eexperience. (2009) Saumier D, Aisen PS, Gauthier S, Vellas B, Ferris SH, Duong A, Suhy J., Oh J, Lau W, Garceau D, Haine D, Sampalis J. J Nutr Health Aging. Apr;13 (4):370-2.

Neuroradiological findings in vascular dementia (2007). A. Guermazi, Y. Miaux, A. Rovira Canellas, J. Suhy, J. Pauls, R. Lopez, H. Posner. Neuroradiology Jan;49(1):1-22.

Reduced NAA in motor and non-motor brain regions in Amyotrophic Lateral Sclerosis: A cross sectional and longitudinal study (2004). R.R. Rule, J. Suhy, N. Schuff, D.F. Gelinas, R.G. Miller and M.W. Weiner. ALS and Other Motor Neuron Disorders May (11): 1–9

Biochemical and Psychiatric Predictors of Li+ Response and Toxicity in Li+-Treated Bipolar Patients (2004). B.T. Layden, N. Minadeo, J. Suhy, T. Metreger, K. Foley, G. Borge, J.W. Crayton, F.B. Bryant, and D.M. de Freitas. Bipolar Disorders 6:53-61.

Imaging in anti-angiogenesis trial: a clinical trials radiology perspective (2003). M. Kothari, A. Guermazi, D. White, J. Suhy, C. Reinhold. Br J Radiol 76: S92-S96

Spectroscopic Metabolic Abnormalities in mTLE With and Without MRI Evidence for Mesial Temporal Sclerosis Using Hippocampal Short TE MRSI (2003). S.G. Mueller, K.D. Laxer, J Suhy, R.C. Lopez, D.L Flenniken, M.W. Weiner. Epilepsia Jul: 44(7): 977-80.

Testing Competing Path Models Linking the Biochemical Variables in Red Blood Cells from Li+- Treated Bipolar Patients (2003). N. Williams, B.T. Layden, J. Suhy, T. Metreger, K.Foley, A.A. Abukhdeir, G. Borge, J. Crayton, F.B. Bryant, and D.M. de Freitas. Bipolar Disorders Oct;5(5): 320-9.

Reduced Extrahippocampal NAA in Mesial Temporal Lobe Epilepsy. (2002) S. G. Mueller, J. Suhy, K.D. Laxer, D. L. Flenniken, J. Axelrad, A. A. Capizzano, and M. W. Weiner. Epilepsia Oct;43(10):1210-6.

1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy patients. (2002) J. Suhy, K. Laxer, A.A. Capizzano, P. Vermathen, G.B. Matson, N. M. Barbaro, M. W. Weiner. Neurology, Mar 12; 58(5), p. 821-3

Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI. (2002) J. Suhy, R.G. Miller, J. Licht, N. Schuff, A.A. Maudsley, and M.W. Weiner. Neurology, Mar 12; 58(5), p. 773-9.

1H MRS comparison of white matter and lesions in primary progressive and relapsing remitting MS. (2000) J. Suhy, W.D. Rooney, D.E. Goodkin, A.A. Capizzano, B.J. Soher, A.A. Maudsley, E. Waubant, P.B. Anderson, M.W. Weiner. Multiple Sclerosis, vol 6 (3) p. 148-155.

Competition between Li+ and Mg2+ in human neuroblastoma SH-SY5Y cells: A Fluorescence and 31P NMR study. (1999) L. Amari, B. Layden, J. Nikolakopoulos, Q. Rong, D. Mota de Freitas, G. Baltazar, M.M. Castro, C.F.G.C Geraldes. Biophysical Journal, vol 76 p. 2934-2942.

7Li nuclear magnetic resonance study for the determination of Li+ properties in human neuroblastoma SH-SY5Y cells. (1998) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas, E.B. Stubbs Jr., R. Ramasamy, M.M.C.A. Castro, C.F.G.C. Geraldes. Journal of Neurochemistry, vol 71 (4) p. 1676-1684.

Comparison of the use of gel threads and microcarrier beads in Li+ transport studies of human neuroblastoma SH-SY5Y cells. (1996) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas, C.F.G.C. Geraldes. Inorganica Chimica Acta, vol 251 p. 201-205.

Book Chapters
7Li NMR study of lithium ion transport in perfused human neuroblastoma cells. (1996) C. Zachariah, J. Nikolakopoulos, D. Mota de Freitas, E.B. Stubbs Jr., M.M.C.A. Castro, C.F.G.C. Geraldes, M. Lima, C.R. Oliveira, R. Ramasamy. Lithium: Biochemical and Clinical Advances. V.Gallicchio, N.Birch (eds).Weidner Publishing Group, Chestire, CT. p.211-230.

7Li NMR study of lithium ion transport in perfused human neuroblastoma cells. (1996) M. Castro, J. Nikolakopoulos, C. Zachariah, D.M. Freitas, E.B. Stubbs Jr., C.F.G.C. Geraldes, R. Ramasamy. Metals in Biology and Medicine, vol 4. P. Collery, J. Corbella, J. Domingo, J. Etienne, J. Llobet, (eds). John Libbey Eurotext, Paris. p. 192-194.

Li+ transport properties in perfused neuronal cells by 7Li NMR spectroscopy. (1996) M. Castro, J. Nikolakopoulos, C. Zachariah, D.M. de Freitas, C.F.G.C. Geraldes, R. Ramasamy. Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment, N.D. Hadjiliadis (ed.). Kluwer Academic Publishers, Netherlands, p. 311-321.

Abstracts
Memantine treatment in patients with Alzheimer’s disease is associated with a slower right hippocampal volume loss: an open-label, multi-center trial. (2009) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. American Academy of Neurology (AAN) April 25-May 2, 2009, Seattle, WA (poster presentation)

Memantine treatment in patients with Alzheimer’s disease is associated with a slower right hippocampal volume loss: an open-label, multi-center trial. (2009) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. International Conference on Alzheimer's and Parkinson's Disease, March 11-15, 2009, Prague, Czech Republic

Memantine treatment in patients with Alzheimer’s disease is associated with a slower right hippocampal volume loss: an open-label, multi-center trial. (2009) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. American Association for Geriatric Psychiatry (AAGP) March 5-8, 2009. Honolulu (poster presentation).

Lessons Learned in the Use of volumetric MRI in Therapeutic Trials in Alzheimer's Disease: The ALZHEMEDTM (Tramiprosate) experience. (2009) D. Saumier, P. Aisen, S. Gauthier, B. Vellas, S. H. Ferris, A. Duong, J. Suhy, J. Oh, W. Lau, D. Garceau, D. Haine, J. Sampalis. Biomarker European Task Force, January 30, 2009, Oxford, United Kingdom (oral presentation)

The Effects of Donepezil on Progression of MRI Changes in Mild Cognitive Impairment (2008) N. Schuff, J. Suhy, R.S. Doody, R. Goldman, A.K. Murthy. 7th International Cogress of Neurpsychiatry December 2-6, 2008. Cancun-Riviera Maya (poster presentation)

Memantine treatment in patients with Alzheimer’s Disease is associated with a slower hippocampal volume loss: An open-label multi-center trial. (2008) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. International Conference on Alzheimer’s Disease July 26-31, 2008 Chicago (Hot Topics poster presentation).

Memantine treatment in patients with Alzheimer’s disease is associated with a slower right hippocampal volume loss: an open-label, multi-center trial. (2008) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. 1st Conference on Clinical Trials on Alzheimer’s Disease (CTAD) September 17-19, 2008 Montpellier, France (poster presentation).

Memantine treatment in patients with Alzheimer’s disease is associated with a slower right hippocampal volume loss: an open-label, multi-center trial. (2008) M.W. Weiner, S.M. Graham, R. K. Hofbauer, S.Y. Yu, S. Li, H.A. Hsu, J. Suhy, J.L. Perhach. International Society for CNS Clinical Trials and Methodology (ISCTM) October 6-7, 2008. Toronto (poster presentation).

The effects of Donepezil on Alzheimer’s Disease Progression Monitored by MRI. (2008) N. Schuff, J. Suhy, R.S. Doody, R. Goldman, A.K. Murthy. 12th Congress of the European Federation of Neurological Societies, Aug 23-26, 2008 Madrid, Spain (poster presentation).

The effects of Donepezil on Alzheimer’s Disease Progression Monitored by MRI. (2008) A.K. Murthy, N. Schuff, J. Suhy, R.S. Doody, R. Goldman. International Conference on Alzheimer’s Disease July 26-31, 2008 Chicago (poster presentation).

Comparisons between global and focal brain atrophy measurements using multi-site magnetic resonance imaging for Alzheimer’s Disease trial. (2008) W.C. Lau, J. Leong, K. Chong, J. Lee, H. Loose, S. Shargh, A. Li, J. Suhy, J. Oh. International Conference on Alzheimer’s Disease July 26-31, 2008 Chicago (poster presentation).

Reproducibility and accuracy of whole brain atrophy and hippocampal volume using multi-center MRI for Alzheimer trial. (2008) W.C. Lau, A. Li, K. Chong, J. Leong, J. Suhy, J. Oh. 10th International Hong Kong Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy, Feb 28-Mar 1, 2008 Hong Kong. (poster presentation).

Single and multi-centre DCE-MRI reproducibility in Phase I clinical Trials. (2006) N.J. Taylor, J.A. d’Arcy, S. Walker- Samuel, K.J. Lankester, D.J. Collins, B. Knowles, D.L. White, Y. Miaux, J. Suhy, A. Guermazi, J.J. Stirling, T. Wallace, D-M. Koh, A. Tang, C. Lee, G.J. Rustin, M.O. Leach, A.R. Padhani. International Society for Magnetic Resonance in Medicine, 14th Scientific Meeting and Exhibition. Session: MR as a Predictive of Response Biomarkers to Cancer Treatment (oral presentation).

1H MRSI Measurement of Longitudinal Motor Cortex Changes in ALS. (2002) R.R. Rule, J. Suhy, R.G. Miller, N. Schuff, R.C. Lopez, M.W. Weiner. The 54th Annual Meeting of the American Academy of Neurology (poster presentation).

1H MRSI Measurement of Longitudinal Motor Cortex Changes in ALS (2001) R.R. Rule, J. Suhy, R.G. Miller, N. Schuff, R.C. Lopez, M.W. Weiner. 12th International Symposium on ALS/MND (poster presentation).

“1H MRSI Predicts Surgical Outcome in Temporal Lobe Epilepsy Patients with Normal MRI.” (2001) J. Suhy, K.D. Laxer, A.A. Capizzano, P. Vermathen, G.B. Matson, N.M. Barbaro and M.W. Weiner. International Society for Magnetic Resonance in Medicine, 9th Scientific Meeting and Exhibition, Glasgow, Scotland April 23-27, 2001 (oral presentation)


“Longitudinal Corticospinal Tract Changes in ALS by 1H MRSI.” (2001) J. Suhy, R.G. Miller, N. Schuff, R. Lopez, A.A. Maudsley and M.W. Weiner. International Society for Magnetic Resonance in Medicine, 9th Scientific Meeting and Exhibition, Glasgow, Scotland April 23-27, 2001 (poster presentation)


“Frontal Lobe NAA Reductions in Temporal Lobe Epilepsy by 1H MRSI.” (2001) J. Suhy, K. D. Laxer D. Flenniken, J. Axelrad, A.A. Capizzano and M.W. Weiner. International Society for Magnetic Resonance in Medicine, 9th Scientific Meeting and Exhibition, Glasgow, Scotland April 23-27, 2001 (oral presentation)


“Regional and Tissue Specific Changes of Metabolite Concentration with Age using Short TE Multislice 1H MRSI.” (2001) D. Wiederman, N. Schuff, J. Suhy, D.J. Meyerhoff, J. Licht, M.W. Weiner. International Society for Magnetic Resonance in Medicine, 9th Scientific Meeting and Exhibition, Glasgow, Scotland April 23-27, 2001 (poster presentation)


“1H MRSI predicts surgical outcome in mri-negative temporal lobe epilepsy.”(2000) K.D. Laxer, J. Suhy, A.A. Capizzano, P. Vermathen, G.B. Matson, N.M. Barbaro, M.W. Weiner. American Epilepsy Society 54th Annual Meeting, December 2000 (oral presentation).

“1H MRSI Measurement of Early Detection and Longitudinal Changes in ALS.”(2000) J. Suhy, N. Schuff, R.G. Miller, N. Gatto, A.A. Maudsley, M.W. Weiner. International Society for Magnetic Resonance in Medicine, 8th Scientific Meeting and Exhibition, Denver, CO, April 3-7, 2000 (poster presentation).

“Detection of ALS by Proton Magnetic Resonance Imaging.”(2000) J. Suhy, N. Schuff, R.G. Miller, A.A. Maudsley, M.W. Weiner. 52nd American Academy of Neurology Annual Meeting, San Diego, CA, April 29-May 6, 2000 (oral presentation).

“Quantitation of measurement error for motor cortex NAA in ALS.”(1999) J. Suhy, N. Schuff, R.G. Miller, N. Gatto, A.A. Maudsley, M.W. Weiner. International Society for Magnetic Resonance in Medicine, 7th Scientific Meeting and Exhibition, Philadelphia, PA, May 22-28, 1999 (poster presentation).

“Comparison of primary progressive and relapsing remitting multiple sclerosis by 1H MRSI.”(1999) J. Suhy, W.D. Rooney, D.E.Goodkin, A.A. Capizzano, A.A. Maudsley, M.W. Weiner. International Society for Magnetic Resonance in Medicine, Seventh Scientific Meeting and Exhibition, Philadelphia, PA, May 22-28, 1999 (poster presentation).

“Comparison of Fluorescence, 31P NMR, and 7Li NMR Spectroscopic Methods for Investigating Li+/Mg2+ Competition for Biomolecules: Model and Cellular Systems.”(1999) Geraldes, C.F.G.C.; Castro, M.M.C.A.; Fonseca, C.; Amari, L.; Layden, B.; Nikolakopoulos, J.; Rong, Q.; Mota de Freitas, D. the Ninth International Conference on Bioinorganic Chemistry, Minneapolis, August 1999. J. Inorg. Biochem: 74, 139.

“Biochemical comparison of primary progressive and relapsing remitting multiple sclerosis by proton magnetic resonance spectroscopy.” (1998) J. Suhy, W.D. Rooney, D.E. Goodkin, A.A. Maudsley, M.W. Weiner. 34th Western Regional American Chemical Society Meeting, San Francisco, CA October 28-31, 1998 (oral presentation).

“NMR spectroscopic analysis of Li+ transport pathways in human neuroblastoma SH-SY5Y cells.”(1997) J. Nikolakopoulos, D. Mota de Freitas, C.F.G.C. Geraldes, E.B. Stubbs Jr. 8th International Conference on Bioinorganic Chemistry, Yokohama, Japan, July 27 - August 1, 1997 J. Inorg. Biochem:67, 167 (poster presentation).

“Li+ transport pathways in SH-SY5Y neuroblastoma cells by NMR spectroscopy.”(1997) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas. 213th American Chemical Society National Meeting, San Francisco, CA, April 13-17, 1997 (oral presentation).

“Competition between Li+ and Mg2+ in human neuroblastoma SH-SY5Y cells.” (1997) L.V. Amari, J. Nikolakopoulos, D. Mota de Freitas. 41st Annual Biophysical Meeting, New Orleans, Louisiana, March 2-6, 1997, Biophysical Journal, p. A202 (poster presentation).

“Biochemical properties of lithium in human neuroblastoma SH-SY5Y cells by 7Li NMR spectroscopy.”(1996) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas. Proceedings of the International Society for Magnetic Resonance in Medicine, Fourth Scientific Meeting and Exhibition, New York, NY, 1996, vol. 2, p. 1138 (poster presentation).

“7Li NMR study of lithium ion transport in human neuroblastoma cells.”(1996) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas. The 37th ENC Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 1996, p.328 (poster presentation).

“7Li NMR study of lithium ion transport in perfused human neuroblastoma cells.”(1995) J. Nikolakopoulos, C. Zachariah, D. Mota de Freitas, E.B. Stubbs Jr., M.M. Castro, C.F.G.C. Geraldes, M.C. Lima, C. Oliveira, R. Ramasamy. Malta Lithium Symposium, Malta, November 6-10, 1995, Journal of Trace and Microprobe Techniques, vol. 13, p.525 (oral presentation).