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Scientific Publications:
Schein, P.S. The Case for a New National Program
for the Development of Cancer Therapeutics. J. Clin.
Oncology 19: 3142-3153, 2001
Blanke, C.D., Kasimis, B., Schein, P., Capizzi, R.,
Kurman, M: Phase II Study of Trimetrexate, Fluorouracil,
and Leucovorin for Advanced Colorectal Cancer. Journal
of Clinical Oncology, Vol. 15, No. 3 (March), 1997:
pp 915-920.
Veach, S.R.; Schein, P.S.: Supportive care of non-hematologic
complications of cytotoxic therapy. Supportive Care
of the Cancer Patient; Chapter 3, pp 42-73; Oxford
University Press, Inc., NY, 1997.
Schein, P.S.: Carcinoma of the pancreas. Medicine
For The Practicing Physician; Ed: J Willis Hurst,
M.D. (Fourth Edition); Publisher: Appleton & Lange,
3:77-80, 1996.
Cagnoni, P.J.; Jones, R.B.; Scott I.B.; Ross, M.;
Hami, L.; Franklin, W.A.; Capizzi, R.L.; Schein, P.S.;
Shpall, E.J.: Use of Amifostine in Bone Marrow Purging.
Seminars in Oncology 23:44-48, 1996.
Capizzi, R.L.; Scheffler, B.J.; Schein, P.S.: Proteccion
hematologica frente a la quimioterapie antineoplasica
mediante la amifostina. Rev. Cancer (Madrid) 9(1):16-22,
1995.
Oster, W; Capizzi, R; Scheffler, B.J.; Schein, P.S.:
Chemo - und Radioprotektion mit Amifostin - ein Fortschritt
in der supportiven Therapie. Onkologie Service, aktuell
3/95; Publisher: Springer-Verlag Berlin, Heidelberg
1995.
Green, D.; Bensely, D.; Schein, P.: Preclinical evaluation
of WR-151327: An orally active chemotherapy protector.
Cancer Research 54:738-741, 1994.
Kalebic, T.; Schein, P.S.: Organic thiophosphate
WR-151327 suppresses expression of HIV in chronically
infected cells. AIDS Research and Human Retroviruses,
10(6), 1994.
Shpall, E.J.; Stemmer, S.M.; Hami, L.; Franklin,
W.A.; Shaw, L.; Bonner, H.S.; Bearman, S.I.; Peters,
W.P.; Bast, R.C.; McCulloch, W.; Capizzi, R.; Mitchell,
E.; Schein, P.S.; Jones, R.B.: Amifostine (WR-2721)
Shortens the Engraftment Period of 4-Hydroperoxychclophosphamide-Purged
Bone Marrow in Breast Cancer Patients Receiving High-Dose
Chemotherapy With Autologous Bone Marrow Support.
Blood 83:3132-3137, 1994.
Schein, P.S., Mattucci, L.C.; McCulloch, W.: Altretamine.
Handbook of Chemotherapy in Clinical Oncology, Second
Edition. E. Cvitkovic, J.P. Droz, J.P. Armand, S.
Khoury, eds. Scientific Communication International
Ltd., Channel Islands, 233-35, 1994.
Poplin, E.A.; LoRusso, P.D.O.; Lokich, J.J.; Gullo,
J.J.; Leming, P.D.; Schultz, J.J.; Veach, S.R.; McCulloch,
W.; Schein, P.S.: Randomized clinical trial of mitomycin-C
with or without pretreatment with WR-2721 in patients
with advanced colorectal cancer. Journal of Cancer
Chemotherapy and Pharmacology, 33: 415-419, 1994.
Capizzi, R.L.; Scheffler, B.J.; Schein, P.S.: Amifostine-mediated
protection of normal bone marrow from cytotoxic chemotherapy.
Cancer, 72(11):3495-3501, 1993.
Schein, P.S.; Calabresi, P.: Principles of patient
management. Medical Oncology, Second Edition: Basic
Principles, Principles of patient management. Eds.
Calabresi, P.; Schein, P.S.: McGraw-Hill, 225-227,
1993.
Mitchell, E.P.; Glicksman, A.S.; Schein, P.S.: Acute
and late effects of cancer therapy and their management.
Medical Oncology, Second Edition: Basic Principles,
Principles of patient management. Eds. Calabresi,
P.; Schein, P.S.: McGraw-Hill, 345-369, 1993.
Carter, S.K.; Schein, P.S.: Clinical evaluation of
new anticancer agents. Medical Oncology, Second Edition:
Basic Principles, Principles of patient management.
Eds. Calabresi, P.; Schein, P.S.: McGraw-Hill, 371-382,
1993.
Schein, P.S.; Haller, D.G.: Gastric Cancer. Medical
Oncology, Second Edition: Basic Principles, Specific
Neoplasms. Eds. Calabresi, P.; Schein, P.S.: McGraw-Hill,
671-690, 1993.
Schein, P.S.: Results of chemotherapy and radiation
therapy protection trials with WR-2721. Cancer Investigation
10:24-26, 1992.
Mitchell, E.P.; Schein, P.S.: Nitrosoureas. The Chemotherapy
Sourcebook. M. C. Perry, T. S. Satterfield, J. W.
Pine, eds. Williams & Wilkins, Baltimore, MD.
23:384-397, 1992.
Schein, P.S.: Carcinoma of the pancreas. Medicine
For The Practicing Physician (Third Edition), 3:83-86,
1992.
Coia, L.; Krigel, R.; Hanks, G.; Comis, R.; Algazy,
K.; Peter, R.; McCulloch, W.; Schein, P.S.: A Phase
I Study of WR-2721 in combination with total body
irradiation (TBI) in patients with refractory lymphoid
malignancies. International Journal of Radiation Oncology
Biology Physics 22:791-794, 1992.
Schein, P.S.: Gastrointestinal cancer: a global perspective.
Gastrointestinal Oncology. J.B. Lippincott 1:3-11,
1992.
Schein, P.S.: Gastric cancer: Approaches to adjuvant
therapy. Gastrointestinal Oncology. J.B. Lippincott
16:189-193, 1992.
Cella, D.F.; Orav, E.J.; Kornblith, A.B.; Holland,
J.C.; Silberfarb, P.M.; Lee, K.W.; Comis, R.L.; Perry,
M.; Cooper, R.; Maurer, L.H.; Hoth, D.F.; Perloff,
M.; Bloomfield, C.; McIntyre, O.R.; Leone, L.; Lesnick,
G.; Gottlieb, A.; Nissen, N.; Glicksman, A.; Henderson,
E.; Barcos, M.; Crichlow, R.; Faulkner, C.; Eaton,
W.; North, W.; Schein, P.S.; Chu, F.; King, G.; Chahinian,
P.; Tulloch, M.: Socioeconomic status and cancer survival.
Cancer and Leukemia Group B. Journal of Clinical Oncology
9(8):1500-1509, 1991.
Schein, P.S.; Scheffler, B.; McCulloch W: WR-2721:
A unique chemotherapy and radiation therapy protective
agent. Proceedings of the Fourth Annual UCI Cancer
Conference on Clinical Management of the Drug Resistant
Cancer Patient: New Options in Clinical Oncology,
A. R. Liss, New York, 1990, Clin. Oncol 33-41, 1991.
McCulloch, W.; Scheffler, B.; Schein, P.S.: New protective
agents for bone marrow in cancer therapy. Cancer Investigation
9:279-287, 1991.
Schein, P.S.; Scheffler, B.; McCulloch, W.: The role
of hexamethylmelamine in the management of ovarian
cancer. Cancer Treatment Reviews 18:67-75, 1991.
Talebian, A.H.; Bensely, D.; Ghiorghis, A.; Hammer,
C.F.; Schein, P.S.; Green, D.: Aspartato (1,2-cyclohexanediamine)platinum(II)
complexes: Synthesis and characterization; effects
of minor impurities on antitumor activity. Inorganica
Chimica Acta 179:281-287, 1991.
Talebian, A.; Green, D.; Hammer, C.F.,; McPherson,
E.; Schein, P.S.,: New sugar mitomycin C analogues:
Preparation, murine P388 antitumor activity, and leukopenia
induction. Journal of Pharmaceutical Sciences 79:1105-1108,
1990.
Talebian, A.; Schein, P.S.; Green, D.: Synthesis
and murine P388 antitumor activity of uridine mustard:
A preliminary report. Nucleosides & Nucleotides,
Marcel Dekker, Inc. 9:721-730, 1990.
Talebian, A.; Bensely, D.; Green, D.; Schein, P.S.:
Synthesis and characterization of a series of water
soluble amidomalonato(1R,2R-Cyclohexanediamine)platinum(II)
complexes. J. Coordinat. Chem. 22:165-173, 1990.
Manetta, A.; MacNeill, C.; Lyter, J.A.; Scheffler,
B.; Podczaski, E.S.; Larson, J.E.; Schein, P.: Hexamethylmelamine
as a single second-line agent in ovarian cancer. Gynecologic
Oncology 36:93-96, 1990.
Schein, P.S.: Antineoplastics, a unique group. Animal
Toxicology Studies--Their Relevance for Man 3:17-25,
Lumley, C.E., Walker, S.R., eds. CMR Workshop, September
1989, CIBA Foundation, Quay Publishing, London, 1990.
Coombes, R.C.; Schein, P.S.; Chilvers, C.E.D.; Wils,
J.; Bliss, J.M.; Beretta, G.; Rutten, A.; Amadori,
D.; Cortes-Funes, H.; Villar-Grimalt, A.; McArdle,
C.; Rauschecker, H.F.; Boven, E.; Vassilopoulos, P.;
Welvaart, K.; Ferreira, E.P.; Wiig, J.; Gisselbrecht,
C.; Rougier, P.; Palmer, A.J.: A randomised trial
comparing adjuvant fluorouracil, doxorubicin and mitomycin
with no treatment in operable gastric cancer. Journal
of Clinical Oncology 8:1362-1369, 1990.
Talebian, A.H.; Bensely, D.; Green, D.; Schein, P.S.:
Murine antitumor activity and toxicity of water soluble
platinum (II) complexes with reduced toxicity. Anticancer
Drug Design 5:37-380, 1990.
Mitchell, E.P.; Schein, P.S.: Chemotherapeutic agents.
Clinical Management of Poisoning and Drug Overdose;
W. B. Saunders Company, Philadelphia, PA; 55:976-10011990.
Schein, P.S.: Tumours, Britannica International Encyclopedia
12:35, 1988.
Schein, P.S.; editor: Decision Making in Oncology.
B. C. Decker, Inc. Toronto, Philadelphia, 1989.
Lesesne, J.B.; Rothschild, N.; Erickson, B.; Korec,
S.; Sisk, R.; Keller, J.; Arbus, M.; Woolley, P.V.;
Chiazze, L.; Schein, P.S.; Neefe, J.R.: Cancer-associated
hemolytic-uremic syndrome: Analysis of 85 cases from
a national registry. Journal of Clinical Oncology
7:781?789, 1989.
Treat, J.; Falchuk, S.C.; Woolley, P.V.; Ahlgren
J.D.; Neefe, J.R.; Smith, F.P.; Macdonald J.S.; Schein,
P.S.: Therapy of Advanced Gastric Carcinoma. American
Journal of Clinical Oncology (CCT) 12:162-168, 1989.
Schein, P.S.; Green, D.; Hammer, C.F.; McPherson,
E.; Talebian, A.: 6?Bis?(2-chloroethyl)-amino-6-deoxy-D-galactopyranose
hydrochloride: Synthesis, chemical characterization,
murine P388 antitumor activity, and bone marrow toxicity.
Journal of Pharmaceutical Science 78:918-921, 1989.
Schein, P: Chemotherapy of Gastric Cancer. Upper
GI Tract Cancer--Research Frontiers and Direction
of Progress. The 1987 Nordic Post-graduate Oncology
Seminar. Ed. Larsolof Hafström. ACTA Chirurgica
Scandinavica Supplementum 541:13-15, 1988.
Tan, K.B.; Mattern, M.R.; Boyce, R.A.; Schein, P.S.:
Unique sensitivity of nitrogen mustard-resistant human
Burkitt lymphoma cells to novobiocin. Biochem. Pharm.
37:4411-4413, 1988.
Rahman, A.; Schein, P.S.: Use of Liposomes in Cancer
Chemotherapy. Liposomes as Drug Carriers. Ed. G. Gregoriadis.
John Wiley & Sons, Ltd. 381-400, 1988.
McCabe, M.; Smith, F.P.; Macdonald, J.S.; Woolley,
P.V.; Goldberg, D.; Schein, P.S.: Efficacy of tetrahydrocannabinol
in patients refractory to standard antiemetic therapy.
Investigational New Drugs 6:243-246, 1988.
Schein, P: Locally advanced and metastatic gastric
carcinoma. Advances in Oncology 3:15-22, 1987.
Tan, K.B.; Mattern, M.R.; Boyce, R.A.; Hertzberg,
R.P.; Schein, P.S.: Elevated topoisomerase II activity
and altered chromatin in nitrogen mustard-resistant
human cells. Proceedings of the first conference on
topoisomerases in cancer chemotherapy, NCI Monogr.
4:95?98, 1987.
Tan, K.B.; Mattern, M.R.; Boyce, R.A.; Schein, P.S.:
Elevated DNA topoisomerase II activity in nitrogen
mustard-resistant human cells. Proceedings National
Academy of Science 84:7668-7671, 1987.
Ahlgren, J.D.; Smith, F.P.; Cazap, E.; Estevez, R.A.;
Marantz, A.; Woolley, P.V.; Wilcosky, T.; Stein, J.;
Schein, P. S.: FAM (5?fluorouracil, doxorubicin, and
mitomycin) plus triazinate (FAM-T) in Gastric Carcinoma:
A combined phase II trial of the Mid-Atlantic Oncology
Program and the Pan American Health Organization.
Cancer Treatment Reports 71:419-420, 1987.
Schein, P.S., Green, D., Dean, S.W., McPherson, E.:
6-[Bis(2?chloroethyl)amino]-6-deoxygalactopyranose
Hydrochloride (C6?Galactose Mustard), a new alkylating
agent with reduced bone marrow toxicity. Cancer Research
47:696-699, 1987.
Rahman, A.; Fumagalli, A.; Barbieri, B.; Schein,
P.S.; Casazza, A.M.: Antitumor and toxicity evaluation
of free doxorubicin and doxorubicin entrapped in cardiolipin
liposomes. Cancer Chemother Pharmacol 16:22-27, 1986.
Schein, P.S.; van der Hoeven, J.J.M.: Endocrine tumors.
The Cancer Chemotherapy 8, Elsevier Science, 388-394,
1986.
Schein, P.S.: Oncolipids? A possible new approach
to diagnosis of cancer. Editorial, New England Journal
of Medicine 315:1410-1411, 1986.
Greig, R.G.; Schein, P.S.: Therapy of Gastrointestinal
Cancer. Basic Science in Gastroenterology, Diseases
of the Gut. Eds. J.M. Polak; S.R. Bloom; N.A. Wright;
A.G. Butler, 321-328, 1986.
Kaiser, J.; Stockert, R.J.; Schein, P.S.; Wolkoff,
A.W.: Recognition of hepatitis B surface antigen by
the human hepatoma cell line HepG2. Transactions of
the Association of American Physicians 99:86-91, 1986.
Cazap, E.L.; Gisselbrecht, C.; Smith, F.P.; Estevez,
R.A.; Alvarez, C.A.; Lagarde, C.; Hannois, A.; Ahmed,
S.; Schein, P.S.; Woolley, P. V.: Phase II Trials
of 5-fluorouracil, doxorubicin and cisplatin (FAP)
in advanced, measurable adenocarcinoma of lung and
stomach. Cancer Treatment Reports 70:781-783, June
1986.
Mitchell, E.P.; Schein, P.S.: Contributions of Nitrosoureas
to Cancer Treatment. Cancer Treatment Reports 70:31-41,
1986.
Schein, P.S.: The current state of chemotherapy in
gastric cancer. European Journal of Surgical Oncology
12:000-000, 1986.
Goldberg, R.M.; Smith, F.P.; Ueno, W.; Ahlgren, J.D.;
Schein, P.S.: 5-fluorouracil, Adriamycin and mitomycin
(FAM) in the treatment of adenocarcinoma of unknown
primary. Journal of Clinical Oncology 4:395-399, 1986.
Perry, M.C.; Green, M.R.; Mick, R.; Schein, P.S.:
Cisplatin in patients with gastric cancer: A cancer
and leukemia group B phase II study. Cancer Treatment
Reports 70:415-416, 1986.
Schein, P.S.; Cavalli, F.: Prednimustine: The rationale
for clinical development. Seminars in Oncology 13:1-2,
1986.
Cantrell, J.E.; Green, D.; Schein, P.S.: Antitumor
activity and bone marrow toxicity of aminoglucose
mustard anticancer agents in mice. Cancer Research
46:2340-2343, 1986.
Korec, S.; Schein, P.S.; Smith, F.P.; Neefe, J.R.;
Woolley, P.V.; Goldberg, R.M.; Phillips, T.M.: Treatment
of cancer-associated hemolytic uremic syndrome with
straphylococcal Protein A immunoperfusion. Journal
of Clinical Oncology 4:210-215, 1986.
Schein, P.S.: Gastrointestinal Tumor Study Group.
Phase II studies of drug combinations in advanced
pancreatic carcinoma: fluorouracil plus doxorubicin
plus mitomycin C and two regimens of streptozotocin
plus mitomycin C plus fluorouracil. Journal of Clinical
Oncology 4:1794-1798, 1986.
Mirabelli, C.K.; Jensen, B.D.; Mattern, M.R.; Sung,
C.-M.; Mong, S.?M.; Hill, D.T.; Dean, S.W.; Schein,
P.S.; Johnson, R.K.; Crooke, S.T.: Cellular pharmacology
of u-[1,2-bis(diphenyl-phosphino) ethane] bis[(1-thio-B-D-glucopyranosato-S)gold(I)]:
a novel antitumor agent. Anti-Cancer Drug Design 1:223-234,
1986.
Greig, R.G.; Schein, P.S.: Therapy of gastrointestinal
cancer. Scandinavian J. Gastroenterol 20:9-25, 1985.
Maral, R.; Mathe, G.; Schein, P.S.; Bourut, C.; Chenu,
E.; Imbach, J.L.; Oiry, J.: CNCC, A new nitrosourea
cysteamine analogue: I. Experimental study. Drugs
Exptl. Clin. Res. 10:883-890, 1984.
Schein, P.S.: Endocrine tumors. Cancer Chemotherapy
7. Eds. H.M. Pinedo; B.A. Chabner; Elsevier, 1985.
Law, J.; Fumagalli, A.; Schein, P.S.; Rahman, A.:
Selective inhibition of cardiac cyclic nucleotide
phosphodiesterases by doxorubicin and daunorubicin.
Life Science 36:589-599, 1985.
Busch, H.; Tew, K.; Schein, P.: Molecular and cell
biology of cancer. In: Medical Oncology: Basic Principles
and Clinical Management of Cancer. Eds. Calabresi,
P.; Schein, P.; Rosenberg, S.: Macmillan, 3?40, 1985.
Schein, P.: Etiology of Cancer: Introduction. Medical
Oncology: Basic Principles and Clinical Management
of Cancer. Eds. Calabresi, P.; Schein, P.; Rosenberg,
S.: Macmillan, 61-62, 1985.
Holyoke, D.; Schein, P.: Paraneoplastic Phenomena:
Tumor markers. Medical Oncology: Basic Principles
and Clinical Management of Cancer. Eds. Calabresi,
P.; Schein, P.; Rosenberg, S.: Macmillan, 178?188,
1985.
Carter, S.; Schein, P.: Clinical evaluation of new
anticancer agents. Medical Oncology: Basic Principles
and Clinical Management of Cancer. Eds. Calabresi,
P.; Schein, P.; Rosenberg, S.: Macmillan, 392-405,
1985.
Glicksman, A.; Schein, P.: Acute and late effects
of cancer therapy. Medical Oncology: Basic Principles
and Clinical Management of Cancer. Eds. Calabresi,
P.; Schein, P.; Rosenberg, S.: Macmillan, 426?453,
1985.
Schein, P.; Levin, B.: Neoplasms of the stomach.
Medical Oncology: Basic Principles and Clinical Management
of Cancer. Eds. Calabresi, P.; Schein, P.; Rosenberg,
S.: Macmillan, 806-827, 1985.
Schein, P.; Levin, B.: Neoplasms of the pancreas.
Medical Oncology: Basic Principles and Clinical Management
of Cancer. Eds. Calabresi, P.; Schein, P.; Rosenberg,
S.: Macmillan, 828-850, 1985.
Vu, V.T.; Moy, B.C.; Schein, P.S.; Tew, K.D.: Enhanced
nitrosourea cytotoxicity in cell culture by sodium
butyrate. Oncology 42:317-321, 1985.
Schein, P.S.: Hemolytic anemia, thrombocylopenia
and renal failure in a patient apparently cured of
anal carcinoma (Clinicopathological Conference at
Memorial Hospital). Cancer Investigation 3:481-489,
1985.
Neefe, J.R.; Silgals, R.; Ayoob, M.; Schein, P.S.:
Minimal activity of recombinant clone A interferon
in metastatic colon cancer. Journal of Biological
Response Modifiers 3:366-370, 1984.
Schein, P.S.; Coombes, R.C.; Chilvers, C.: Adjuvant
therapy of gastric and pancreatic cancer. Proceedings
14th International Cancer Congress, 1985.
Schein, P.S.; et al: Phase II trials of maytansine,
low-dose chlorozotocin, and high-dose chlorozotocin
as single agents against advanced measurable adenocarcinoma
of the pancreas. Gastrointestinal Tumor Study Group.
Cancer Treatment Reports 69:417-420, 1985.
Schein, P.S.; Green D.; McPherson, E.: Evaluation
of 6-[Bis(2?chloroethyl)amino]-6-deoxygalactopyranose
hydro-chloride (C6-GalM), a new alkylating agent with
reduced bone marrow toxicity. Proceedings of the 14th
Int'l Congress of Chemotherapy, Kyoto, 1985. (Reprinted
from: Recent Advances in Chemotherapy) 469-470, 1985.
Dean, S.W.; Tew, K.D.; Clark, A.E.; Schein, P.S.:
DNA repeat length in chromatin from murine bone marrow
and L1210 leukaemia cells. Br. J. Cancer 52:377-382,
1985.
Schein, P.S.: The role of chemotherapy in the management
of gastric and pancreatic carcinomas. Seminars In
Oncology, 12:49-60, 1985.
Schein, P.S., et al: Prolongation of the Disease-Free
Interval in Surgically Treated Rectal Carcinoma, Gastrointestinal
Tumor Study Group. New England Journal of Medicine
312:1465-1472, 1985.
Schein, P.S.; Green, D.; McPherson, E.: Evaluation
of 6-[Bis(2-chloroethyl) amino]-6-deoxygalactopyranose
hydro-chloride (C6-GalM), a new aklylating agent with
reduced bone marrow toxicity. Proceedings 14th International
Congress of Chemotherapy. Recent Advances in Chemotherapy,
Anticancer Section, University of Tokyo Press, 469-470,
1985.
McPherson, E.; Green, D.; Mallon, R.; Schein, P.S.:
Antitumor Activity and Toxicity Studies of a New Mitomycin
Analog. Proceedings 14th International Congress of
Chemotherapy. Recent Advances in Chemotherapy, Anticancer
Section, University of Tokyo Press, 566-567, 1985.
Schein, P.S.; Wolkoff, A.W.; Allegra, J.: Management
of breast cancer (software) in Clinical Oncology.
Ed. Philip S. Schein, Allan W. Wolkoff. Grune &
Stratton, New York, 1985.
Schein, P.S.: Clinical Trials in Gastric and Colorectal
Carcinoma. Clinical Trials in Cancer Medicine. Eds.
Umberto Veronesi; Gianni Bonadonna: Academic Press
3:439-460, 1985.
Cantrell, J.E.; Phillips, T.M.; Schein, P.S.: Carcinoma-Associated
Hemolytic-Uremic Syndrome: A Complication of Mitomycin-C
Chemotherapy. Journal of Clinical Oncology 3:723-734,
1985.
Schein, P.S.: Trials in gastric and colorectal carcinoma.
Clinical Trials in Cancer: Past Achievements and Future
Prospects, Academic Press, 439-459, 1985.
Schein, P.S.: Biologic effects of tumors. Cecil's
Textbook of Medicine. Eds. J.B. Wyngaarden & L.H.
Smith, Jr.; W.B. Saunders, Philadelphia; 171:1073-1074,
1985.
Schein, P.S.: Tumor markers. Cecil's Textbook of
Medicine. Eds. J.B. Wyngaarden & L.H. Smith, Jr.;
W.B. Saunders, Philadelphia; 172:1075-1077, 1985.
Wang, A.L.; Schein, P.S.: Pharmacology of nitrosourea
anticancer agents. Cancer Chemotherapy and Selective
Drug Development 71-75.
Le Chevalier, T.; Smith, F.P.; Harter, W.K.; Schein,
P.S.: Chemotherapy and combined modality therapy for
locally advanced and metastatic gastric carcinoma.
Seminars in Oncology 12:46-53, 1985.
Harvey, J.; Bonnem, E.; Grady, K.; Goodman, A.; Schein,
P.S.: A phase II study of daunorubicin in previously
untreated patients with advanced colorectal carcinoma.
Medical Pediatric Oncology, 13:30-31, 1985.
Ahlgren, J.; Schein, P.: Neoplasms of the hepatobiliary
system. Medical Oncology: Basic Principles and Clinical
Management of Cancer. Eds. Calabresi, P.; Schein,
P.; Rosenberg, S.: Macmillan, 851-874, 1985.
Schein, P.; Levin, B.: Neoplasms of the colon. Medical
Oncology: Basic Principles and Clinical Management
of Cancer. Eds. Calabresi, P.; Schein, P.; Rosenberg,
S.: Macmillan, 884-916, 1985.
Woolley, P.V.; Ayoob, M.J.; Smith, F.P.; Lokey, J.L.;
Degreen, P.; Marantz, A.; Schein, P.S.: A controlled
trial of the effect of 4?hydroxypyrazolopyrimidine
(allopurinol) on the toxicity of a single bolus dose
of 5-fluorouracil. Journal of Clinical Oncology 3:103-109,
1985.
Schein, P.S.: Clinical trials in gastric and colorectal
carcinoma. Clinical Trials in Cancer Medicine; Academic
Press, Inc. 439-460, 1985.
Nagourney, R.; Hedaya, R.; Linnoila, M.; Schein,
P.S.: Carcinoid carcinomatous meningitis. Annals of
Internal Medicine 102:779-782, 1985.
Litka, P.A.; Schein, P.S.: Chemotherapy of pancreatic
cancer. The Exocrine Pancreas: Biology, Pathobiology
and Diseases. Eds. V.L.W. Go; et al.: New York; Raven
Press, 689-697, 1984.
Schein, P.S.: Management of hepatic metastasis: A
general overview. Liver Metastasis: basic aspects,
detection and management. Martinus Nijhoff, 169-177,
1984.
Harvey J.H.; Schein P.S.: Chemotherapy of Pancreatic
Carcinoma. World Journal of Surgery 8:935-939, 1984.
Earl, H.M.; Coombes, R.C.; Schein, P.S.: Cytotoxic
chemotherapy for cancer of the stomach. Clinics in
Oncology, 3:351-369, 1984.
Woolley, P.V.; Ahlgren, J.D.; Byrne, P.J.; Priego,
V.M.; Schein, P.S.: A phase I trial of spirogermanium
administered on a continuous infusion schedule. Investigational
New Drug 2:305-309, 1984.
Harvey, J.; Schein, P.S.: Endocrine tumors. Cancer
Chemotherapy. Elsevier, Amsterdam 6:339-343, 1984.
Silgals, R.M.; Ahlgren, J.D.; Neefe, J.R.; Rothman,
J.; Rudnick, S.; Galicky, F.P.; Schein, P.S.: A Phase
II trial of high-dose intravenous interferon alpha-2
in advanced colorectal cancer. Cancer 54:2257-2261,
1984.
Schein, P.: Presidential Address: The plight of clinical
cancer research. Journal of Clinical Oncology 12:1433-1439,
1984.
Harvey, J.H.; Smith, F.P.; Bowers, M.W.; Neefe, J.R.;
Butler, T.P.; Gullo, J.J.; Schertz, G.; Lokey, J.;
Schein, P.S.; Woolley, P.V.: Phase II trial of PCNU
in advanced renal cell carcinoma and malignant melanoma.
Cancer Treatment Reports 68:1049-1050, 1984.
Schein, P.; Tew, K.: Nitrosoureas. Handbook of Experimental
Pharmacology, 72:425-442, 1984.
Harvey, J.; Goodman, A.; McFadden, M.; Schein, P.;
Smith, F.: A phase I study of daunorubicin in advanced
untreatable malignancies. Seminars in Oncology 11:33-35,
1984.
Rahman, A.; Fumagalli, A.; Goodman, A.; Schein, P.:
Potential of liposomes to ameliorate anthracycline-induced
cardiotoxicity. Seminars in Oncology 11:45-55, 1984.
Rahman, A.; Goodman, A.; Foo, W.; Harvey, J.; Smith,
F.; Schein, P.: Clinical pharmacology of daunorubicin
in phase I patients with solid tumors: Development
of an analytical methodology for daunorubicin and
its metabolites. Seminars in Oncology 11:36-44, 1984.
Mitchell, E.; Schein, P.: Gastrointestinal Toxicity
of Chemotherapeutic Agents. Toxicity of Chemotherapy,
269-296, 1984.
Wolkoff, A.W.; Stockert, R.J.; Schein, P.S.: Receptor-mediated
endocytosis by normal and proliferating hepatocytes
and liposomal drug delivery. Liver Metastasis: basic
aspects, detection and management, Martinus Nijhoff,
Boston, 278-291, 1984.
Smith, F.; Ellenberg, S.; Mayer, R.; Lessner, H.;
Horton, J.; Ruckdeschel, J.; Schein, P.S.: Phase II
study of methyl-CCNU, vincristine, 5-fluorouracil
and streptozotocin in advanced colorectal cancer.
Journal of Clinical Oncology 2:770-773, 1984.
Harris, M.A.; Byrne, P.J.; Smith, F.P.; Ueno, W.;
Schlesinger, C.; Oishi, S., Schein, P.S.: Treatment
of advanced breast cancer with two doxorubican-containing
regimens. American Journal of Clinical Oncology, 7:51-58,
1984.
Schein, P.S.; Smith, F.P.; Woolley, P.: Adjuvant
therapy of colon cancer - results of a prospectively
randomized trial. New England Journal of Medicine
310:737-743, 1984.
Harvey, J.; Smith, F.P.; Schein, P.S.: 5-Fluorouracil,
mitomycin, and doxorubicin (FAM) in carcinoma of the
biliary tract. Journal of Clinical Oncology 2:1245-1248,
1984.
Espana, P.; Smith, F.; Abrams, J.; Haidak, D.; Ueno,
W.; Woolley, P.V.; Schein, P.S.: Phase II study of
cis?diamine?dichcloroplatinum (cis-platinum), bleomycin
and methotrexate for advanced squamous cell carcinoma
of head and neck. Cancer Chemotherapy Pharmacology
12:98-100, 1984.
Schein, P.S.; Tew K.D.: Antineoplastic agents: Pharmacology
of nitrosourea anticancer agents. Clinical Chemotherapy.
Eds. H.P. Kuemmerle, K. Karrer, G. Mathe and P. Periti.
Antineoplastic Chemotherapy 264-274, 1984.
Schein, P.S.: How much toxicity is necessary? (Editorial)
Western Journal of Medicine 2:276-277, 1984.
Rahman, A.; Luc, P.V.T.; Schein, P.S.; Woolley, P.V.:
Pharmacological disposition of 1-(2-chloroethyl)-3?(2,6-dioxo-3-piperidyl)-1-nitrosourea
in mice. Cancer Research 44:149-153, 1984.
Korec, S.; Smith, F.P.; Schein, P.S.; Phillips, T.M.:
Clinical experiences with extra-corporeal immunoperfusion
of plasma from cancer patients. Journal of Biological
Response Modifiers, 3:330-335, 1984.
Byrne, P.; Tew, K.; Jemionek, J.; MacVittie, T.;
Erickson, L.; Schein, P.S.: Cellular and molecular
mechanisms of the bone marrow sparing effects of the
glucose chloroethylnitrosourea chlorozotocin. Blood
63:759-767, 1984.
Tormey, D.C.; Weinberg, V.E.; Holland, J.F.; Weiss,
R.B.; Glidewell, O.J.; Perloff, M.; Falkson, G.; Falkson,
H.C.; Henry, P.H.; Leone, L.A.; Rafla, S.; Ginsberg,
S.J.; Silver, R.T.; Blom, J.; Carey, R.W.; Schein,
P.S.; Lesnick, G.J.: A randomized trial of five and
three drug chemotherapy and chemoimmunotherapy in
women with operable node positive breast cancer. Journal
of Clinical Oncology 1:138-145, 1983.
Tew, K.D.; Erickson, L.C.; White, G.; Wang, A.L.;
Schein, P.S.; Hartley-Asp, B.: Cytotoxicity of estramustine,
a steroid?nitrogen mustard derivative, through non-DNA
targets. Molecular Pharmacology 24:324-328, 1983.
Goldin, A.G.; Schein, P.S.: Experimental models and
their predictive value in new drug development: A
critical appraisal: I. Toxicity Models. Cancer Chemotherapy
and Selective Drug Development, Martins Nighoff, Massachusetts,
209-214, 1983.
Herman, E.H.; Rahman, A.; Ferrans, V.J.; Vick, J.A.;
Schein, P.S.: Prevention of chronic doxorubicin cardiotoxicity
in beagles by liposomal encapsulation. Cancer Research
43:5427-5432, 1983.
Vu, V.T.; Tew, K.D.; Ahlgren, J.D.; Byrne, P.J.;
Wang, A.L.; Green, D.C.; Schein, P.S.: Chloroethylnitrosourea
interaction with chromatin: A potential mechanism
for bone marrow-sparing effect of the glucose analogs.
Cancer Treatment Symposia 1:37-43, 1983.
Smith, F.P.; Stablein, D.; Korsmeyer, S.; Neefe,
J.; Chun, B.K.; Woolley, P.V.; Schein, P.S.: Combination
chemotherapy for locally advanced pancreatic cancer:
Equivalence to external beam irradiation and implication
for future managment. Journal of Clinical Oncology
1:413-415, 1983.
Woolley, P.V.; Priego, V.M.; Luc, P.V.T.; Rahman,
A.; Schein, P.S.: Clinical pharmacokinetics of diammine
[1,1?cyclobutanedi carboxylato (2-)]-0, 0'-platinum
(CBDCA) 82-89, 1983.
Goffman, T.E.; McKeen, E.A.; Curtis, R.E.; Schein,
P.S.: Esophageal carcinoma following irradiation for
breast cancer. Cancer 52:1808-1809, 1983.
Gisselbrecht, C.; Smith, F.P.; Macdonald, J.S.; Korsmeyer,
S.J.; Boiron, M.; Woolley, P.V.; Schein, P.S.: The
effect of sequential addition of the nitrosourea,
chlorozotocin, to the FAM combination in advanced
gastric cancer. Cancer 51:1792-1794, 1983.
Goldin, A.; Woolley, P.V.; Tew, K.D.; Schein, P.S.:
Sources of agents and their selection for antitumor
activity screening. Methods and Findings in Experimental
and Clinical Pharmacology. Anticancer Drug Development,
9-25, 1983.
Goldin, A.; Rahman, A.; Casazza, A.M.; Guiliani,
F.; DiMarco, A.; Kaplan, N.O.; Schein, P.S.: The trigon
of host, tumor, and anthracycline in single drug and
combination therapy. Anthracyclines: Current status
and Future Developments. Eds. George Mathe, Rene Maral,
Robert DeJager, Masson, 65-71, 1983.
Tew, K.D.; Wang, A.L.; Schein, P.S.: Alkylating agent
interactions with the nuclear matrix. Biochemical
Pharmacology 32:3509-3516, 1983.
Rahman, A.; White, G.; More, M.; Schein, P.S.: Pharmacological,
toxicological, and therapeutic evaluation in mice
of doxorubicin entrapped in cardiolipin liposomes.
Cancer Research 45:796-801, 1985.
Mitchell. E.; Schein, P.S.: Complications of cytotoxic
and immunosuppressive chemotherapy. Clinical Management
of Poisoning and Drug Overdose 55:618-637, 1983.
Wang, A.L.; Schein, P.S.; Tew, K.D.: Importance
of phospholipids to nitrosourea interactions with
the nuclear envelope and associated nucleic acids.
Oncology 40:367-371, 1983.
Schein, P.S.; Tew, K.D.; Mathe, G.: Pharmacology
of nitrosourea anticancer agents. Clinical Chemotherapy
III, 66:264-274, 1982.
Schein, P.S.; Smith, F.P.; Woolley, P.V.; Ahlgren,
J.D.: Current management of advanced and locally unresectable
gastric carcinoma. Cancer 50:2590-2596, 1982.
Schein, P.S.: Breast cancer: Your role in detecting
it - Your role in treating it. Modern Medicine 71-83,
1982.
Schein, P.S.; Winokur, S.; Macdonald, J.S.; Woolley,
P.V.: Long-term complications of cytotoxic and immunosuppressive
chemotherapy. Cancer Medicine. Eds. E. Frei and J.
Holland, Lea and Febiger, 759-774, 1982.
Green, D.; Tew K.D.; Hisamatsu, T.; Schein, P.S.:
Correlation of nitrosourea murine bone marrow toxicity
with deoxyribonucleic acid alkylation and chromatin
binding sites. Biochemical Pharmacology 31:1671-1679,
1982.
Schein, P.S.; Stablein, D.M.; Bruckner, H.W.; Douglass,
H.; Mayer, R.; Ramming, K.; Bateman, J.; Livstone,
E.; et al: A comparison of combination chemotherapy
and combined modality therapy for locally advanced
gastric carcinoma. Cancer 49:1771-1777, 1982.
Rahman, A.; More, N.; Schein, P.S.: Doxorubicin-induced
chronic cardiotoxcity and its protection by liposomal
administration. Cancer Research 42:1817-1825, 1982.
Schein, P.S.; Gore, M.E.; Buckman, R.A.: Radiation
therapy and 5-fluorouracil. Drugs Experimental and
Clinical Research, VIII:587-592, 1982.
Zimmerman, S.E.; Smith, F.P.; Phillips, T.M.; Coffey,
R.J.; Schein, P.S.: Gastric carcinoma and thrombotic
thrombocytopenic purpura: Association with plasma
immune complex concentrations. British Medical Journal
284:1432-1434, 1982.
Jemionek, J.F.; MacVittie, T.J.; Byrne, P.J.; Schein,
P.S.; Walden, D.A.: Fractionation of mammalian bone
marrow by counterflow centrifugation-elutriation using
a continous albumin gradient: Analysis of granulocyte-macrophage
colony-forming units. British Journal of Haematology
50:257-266, 1982.
Ahlgren, J.D.; Green, D.C.; Tew, K.D.; Schein, P.S.:
Repair of DNA alkylation induced in L1210 leukemia
and murine bone marrow by three chloroethylnitrosourea.
Cancer Research 42:2605-2608, 1982.
Goffman, T.E.; Schechter, G.P.; McKeen, E.A.; Mariani-Costantini,
R.; Schein, P.S.: Renal cell carcinoma causing a selective
mineralocorticoid insufficiency. The Journal of Urology
128:370-371, 1982.
Tew, K.D.; Wang, A.L.; Lindner, D.J.; Schein, P.S.:
Enhancement of nitrosourea cytotoxicity in vitro using
hydrocortisone. Biochemical Pharmacology 31:1179-1180,
1982.
Smith, F.P.; Rustgi, V.K.; Schertz, G.; Woolley,
P.V.; Schein, P.S.: Phase II study of 5-FU, doxorubicin,
and mitomycin (FAM) and chlorozotocin in advanced
measurable pancreatic cancer. Cancer Treatment Reports,
66:2095-2096, 1982.
Cantrell, J.E.; Brunet, R.; Lagarde, C.; Schein,
P.S.; Smith, F.P.: Phase II study of sequential methotrexate-5-FU
therapy in advanced measurable colorectal cancer.
Cancer Treatment Reports 66:1563-1565, 1982.
Budman, D.R.; Ginsberg, S.; Perry, M.; Weinberg,
V.; Schein, P.S.; Hanson, J.; Colemen, M.; Wood, W.:
Phase II trial of spirogermanium in breast adenocarcinoma:
A cancer and leukemia group B study. Cancer Treatment
Reports 66:1667-1668, 1982.
Steele, G.; Ellenberg, S.; Ramming, K.; O'Connell,
M.; Moertel, C.; Lessner, H.; Bruckner, H.; Horton,
J.; Schein, P.S.; Zamcheck, N.; Novak, J.; Holyoke,
E.D.: CEA monitoring among patients in multi-institutional
adjuvant G.I. therapy protocols. Annals of Surgery
196:162-169, 1982.
Bonnem, E.M.; Mitchell, E.P.; Woolley, P.V.; Smith,
F.P.; Neefe, J.; Smith, L.; Schein, P.S.: Phase II
trial of mitoxantrone in advanced colorectal cancer.
Cancer Treatment Reports 66:1995-1996, 1982.
Hellman, K.; Herman, E.H.; Carter, S.K.; Eltringham,
J.; Schein, P.S.; et al.: Interaction of radiotherapy
and drugs. Current Chemotherapy and Immunotherapy,
1247-1251, 1982.
White, R.M.; Schein, P.S.: Colorectal carcinoma:
Adjuvant therapy. Current Therapy in Gastroenterology
and Liver Disease, 341-344, 1982.
Ardalan, B.; Macdonald, J.; Cooney, D.; Lippman,
M.; Schein, P.S.: The potential for clinical application
of in vitro assays predicting 5-FU sensitivity in
man. Cancer Treatment Reports 65:57-61, 1981.
Neefe, J.R.; Schein, P.S.: Chemotherapy of pancreatic,
colorectal and gastric cancer. Gastrointestinal Cancer.
Eds. J.J. DeCosse and P. Sherlock, 413-444, 1981.
Green, D.; Ahlgren, J.D.; Schein, P.S.: A molecular
basis for differences in nitrosourea bone marrow toxicity.
Nitrosoureas in Cancer Treatment. Eds. B. Serrou,
P. Schein and J.L., Imbac, Elsevier, Amsterdam, 49-59,
1981.
Goldin, A.; Schein, P.S.: Preclinical studies with
mitomycin-C and derivatives. Excerpta Medica, Proceedings
of a Symposium on Mitomycin?C presented during the
Third NCI-EORTC Symposium on New Drugs in Cancer Therapy,
Brussels, Belguim, 1-17, 1981.
Woolley, P.V.; Schein, P.S.; Marsoni, S.; Goldin,
A.G.: The rationale of anticancer drug selection for
clinical trials. Anticancer Drug Development 113-118,
1981.
Tew, K.D.; Schein, P.S.: Nitrosoureas. Antitumor
Drug Resistance. Handbook of Experimental Pharmacology.
Ed. B.W. Fox, Springer-Verlag, Berlin. 72:425-439.
Wang, A.L.; Tew, K.D.; Byrne, P.J.; Schein, P.S.:
Biochemical and pharmacologic properties of nitrosoureas.
Cancer Treatment Reports 65:119-124, 1981.
Kressel, B.R.; Ryan, K.P.; Duong, A.T.; Berenberg,
J.; Schein, P.S.: Microangiopathic hemolytic anemia,
thrombocytopenia and renal failure in patients treated
for adenocarcinoma. Cancer 48:1738-1745, 1981.
Smith, F.P.; Byrne, P.J.; Woolley, P.V.; Schein,
P.S.: Chemotherapy for gastric and esophageal cancer.
Gastrointestinal Cancer. Eds. J. Stroehlein and M.
Romsdah, Raven Press, N.Y., 189-197, 1981.
Byrne, P.J.; Schein, P.S.: Streptozotocin. Nitrosoureas
by Academic Press. 367-377, 1981.
Neefe, J.R.; Schein, P.S.: The management of disseminated
large-bowel cancer. Principles of Cancer Treatment.
McGraw-Hill, 402-407, 1981.
Hammer, C.F.; Loranger, R.A.; Schein P.S.: Structures
of the decomposition products of chlorozotocin: New
intramolecular carbamates of 2-amino-2-deoxyhexoses.
Journal of Organic Chemistry 46:1521-1531, 1981.
Rozencweig, M.; Von Hoff, D.D.; Staquet, M.J.; Schein,
P.S.; Penta, J.S.; Goldin, A.; Muggia F.M; Freireich,
E.J.; DeVita, V.T.: Animal toxicology for early clinical
trials with anticancer agents. Cancer Clinical Trials
4:21-28, 1981.
Woolley, P.V.; Luc, P.V.T.; Rahman, A.; Korsmeyer,
S.J.; Smith, F.P.; Schein, P.S.: Phase I trial and
clinical pharmacology of 1?(2chloroethyl)-3-(2, 6?dioxo?3?piperidyl)?1?nitrosourea
(PCNU). Cancer Research 41:3896-3900, 1981.
Goldenberg, D.M.; Neville, A.M.; Carter, A.C.; Go,
V.L.W.; Holyoke E.D.; Isselbacher, K.J.; Schein, P.S.;
Schwartz, M.: Carcinoembryonic antingen: Its role
as a marker in the management of cancer. British Medical
Journal 282:373-375, 1981.
Schein, P.S.; Smith, F.P.; Woolley, P.V.; Neefe,
J.R.; Byrne, P.J.: Cancers of the stomach, pancreas
and large bowel. Cancer: Achievements, challenges
and prospects for the 1980s. Grune and Stratton, 513-537,
1981.
Ahlgren, J.D.; Smith, F.P.; Kerwin, D.W.; Sikic,
B.I.; Weiner, J.H.; Schein, P.S.: Pulmonary disease
as a complication of chlorozotocin chemotherapy. Cancer
Treatment Reports 65:223-229, 1981.
Ardalan, B.; Macdonald, J.; Cooney, D.; Lippman,
M.; Schein, P.S.: Prediction of clinical response
to 5-fluorouracil containing chemotherapy: Preliminary
results of in vitro assay in human breast cancer.
Recent Results in Cancer Research 74:84-90, 1981.
Mittlelman, A.; Holyoke, E.; Thomas, P.R.M.; Moertel,
C.G.; Childs, D.S.; Weiland, L.; Horton, J.; Baxter,
D.; Eckert, C.; Levin, B.; Kinzie, J.; Schein, P.S.;
Smith, F.; Dritschilo, A., et al: Adjuvant chemotherapy
and radiotherapy following rectal surgery: An interim
report from the gastrointestinal tumor study group
(GITSG). Adjuvant Therapy of Cancer/III, Grune and
Stratton, Inc., 547-558, 1981.
Schein, P.S.: Cytotoxic chemotherapy of advanced
breast cancer. Systemic Control of Breast Cancer.
William Heinemann Ltd., 244-274, 1981.
Schein, P.S.; Macdonald, J.S.; Woolley, P.V.; Smith,
F.P.; Hoth, D.F.; Boiron, M.; Gisselbrecht, C.; Brunet,
R.; Lagrade, C.: The FAM regimen for gastric cancer:
A progress report. Recent Results in Cancer Research.
Eds. S.K. Carter, Y. Sakurai, H. Umezawa, 76:241-243,
1981.
Tew, K.D.; Smulson, M.E.; Schein, P.S.: Molecular
pharmacology of nitrosoureas. Recent Results in Cancer
Research. Eds. S.K. Carter, Y. Sakurai, H. Umezawa,
75:130-140, 1981.
Cambareri, R.J.; Smith, F.P.; Macdonald, J.S.; Haidak
D.J.; Ueno, W.M.; Hoth, D.H.; Woolley, P.V.; Schein,
P.S.: CAMP (cyclophosphamide, doxorubicin, methotrexate,
and procarbazine) for epidermoid and large cell anaplastic
carcinoma of the lung. Cancer Treatment Reports 65:317-320,
1981.
Killen, J.Y.; Holyoke, E.D.; Moertel, C.G.; Horton,
J.; Schein, P.S.; Bonadonna, G., et al.: Adjuvant
therapy of adenocarcinoma of the colon following clinically
curative resection: An interim report from the gastrointestinal
tumor study group (GITSG). Adjuvant Therapy of Cancer/III.
Grune and Stratton, Inc., 527-538, 1981.
Schein, P.S.: Clinical presentations of gastrointestinal
cancer. Cancer and Chemotherapy 2:113-124, 1981.
Zimmerman, S.E.; Smith, F.P.; Schein, P.S.: Chemotherapy
of pancreatic carcinoma. Cancer 47:1724-1728, 1981.
Mitchell, E.P.; Killen, J.Y.; Smith, F.P.; Willis,
L.L.; Schein, P.S.; Woolley, P.V.: Phase II study
of PCNU in colorectal carcinoma. Cancer Treatment
Reports 65:1129-1130, 1981.
Smith, F.P.; Schein, P.S.; Macdonald, J.S.; Woolley,
P.V.; Ornitz, R.; Rogers, C.: Fast neutron irradiation
for locally advanced pancreatic cancer. International
Journal of Radiation Oncology, Biology and Physics
7:1527-1531, 1981.
Schein, P.S.; Coffey, R.; Smith, F.P.: Chemotherapy
and combined modality treatment of gastric cancer.
Gastric Cancer, Pergammon Press, London, 139-148,
1981.
Schein, P.S.; Coffey, R.; Smith, F.P.: Future prospects
for gastric cancer. Gastric Cancer. Pergammon Press,
London, 231-233, 1981.
Schein, P.S.: Nitrosourea Antitumor Agents. Advances
in Cancer Chemotherapy, H. Umezawa et al., editors,
Japan Sci. Soc. Press, 95-106, 1981.
Kisner, D.L.; Schein, P.S.; Macdonald, J.S.: Recent
results of clinical therapeutic trials for gastrointestinal
malignancies conducted in the United States. Recent
Results in Cancer Research 79:28-40, 1981.
Goldenberg, D.M.; Neville, A.M.; Carter, A.C.; Go,
V.L.W.; Holyoke, E.D.; Isselbacher, K.J.; Schein,
P.S.; Schwartz, M.: CEA (Carcinoembryonic Antigen):
Its role as a marker in the management of cancer.
Journal of Cancer Research and Clinical Oncology 101:239-242,
1981.
Goffman, T.; Cantrell, J.; Schein, P.S.: Unexplained
increase in serum creatine kinase isoenzyme MB activity
in a lung cancer patient. Clinical Chemistry 27:2068-2069,
1981.
Pavlovsky, S.; Woolley, P.V.; Garay, G.; Scaglione
C.; Hoth, D.; Schein, P.S.: Phase II study of chlorozotocin
in leukemia and other hematologic malignancies. Cancer
Treatment Reports, 65:1109-1111, 1981.
Ahlgren, J.D.; Schein, P.S.: Chemotherapy and immunotherapy
of gastrointestinal cancer. Practical Gastroenterology,
Gastrointestinal Cancer - Part III, 5:18-22, 1981.
Mitchell, E.; Schein, P.S.: Gastrointestinal toxicity
of chemotherapeutic agents. Seminars in Oncology 9:52-64,
1982.
Gullo, J.J.; Citron, M.; Smith, F.P.; Macdonald,
J.S.; Schein, P.S.: Management of gastric and pancreatic
cancer. Cancer Treatment Research. Eds. J. Aisner
and P. Chang, Martinus Nijhoff, 119-141, 1980.
Killen, J.Y.; Schein, P.S.: The malignant lymphomas:
Current concepts of diagnosis and management. Journal
of Dermatological Surgery and Oncology, 6:378-382,
1980.
Magrath, I.; Lee, Y.J.; Anderson, T.; Henle, W.;
Ziegler, J.; Simon, R.; Schein, P.S.: Prognostic factors
in Burkitt's lymphoma: Importance of total tumor burden.
Cancer 45:1507-1515, 1980.
Morimoto, M.; Green, D.; Rahman, A.; Goldin, A.;
Schein, P.S.: Comparative pharmacology of pentamethylmelamine
and hexamethylmelamine in mice. Cancer Research 40:2762-2767,
1980.
Smith, F.P.; Byrne, P.J.; Cambareri, R.C.; Schein,
P.S.: Gastrointestinal cancer. Cancer Chemotherapy
Annual. Ed. J.M. Pinedo, Excerpta Medica, 2:292-316,
1980.
Smith, F.P.; Schein, P.S.: Progres therapeutiques
en cancerologie digestive. VII - Traitement Des Cancer
Du Pancreas. Medical Chir. Digest 9:341-347, 1980.
Smith, F.P.; Hoth, D.F.; Levin, B.; Karlin, D.A.;
Macdonald, J.S.; Woolley, P.V.; Schein, P.S.: 5-fluorouracil,
Adriamycin and mitomycin-C (FAM) chemotherapy for
advanced adenocarcinoma of the pancreas. Cancer 46:2014-2018,
1980.
Winchester, J.F.; Rahman, A.; Bregman, H.; Mortensen,
L.M.; Gelfand M.C.; Schein, P.S.; Schreiner, G.E.:
Role of hemoperfusion in anticancer drug removal.
Proceedings of International Symposium on Hemoperfusion,
Kidney, Liver Support and Detoxification, Haifa, Israel,
Part 1, 369-377, 1980.
Winchester, J.F.; Rahman, A.; Tilstone, W.J.; Bregman,
H.; Mortensen, L.M.; Gelfand, M.C.; Schein, P.S.;
Schreiner, G.E.: Will hemoperfusion be useful for
cancer chemotherapeutic drug removal? Clinical Toxicology
17(4):557-569, 1980.
Schein, P.S.; Slavik, M.; Smythe, T.; Hoth, D.; Smith,
F.; Macdonald, J.S.; Woolley, P.V.: Phase I clinical
trial of spirogermanium. Cancer Treatment Reports
64:1051-1056, 1980.
Franza, B.R.; Oeschger, N.S.; Oeschger, M.P.; Schein,
P.S.: Mutagenic activity of nitrosourea antitumor
agents. Journal of the National Cancer Institute 65:149-154,
1980.
Macdonald, J.S.; Woolley, P.V.; Schein, P.S.: Clinical
strategies in the chemotherapy of gastrointestinal
cancer. Recent Results in Cancer Research 70:179-185,
1980.
Macdonald, J.S.; Hoth, D.; Schein, P.S.: Preclinical
and clinical studies on chlorozotocin, a new nitrosourea
with decreased bone marrow toxicity. Recent Results
in Cancer Research 70:83-89, 1980.
Kuhn, J.A.; Argy, W.P.; Rakowski, T.A.; Moriarty,
J.K.; Schreiner, G.E.; Schein, P.S.: Nephrotoxicity
of cis-diamminedichloroplatinum (II) as measured by
urinary beta-glucuronidase, Cancer Treatment Reports
64:1083-1086, 1980.
Tew, K.D.; Schein, P.S.; Lindner, D.J.; Wang, A.L.;
Smulson, M.E.: Influence of hydrocortisone on the
binding of nitrosoureas to nuclear chromatin subfractions.
Cancer Research 40:3697-3703, 1980.
Rahman, A.; Kessler, A.; More, N.; Sikic, B.; Rowden,
G.; Woolley, P.; Schein, P.S.: Liposomal protection
of Adriamycin?induced cardio-toxicity in mice. Cancer
Research 40:1532-1537, 1980.
Ardalan, B.; Cooney, D.A.; Jayaram, H.N.; Carrico,
C.K.; Glazer, R.I.; Macdonald, J.; Schein, P.S.: Mechanisms
of sensitivity and resistance of murine tumors to
5-fluorouracil. Cancer Research 40:1431-1437, 1980.
Smith, F.P.; Kisner, D.; Schein, P.S.: Nutrition
and Cancer: Prospects for clinical research. Nutrition
and Cancer 2:34-39, 1980.
Kisner, D.L.; Schein, P.S.; Macdonald, J.S.: Recent
results of clinical therapeutic trails for gastrointestinal
malignancies conducted in the United States. International
Congress of Gastroenterology, 1980.
Tew, K.D.; Smulson, M.E.; Schein, P.S.: Perspectives
on the mode of action of nitrosourea anticancer agents.
Excerpta Medica 5:332-341, 1980.
Macdonald J.S.; Schein, P.S.; Woolley, P.V.; Smythe,
T.; Ueno, W.; Hoth, D.; Smith, F.; Boiron, M.; Gisselbrecht,
C.; Brunet, R.; Lagarde, C.: 5-Fluorouracil, doxorubicin
and mitomycin (FAM) combination chemotherapy for advanced
gastric cancer. Annals of Internal Medicine 93:533-536,
1980.
Smith, F.P.; Macdonald J.S.; Schein, P.S.; Ornitz,
R.: Cutaneous seeding of pancreatic cancer by skinny-needle
aspiration biopsy. Archives of Internal Medicine 140:855,
1980.
Hoth, D.F.; Schein, P.S.; Winokur, S.; Woolley, P.V.;
Robichaud, K.; Binder, R.B.; Smith, F.P.: A Phase
II study of chlorozotocin in metastatic malignant
melanoma. Cancer 46:1544-1547, 1980.
Schein, P.S.; Macdonald, J.S.; Hoth, D.F.; Woolley,
P.V.: The FAM (5?fluorouracil, adriamycin, mitomycin-C)
and SMF (strepto-zotocin, mitomycin C, 5-fluorouracil)
chemotherapy regimens. Mitomycin-C Current Status
and New Development. Eds. S.K. Carter; S.T. Crooke:
Academic Press, Inc., 133-143, 1979.
Schein, P.S.; Macdonald, J.S.; Hoth, D.F.; Woolley,
P.V.: The FAM (5-fluorouracil, Adriamycin, mitomycin
C) and SMF (streptozotocin, mitomycin C, 5-fluorouracil)
chemotherapy regimens. Mitomycin C: current status
and new developments, Academic Press, 133-142, 1979.
Ardalan, B.; Macdonald, J.S.; Cooney, D.; Schein,
P.S.: Studies on mechanisms of 5-fluorouracil resistance
in murine and human tumors. Bulletin du Cancer 66:55-59,
1979.
Winchester, J.F.; Rahman, A.; Tilstone, W.J.; Kessler,
A.; Mortensen, L.; Schreiner, G.E.; Schein, P.S.:
Sorbent removal of Adriamycin in vitro and in vivo.
Cancer Treatment Reports 63:1787-1793, 1979.
Woolley, P.V.; Schein, P.S.: Clinical pharmacology
and phase I trial design. Methods in Cancer Research
17: 177-198, 1979.
Heal, J.M.; Fox, P.; Schein, P.S.: A structure-activity
study of seven new water soluble nitrosoureas. Biochemical
Pharmacology 28:1301-1306, 1979.
Sudhakar, S.; Tew, K.D.; Schein, P.S.; Woolley, P.V.;
Smulson, M.E.: Nitrosourea interaction with chromatin
and effect on poly (adenosine diphosphate ribose)
polymerase activity. Cancer Research 39:1411-1417,
1979.
Heal, J.M.; Fox, P.A.; Schein, P.S.: Effect of carbamoylation
on the repair of nitrosourea-induced DNA alkylation
damage in L1210 cells. Cancer Research 39:82-89, 1979.
Panasci, L.C.; Green, D.; Schein, P.S.: Chlorozotocin:
Mechanism of reduced bone marrow toxicity in mice.
Journal of Clinical Investigation 64:1103-1111, 1979.
Tew, K.D.; Pinsky, S.D.; Schein, P.S.; Smulson, M.E.;
Woolley, P.V.: Molecular aspects of nitrosamide carcinogenicity.
Excerpta Medica 5:387-395, 1980.
Schein, P.S.; Kisner, D.; Haller, D.; Blecher, M.;
Hamosh, M.: Cachexia of malignancy: Potential role
of insulin in nutritional management. Cancer 43:2070-2076,
1979.
Butler, T.P.; Macdonald, J.S.; Smith, F.P.; Smith,
L.F.; Woolley, P.V.; Schein, P.S.: 5-Fluorourcil,
Adriamycin, and mitomycin-C (FAM) chemotherapy for
adenocarcinoma of the lung. Cancer 43:1183-1188, 1979.
Schein, P.S.: Tumor markers. Textbook in Medicine.
Eds. P. Beeson, W. McDermott, and J. Wyngaarden. Edition
Fifteen, 1911-1914, 1979.
Schein, P.S.: Medical oncology: Cancer biology, endocrine
tumors, lung cancer, and gastrointestinal cancer.
In: The American College of Physicians - Medical Knowledge
Self-Assessment Program V (MKSAP-V), 93:123, 1979.
Woolley, P.V.; Macdonald, J.S.; Smythe, T.; Haller,
D.G.; Hoth, D.F.; Rosenoff, S.; Schein, P.S.: A phase
II trial of ftorafur: Adriamycin and mitomycin-C (FAM
II) in advanced gastric adenocarcinoma. Cancer 44:1211-1214,
1979.
Wiggans, R.G.; Woolley, P.V.; Smythe, T.; Hoth, D.;
Macdonald, J.S.; Green, L.; Schein, P.S.: Phase II
trial of tamoxifen in advanced breast cancer. Cancer
Chemotherapy Pharmacology 3:45-48, 1979.
Macdonald, J.S.; Woolley, P.V.; Smythe, T.; Ueno,
W.; Hoth, D.; Schein, P.S.: 5-Fluorouracil, Adriamycin,
and mitomycin-C (FAM) combination chemotherapy in
the treatment of advanced gastric cancer. Cancer 44:42-47,
1979.
Smith, F.P.; Schein, P.S.: Chemotherapy of pancreatic
cancer. Seminars in Oncology, 6:368-377, 1979.
Schein, P.S.; Smith, F.; Woolley, P.V.; Hoth, D.F.;
Macdonald, J.S.: Chemotherapy of pancreatic cancer.
Advances in Medical Oncology, Research and Education,
Digestive Cancer. Ed. N. Thatcher, Pergammon Press,
Oxford and New York, 9:187-190, 1979.
Goldin, A.; Rozencweig, M.; Guarino, A.M.; Schein,
P.S.: Chapter II: Quantitative and qualitative prediction
of toxicity from animals to human. Controversies in
Cancer (Design of Trials and Treatment). Proc. EORTC
Symposium, Brussels, April 26-29, 1979. Eds. H. Tagnon
and M. Staquet, 83-104, 1979.
Woolley, P.V.; Higgins, G.A.; Schein, P.S.: Ongoing
trials in the surgical adjuvant management of colorectal
cancer. Recent Results in Cancer Research 68:231-235,
1979.
Macdonald, J.S.; Schein, P.S.: Endocrine tumors.
Guide To Therapeutic Oncology. Eds. P.R. Bergevin,
J. Blom, D. Tormey, 497-518, 1979.
Smith, F.P.; Bryne, P.J.; Cambareri, R.C.; Schein,
P.S.: Gastrointestinal cancer. Cancer Chemotherapy.
Excerpta Medica, Amsterdam-Oxford, 1:292-316, 1979.
Woolley, P.C.; Macdonald, J.S.; Hoth, D.F.; Smith,
F.P.; Schein, P.S.: Current management of the gastrointestinal
malignancies. Advancement in Medical Oncology, Research
and Education, Digestive Canver. Ed. N. Thatcher,
Pergammon Press Oxford and New York, 9:295-299, 1979.
Schwartz, J.H.; Schein, P.S.: Fanconi syndrome associated
with cephalothin and gentamicin therapy. Cancer 41:769-772,
1978.
Smith, F.P.; Butler, T.P.; Cohan, S.; Schein, P.S.:
Laetrile toxicity: A report of two patients. Cancer
Treatment Reports 62:169-171, 1978.
Ardalan, B.; Buscaglia, M.D.; Schein, P.S.: Tumor
5-fluorodeoxyuridylate concentration as a determinant
of 5-fluorouracil response. Biochemical Pharmacology
27:2009-2013, 1978.
Nagourney, R.A.; Fox, P.A.; Schein, P.S.: A comparison
of the biological and biochemical properties of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea
and 2-[3-(2-choroethyl)-3-nitrosoureido]-D-glucopyranose.
Cancer Research 38:65-68, 1978.
Schein, P.S.; Bull, J.M.; Doukas, D.; Hoth, D.: Sensitivity
of human and murine hematopoietic precursor cells
to 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose
and 1,3-bis(2-chlorethyl)-1-nitrosourea. Cancer Research
38:257-260, 1978.
Mhatre, R.M.; Green, D.; Panasci, L.C.; Fox, P.;
Woolley, P.V.; Schein, P.S.: Pharmacologic disposition
of chlorozotocin in mice. Cancer Treatment Reports
62:1145-1151, 1978.
Tew, K.D.; Sudhakar, S.; Schein, P.S.; Smulson, M.E.:
Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
to chromatin and nucleosomal fractions of HeLa cells.
Cancer Research 38:3371-3378, 1978.
Heal, J.M.; Fox, P.A.; Doukas, D.; Schein, P.S.:
Biological and biochemical properties of the 2-hydroxyl
metabolites of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
(CCNU). Cancer Research 38:1070-1074, 1978.
Hoth, D.; Woolley, P.; Green, D.; Macdonald, J.;
Schein, P.S.: Phase I studies on chlorozotocin. Clinical
Pharmacology and Therapeutics 23:712-722, 1978.
Wiggans, R.G.; Jacobson, R.J.; Fialkow, P.J.; Woolley,
P.V.; Macdonald, J.S.; Schein, P.S.: Probable clonal
origin of acute myeloblastic leukemia following radiation
and chemotherapy of colon cancer. Blood 52:659-663,
1978.
Wiggans, R.G.; Woolley, P.V.; Macdonald, J.S.; Smythe,
T.; Ueno, W.; Schein, P.S.: Phase II trial of streptozotocin,
mitomycin-C and 5-fluorouracil (SMF) in the treatment
of advanced pancreatic cancer. Cancer 41:387-391,
1978.
Bayly, T.C.; Kisner, D.L.; Sybert, A.; Macdonald,
J.S.; Tsou, E.; Schein, P.S.: Tetracycline and quinacrine
in the control of malignant pleural effusion: A randomized
trial. Cancer 41:1188-1192, 1978.
Schein, P.S.; Lavin, P.T.; Moertel, C.G., et al:
Randomized phase II clinical trial of Adriamycin,
methotrexate, and actinomycin-D in advanced measurable
pancreatic carcinoma. Cancer 42:19-22, 1978.
Haller, D.G.; Woolley, P.V; Macdonald, J.S.; Smith,
L.F.; Schein. P.S.: Phase II trial of 5-fluorouracil,
adriamycin and mitomycin C (FAM) in advanced colorectal
cancer. Cancer Treatment Reports 62:563-565, 1978.
Macdonald, J.S.; Lippman, M.E.; Woolley, P.V.; Petrucci,
P.P.; Schein, P.S.: Hepatic estrogen and progesterone
receptors in an estrogen-associated hepatic neoplasm.
Cancer Chemotherapy and Pharmacology 1:135-138, 1978.
Israel, L.; Edelstein, R.; Macdonald, J.; Weiss,
J.; Schein, P.S.: Immunological and plasma protein
changes in cancer patients following a single plasmapheresis.
Biomedicine 28:292-297, 1978.
Woolley, P.V.; Hoth, D.F.; Schein, P.S.: Pharmacology
of nitrosoureas. Revista Latinoamericana de Quimioterapia
Antineoplasica 10:21-29, 1978.
Heal, J.M.; Franza, B.R.; Schein, P.S.: Pharmacology
of nitrosourea antitumor agents. Elsevier/North-Holland
Biomedical Press. 263-275, 1978.
Schein, P.S.: Nitrosourea antitumor agents. Advances
in Cancer Chemotherapy 95-106, 1978.
Woolley, P.V.; Macdonald, J.S.; Schein, P.S.: Current
treatment of advanced gastric cancer. Revista Latinoamericana
de Quimioterapia Antineoplasica 10:38-42, 1978.
Levin, B.; ReMine, W.H.; Hermann, R.E.; Schein, P.S.;
Cohn, I.: Panel: Cancer of the pancreas: Current approaches
to diagnosis of pancreatic cancer. American Journal
of Surgery 135:185-191, 1978.
Schein, P.S.; Hoth, D.F.: Therapy of colorectal carcinoma.
Immunotherapy of Cancer: Present status of trials
in man; Eds. W.D. Terry and D. Windhorst, Raven press,
N.Y., 563 -571, 1978.
Schein, P.S.; Heal, J.; Green. D.; Woolley, P.V.:
Pharmacology of nitrosourea anticancer agents. 10th
International Congress on Chemotherapy. Antibiotics
Chemotherapy. Eds. F.M. Schabel, Karger, Basel, 23:64-75,
1978.
Schein, P.S.: Current concepts in the drug treatment
of cancer. Medical Times 106:25-29, 1978.
Cohen, M.I.; Widerlite, L.W.; Schechter, G.P.; Jaffe,
E.; Fischmann, A.B.; Schein, P.S.; Macdonald, J.S.:
Gastrointestinal involvement in the Sezary syndrome.
Gastroenterology 73:145-149, 1977.
Heal, J.M.; Schein, P.S.: Management of Gastrointestinal
Cancer. Medical Clinics of North America, Philadelphia,
W.B. Saunders, 61:991-999, 1977.
Isner, J.; Macdonald, J.S.; Schein, P.S.: Spontaneous
streptococcal pneumonia peritonitis in a patient with
metastatic gastric cancer: A case report and etiologic
consideration. Cancer 39:2306-2309, 1977.
Macdonald, J.S.; Widerlite, L.; Schein, P.S.: Biology,
diagnosis, and chemotherapeutic management of pancreatic
malignancy. Advances in Pharmacology and Chemotherapy
14:107-140, 1977.
Panasci, L.C.; Fox, P.A.; Schein, P.S.: Structure-activity
studies of methylnitrosourea antitumor agents with
reduced murine bone marrow toxicity. Cancer Research
37:3321-3328, 1977.
Schein, P.S.: Preclinical toxicology of anticancer
agents. Cancer Research 37:1934-1937, 1977.
Woolley, P.V.;Macdonald, J.S.; Schein, P.S.: Chemotherapy
of malignancies of the gastrointestinal tract. Progress
in Gastroenterology 3:671-692, 1977.
Schein, P.S.: Preclinical toxicology for introduction
of a new anticancer agent into phase I clinical trial.
Chemioterapia Oncologica 1:10-15, 1977.
Smulson, M.E.; Schein, P.S.; Mullins, D.W.; Sudhakar,
S.: A putative role for nicotinamide adenine dinucleotide-promoted
nuclear protein modification in the antitumor activity
of N-methyl-N-nitrosourea. Cancer Research 37:3006-3012,
1977.
Fox, P.A.; Panasci, L.C.; Schein, P.S.: Biological
and biochemical properties of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea
(GANU) (NSC D 254157), a nitrosourea with reduced
bone marrow toxicity. Cancer Research 37:783-787,
1977.
Panasci, L.C.; Green, D.; Nagourney, R.; Fox, P.;
Schein, P.S.: A structure-activity analysis of chemical
and biological parameters of chloroethylnitrosoureas
in mice. Cancer Research 37:2615-2618, 1977.
Panasci, L.C.; Green, D.C.; Fox, P.A.; Schein, P.S.:
A phenol technique for extraction of alkylated DNA,
RNA, and protein from a single tissue sample. Analytical
Biochemistry 83:678-688, 1977.
Woolley, P.V.; Macdonald, J.S.; Schein, P.S.: Chemotherapy
of Malignancies of the Gastrointestinal Tract. Progess
in Gastroenterology 3:671-692, 1977.
Macdonald, J.S.; Kisner, D.F.; Smythe, T.A.; Woolley,
P.V.; Smith, L.; Schein, P.S.: 5-Fluorouracil (5-FU),
methyl-CCNU, and vincristine in the treatment of advanced
colorectal cancer: Phase II study utilizing weekly
5-FU. Cancer Treatment Reports 60:1597-1600, 1976.
Macdonald, J.S.; Widerlite, L.; Schein, P.S.: Current
diagnosis and management of pancreatic carcinoma.
Journal of the National Cancer Institute 56:1093-1099,
1976.
Macdonald, J.S.; Schein, P.S.: Mechanisms and management
of malnutrition states in patients with cancer. Clinics
in Gastroenterology, 5:809-826, 1976.
Wiggans, G.; Schein, P.S.; Macdonald, J.S.; Schellinger,
D.; Harbert, J.: Computerized axial tomography for
diagnosis of pancreatic cancer. Lancet 2:233-235,
1976.
Canellos, G.P.; DeVita, V.T.; Gold, G.L.; Chabner,
B.A.; Schein, P.S.; Young, R.C.: Cyclical combination
chemotherapy for advanced breast carcinoma: British
Medical Journal 218-220, 1974.
Morgan, L.R.; Schein, P.S.; Woolley, P.V.; Hoth,
D.; Macdonald, J.; Lippman, M.; Posey, L.E.; Beazley,
R.W.: Therapeutic use of Tamoxifen in advanced breast
cancer: Correlation with biochemical parameters. Cancer
Treatment Reports 60:1437-1443, 1976.
Bunn, P.A.; Schein, P.S.; Banks, P.M.; DeVita, V.T.:
Central nervous system complications in patients with
diffuse histiocytic and undifferentiated lymphoma:
Leukemia revisited. Blood 47:3-10, 1976.
Schein, P.S.; Macdonald, J.S.; Edelson, R.: Cutaneous
T-cell lymphoma. Cancer 38:1859-1861, 1976.
Schein, P.S.; DeVita, V.T.; Hubbard, S.; Chabner,
B.A.; Canellos, G.P.; Berard, C.; Young, R.C.: Bleomycin,
adriamycin, cyclophosphamide, vincristine, and prednisone
(BACOP) combination chemotherapy in the treatment
of advanced diffuse histiocytic lymphoma. Annals of
Internal Medicine 85:417-422, 1976.
Schein, P.S.; Panasci, L.; Woolley, P.V.; Anderson,
T.: Pharmacology of chlorozotocin (NSC-178248), a
new nitrosourea antitumor agent. Cancer Treatment
Reports 60:801-805, 1976.
Rakieten, N.; Gordon, B.S.; Beaty, A.; Cooney, D.A.;
Schein, P.S.: Modification of renal tumorigenic effect
of streptozotocin Diabetes (39209). Proceedings of
the Society for Experimental Biology and Medicine
151:356-361, 1976.
Rakieten, N.; Gordon, B.S.; Beaty, A.; Bates, W.;
Schein, P.S.: Streptozotocin treatment of streptozotocin-induced
islet cell adenomas in rats. Proceedings of the Society
for Experimental Biology and Medicine 151:632-635,
1976.
Schein, P.S.: Chemotherapy of gastrointestinal endocrine
tumors. Procedures of the Fifth International Congress
of Endocrinology 453-457, 1976.
Schein, P.S.; Anderson, T.; McMenamin, M.G.; Bull,
J.: Streptozotocin, chlorozotocin and related nitrosourea
antitumor agents. Chemotherapy 7:159-166, 1976.
Woolley, P.V.; Macdonald, J.S.; Schein, P.S.: Chemotherapy
of colorectal carcinoma. Seminars in Oncology 3:415-420,
1976.
Canellos, G.P.; DeVita, V.T.; Whang-Peng, J.; Chabner,
B.A.; Schein, P.S.; Young, R.C.: Chemotherapy of the
blastic phase of chronic granulocytic leukemia: Hypodiploidy
and response to therapy. Blood 47:1003-1009, 1976.
Pederson, R.T.; Haidak, D.J.; Ferris, R.A.; Macdonald,
J.S.; Schein, P.S.: Osteoblastic bone metastasis in
Zollinger-Ellison syndrome. Radiology 118:63-64, 1975.
Lutzner, M.; Edelson, R.L.; Schein, P.S.: Cutaneous
T-Cell lymphomas: Sezary syndrome. Current Dermatologic
Managment. Eds. S. Maddin, C. V. Mosby, S. Lois, 286:287,
1975.
Anderson, T.; McMenamin, M.G.; Schein, P.S.: Diabetogenic
activity of deoxy-2-[[(ethylnitrosoamino) carbonyl]
amino]- D-glucopyranose (DENU). Biochemical Pharmacology
24:746-747, 1975.
Kahn, C.R.; Levy, A.G.; Gardner, J.D.; Miller, J.V.;
Gorden, P.; Schein, P.S.: Pancreatic cholera: Beneficial
effects of treatment with streptozotocin. New England
Journal of Medicine 292:941-945, 1975.
Anderson, T.; McMenamin, M.G.; Schein, P.S.: Chlorozotocin,
2-[3-(2-Chloroethyl)-3-nitrosoureido]-D-glucopyranose,
an antitumor agent with modified bone marrow toxicity.
Cancer Research 35:761-765, 1975.
Schein, P.S.; Chabner, B.A.; Canellos, G.P.; Young,
R.C.; Berard, C.; DeVita, V.T.: Results of combination
chemotherapy of non-Hodgkin's lymphoma. British Journal
of Cancer 31:465-473, 1975.
Chabner, B.A.; Johnson, R.E.; Chretien, P.B.; Schein,
P.S.; Young, R.C.; Canellos, G.P.; Hubbard, S.H.;
Anderson, T.; Rosenoff, S.H.; DeVita, V.T.: Percutaneous
liver biopsy, peritoneoscopy and laparotomy: An assessment
of relative merits in the lymphomata. British Journal
of Cancer 31:242-247, 1975.
Canellos, G.P.; DeVita, V.T.; Young, R.C.; Chabner,
B.A.; Schein, P.S.; Johnson, R.E.: Therapy of advanced
lymphocytic lymphoma: A preliminary report of randomized
trial between combination chemotherapy (CVP) and intensive
radiotherapy. British Journal of Cancer 31:474-480,
1975.
DeVita, V.T.; Cancellos, G.P.; Chabner, B.A.; Schein,
P.S.; Hubbard, S.P.; Young, R.C.: Advanced diffuse
histiocytic lymphoma a potentially curable disease:
Results with combination chemotherapy. Lancet 1:248-252,
1975.
Rosenoff, S.H.; Young, R.C.; Anderson, T.; Bagley,
C.; Chabner, B.; Schein, P.S.; Hubbard S.; DeVita,
V.T.: Peritoneoscopy: A valuable staging tool in ovarian
carcinoma. Annals of Internal Medicine 83:37-41, 1975.
Rosenoff, S.H.; Young, R.C.; Chabner, B.; Hubbard
S.; DeVita, V.T.; Schein, P.S.: Use of peritoneoscopy
for initial staging and post-therapy evaluation of
patients with ovarian carcinoma. NCI Monograph 42:81-86,
1975.
Schein, P.S.; Kisner, D.; Macdonald, J.S.: Chemotherapy
of large intestinal carcinoma: Current results and
future prospects. Cancer 36:2418-2420, 1975.
Schein, P.S.; Macdonald, J.S.; Waters, C.; Haidak,
D.: Nutritional complications of cancer and its treatment.
Seminars in Oncology 2:337-347, 1975.
Schein, P.S.: The prediction of clinical toxicities
of anticancer drugs. Pharmacological Basis of Cancer
Chemotherapy, Williams and Wilkins, Baltimore, 383-395,
1975.
Schein, P.S.; Winokur, S.H.: Immunosuppressive and
cytotoxic chemotherapy: Long-term complications. Annals
of Internal Medicine 82:84-95, 1975.
Lutzner, M.; Edelson, R.; Schein, P.S.; Green, I.;
Kirkpatrick, C.; Ahmed, A.: Cutaneous T-cell lymphomas:
The Sezary syndrome, mycosis fungoides, and Related
Disorders, NIH Conference. Annals of Internal Medicine
83:534-552, 1975.
Brereton, H.D.; Anderson, T.; Johnson, R.E.; Schein,
P.S.: Hyperphosphatemia and hypocalcemia in Burkitt's
lymphoma: Complications of chemotherapy. Archives
of Internal Medicine 135:307-309, 1975.
Schein, P.S.; Chabner, B.A.; Canellos, G.P.; Young,
R.C.; DeVita, V.T.: Non-Hodgkin's lymphoma: Patterns
of relapse from complete remission after combination
chemotherapy. Cancer 35:354-357, 1975.
Anderson, T.; Schein, P.S.; McMenamin, M.G.; Cooney,
D.A.: Streptozotocin diabetes: Correlation with extent
of depression of pancreatic islet nicotinamide adenine
dinucleotide. Journal of Clinical Investigation 54:672-677,
1974.
Anderson, T.; Schein, P.S.; Jencks, J.A.; Binder,
R.A.: The nitroblue tetrazolium (NBT) dye test in
determining fever source in lymphoma. Cancer 34:705-710,
1974.
Edelson, R.L.; Kirkpatrick, C.H.; Shevach, E.M.;
Schein, P.S.; Smith, R.W.; Green, I.; Lutzner, M.:
Preferential cutaneous infiltration by neoplastic
thymus-derived lymphocytes: Morphologic and functional
studies. Annals of Internal Medicine 80:685-692, 1974.
Edelson, R.; Facktor, M.; Andrews, A.; Lutzner, M.;
Schein, P.S.: Successful management of the Sezary
Syndrome: Mobilization and removal of extravascular
neoplastic T-cells by leukapheresis. New England Journal
of Medicine 291:293-294, 1974.
Canellos, G.P.; DeVita, V.T.; Gold, G.L.; Chabner,
B.A.; Schein, P.S.; Young, R.C.: Cyclical combination
chemotherapy for advanced breast carcinoma. British
Medical Journal 1:218-220, 1974.
Schaeppi, U.; Menninger, F.; Fleischman, R.W.; Bodgen,
A.E.; Schein, P.S.; Cooney, D.A.: Toxicity of neocarzinostatin
(NSC-69856): An antitumor antibiotic with radiomimetic
and antigenic characteristics. Cancer Chemotherapy
Reports 5:43-52, 1974.
Schein, P.S.; O'Connell, M.J.; Blom, J.; Hubbard,
S.; Magrath, I.T.; Bergevin, P.; Wiernik, P.H.; Ziegler,
J.L.; DeVita, V.T.: Clinical antitumor activity and
toxicity of streptozotocin (NSC-85998). Cancer 34:993-1000,
1974.
Schein, P.S.; Chabner, B.A.; Canellos, G.P.; Young,
R.C.; Berard, C.; DeVita, V.T.: Potential for prolonged
disease-free survival following combination chemotherapy
of non-Hodgkin's lymphoma. Blood 43:181-189, 1974.
Young, R.C.; Canellos, G.P.; Chabner, B.A.; Schein,
P.S.; Hubbard, S.P.; DeVita, V.T.: Chemotherapy for
advanced ovarian carcinoma: A prospective randomized
comparison of phenylalanine mustard and high dose
cyclophosphamide. Gynecologic Oncology 2:489-497,
1974.
Bagley, C.M.; Young, R.C.; Schein, P.S.; Chabner,
B.A.; DeVita, V.T.: Ovarian carcinoma metastatic to
the diaphram--frequently undiagnosed at laparotomy.
American Journal Obstetrics & Gynecology 116:397-400,
1973.
Henry, M.C.; Davis, R.D.; Schein, P.S.: Hepatotoxicity
of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
in dogs: The use of serial percutaneous liver biopsies.
Toxicology and Applied Pharmacology 25:410-417, 1973.
Young, R.C.; Goldberg, D.; Schein, P.S.: Enhanced
antitumor effect of cytosine arabinoside given in
a schedule dictated by kinetic studies in vivo. Biochemical
Pharmacology 22:277-280, 1973.
Chabner, B.A.; Sponzo, R.; Hubbard, S.; Canellos,
G.P.; Young, R.C.; Schein, P.S.; DeVita, V.T.: High-dose
intermittent intravenous infusion of procarbazine.
Cancer Chemotherapy Reports 57:361-363, 1973.
Schein, P.S.; McMenamin, M.G.; Anderson, T.: 3-(Tetracetyl
glucopyranos-2-yl)-1-(2-chloroethyl)-1-nitrosourea,
GCNU (NSC-114460), an antitumor agent with modified
bone marrow toxicity. Cancer Research 33:2005-2009,
1973.
Young, R.C.; Cancellos, G.P.; Chabner, B.A.; Schein,
P.S.; Brereton, H.D.; DeVita, V.T.: Treatment of malignant
melanoma with methyl CCNU. Clinical Pharmacology and
Therapeutics 15:617-622, 1973.
Schein, P.S.: Chemotherapy in advanced ovarian cancer.
Geriatrics 28:89-95, 1973.
DeVita, V.T.; Schein, P.S.: The use of drugs in combination
for the treatment of cancer: Rationale and results.
New England Journal of Medicine 288:998-1006, 1973.
Schein, P.S.: Cancer chemotherapy: Current concepts
and results. Current Research in Oncology, Academic
Press, New York, 1972. Ed. C. Anfinsen, 167-208, 1973.
DeVita, V.T.; Canellos, G.P.; Schein, P.S.; Chabner,
B.A.; Bagley, C.M.; Young, R.C.: Malignant lymphoma:
Treatment with combination chemotherapy. Proceedings
from the 7th National Cancer Conference, J.B. Lippincott,
Philadelphia, 379-392, 1973.
Schein, P.S.; Davis, R.D.; Cooney, D.A.: Qualitative
aspects of drug toxicity in prediction from laboratory
animals to man. Proceedings of the 5th International
Congress on Pharmacology 3:304-335, 1973.
Schein, P.S.; Anderson, T.: The efficacy of animal
studies in predicting clinical toxicity of cancer
chemotherapeutic drugs. International Journal of Clinical
Pharmacology 8:228-238, 1973.
Canellos, G.P.; DeVita, V.T.; Schein, P.S.; Chabner,
B.A.; Young, R.C.: The chronic leukemias: Current
therapeutic concepts. Proceedings from the 7th National
Cancer Conference, J.B. Lippincott, Philadelphia,
Pa., 1973.
Schein, P.S.; Kahn, R.; Gordon, P.; Wells, S.; DeVita,
V.T.: Streptozotocin for malignant insulinomas and
carcinoid tumor: Report of eight cases and review
of the literature. Archives of Internal Medicine 132:555-561,
1973.
Schein, P.S.; Delellis, R.A.; Kahn, R.; Kraft, A.R.;
Gorden, P.: Islet cell tumors: Current concepts and
management. Annals of Internal Medicine 79:239-257,
1973.
Schein, P.S.; Rakieten, N.; Cooney D.A.; Davis, R.;
Vernon, M.L.: Streptozotocin diabetes in monkeys and
dogs, and its prevention by nicotinamide. Proceedings
of the Society for Experimental Biology and Medicine
143:514-518, 1973.
Schein, P.S.; Cooney, D.A.; McMenamin, M.G.; Anderson,
T.: Streptozotocin diabetes - Further studies on the
mechanism of depression of nicotinamide adenine dinucleotide
concentrations in mouse pancreatic islets and liver.
Biochemical Pharmacology 22:2625-2631, 1973.
Young, R.C.; Walker, M.D.; Canellos, G.P.; Schein,
P.S.; Chabner, B.A.; DeVita, V.T.: Initial clinical
trials with methyl-CCNU, 1-(2-chloroethyl-3-(4-methyl-cyclohexyl)-
1-nitrosourea, (MeCCNU). Cancer 31:1164-1169, 1973.
Young, R.C.; Canellos, G.P.; Chabner, B.A.; Schein,
P.S.; DeVita, V.T.: Maintenance chemotherapy for advanced
Hodgkin's disease in remission. Lancet 1:1339-1343,
1973.
Schein, P.S.: Chemotherapeutic management of the
hormone-secreting endocrine malignancies. Cancer 30:1616-1626,
1972.
Schein, P.S.; Vickers, H.R.: Lupus vulgaris and Hodgkin's
disease. Archives of Dermatology 105:244-246, 1972.
Goldin, A.; Carter, S.; Homan, E.R.; Schein, P.S.:
Quanitative comparison of toxicity in animals and
man. The Design of Clinical Trials in Cancer Therapy.
Ed. M. Staquet, Editions Scientifiques Europeannes,
Brussels, 58-81, 1972.
Henry, M.C.; Blair, W.H.; Shefner, A.M.; Schein,
P.S.: Beagle dog as predictor of schedule - dependent
toxicity of 5-fluoro-2-deoxyuridine. Toxicol &
Applied Pharmacology 23:532-534, 1972.
Morganroth, J.; Deisseroth, A.; Winokur, S.; Schein,
P.S.: Differentiation of carcinomatous and bacterial
meningitis. Neurology 22:1240-1242, 1972.
Schein, P.S.; Yessayan, L.; Mayman, C.I.: Acute transverse
myelitis associated with intravenous opium. Neurology
21:101-102, 1971.
Rakieten, N.; Gordon, B.S. Beaty; A., Cooney; D.A.,
Davis; R.D., Schein; P.S.: Pancreatic islet cell tumors
produced by the combined action of streptozotocin
and nicotinamide. Proceedings of the Society for Experimental
Biology and Medicine 137:280-283, 1971.
Schein, P.S.; Alberti, K.G.M.M.; Williamson, D.H.:
Effects of streptozotocin on carbohydrate and lipid
metabolism in the rat. Endocrinology 89:827-834, 1971.
Alberti, K.G.M.M.; Houghton, C.R.S.; Schein, P.S.;
Williamson, D.H.: Experimental studies with glibenclamide
in the rat. Postgraduate Medical Journal 45 (December
Supplement) 9-15, 1970.
Schein, P.S.; Davis, R.D.; Carter, S.; Newman, J.;
Schein, D.R.; and Rall, D.P.: The evaluation of anticancer
drugs in dogs and monkeys for the prediction of qualitative
toxicities in man. Clinical Pharmacology Therapeutics
11:3-40, 1970.
Herman, E.H.; Schein, P.S.; Farmer, R.M.: Influence
of pharmacologic or physiologic pretreatment on acute
daunomycin (NSC-82151) cardiac toxicity in the hamster.
Toxicology and Applied Pharmacology 16:335-344, 1970.
Farmar, R.M.; Herman, E.H.; Schein, P.S.: Pathologic
changes induced by daunomycin (NSC-82151) in the Syrian
golden hamster. Cancer Chemotherapy Report 54:15-22,
1970.
Herman, E.H.; Schein, P.S.; Taylor, O.; Waravdekar,
V.S.: Effect of various antiarrhythmic drugs on the
daunomycin-induced arrhythmia in the hamster. Proceedings
of the Society for Experimental Biology and Medicine
133:69-72, 1970.
Rosen, S.; Schein, P.S.: Hemolytic-uremia syndrome
in an adult: Light and electron microscopic observations.
American Journal of Clinical Pathology 54:33-45, 1970.
Schein, P.S.: 1 Methyl-1-nitrosourea and dialkylnitrosamine
depression of nicotinamide adenine dinucleotide. Cancer
Research 29:1226-1232, 1969.
Schein, P.S.: 1-Methyl-1 nitrosoureas depression
of brain nicotinamide adeoune dinucleotide in the
production of neurologic toxicity. Proceedings of
the Society for Experimental Biology and Medicine
131:517-520, 1969.
Schein, P.S.; Rakieten, N.; Gordon, B.M.; Davis,
R.D.; Rall, D.P.: The toxicity of Escherichia coli
L-asparaginase. Cancer Research 29:426-434, 1969.
Herman, E.H.; Schein, P.S.; Farmar, R.M.: Comparative
cardiac toxicity of daunomycin in three rodent species.
Proceedings of the Society for Experimental Biology
and Medicine 130:1098-1102, 1969.
Schein, P.S.; Loftus, S.: Streptozotocin: Depression
of mouse liver pyridine nucleotides. Cancer Research
28:1501-1506, 1968.
Rakieten, N.; Gordon, B.S.; Cooney, D.A.; Davis,
R.D.; and Schein, P.S.: Renal tumorigenic action of
streptozotocin (NSC-85998) in rats. Cancer Chemotherapy
Report 52:563-567, 1968.
Schein, P.S.; Bates, R.W.: Plasma glucose levels
in normal and adrenalectomized mice treated with streptozotocin
and nicotinamide. Diabetes 18:760-765, 1968.
Kann, H.E.; Wells, J.H.; Gallelli, J.F.; Schein,
P.S.; Cooney, D.A.; Smith, E.R.; Seegmiller, J.E.;
Carbone, P.P.: The development and use of an intravenous
preparation of allopurinol. American Journal of Medical
Science 256:53-63, 1968.
Schein, P.S.; Cooney, D.A.; Vernon, M.L.: The use
of nicotinamide to modify the toxicity of streptozotocin
diabetes without loss of anti-tumor activity. Cancer
Research 27:2324-2332, 1967.
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