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Caroline Reinhold, M.D., M.Sc.
Medical Director, Oncology


Dr. Caroline Reinhold, M.D., M.Sc., Medical Director, Oncology, is a board-certified radiologist with over 15 years experience in clinical trials imaging. Dr. Reinhold is also Director of the Magnetic Resonance Unit, Research Director of the Radiology Department at McGill University and an internationally recognized leader in the field of body imaging. Dr. Reinhold supports our oncology program by providing scientific and regulatory expertise at the level of protocol design, imaging charter and analysis.

Her research has focused on developing and validating a number of surrogate imaging markers for studying diseases of the female pelvis. In addition, she has developed novel imaging methods for detecting and monitoring disease processes of the biliary tree and pancreas. She is also actively involved in the validation of new imaging methods and sits on a number of government and industry boards on technology assessment.

She has published more than 100 peer-reviewed articles, written numerous book chapters and co-edited two major imaging textbooks. She has served on several expert panels and standardization committees, most recently the ISMRM Ad Hoc Committee on Standards in Quantitative MR.  Dr. Reinhold is a grant reviewer for several Canadian and American funding agencies including the Canadian Institute of Health Research, Fonds de la Recherche en Santé du Québec, and the Radiological Society of North America.

Dr. Caroline Reinhold can be reached by phone at +1.415.722.4484 and by email at Caroline.Reinhold@Synarc.com

 
 

Scientific Publications:

Romagnuolo J, Bardou M, Rahme E, Joseph L, Reinhold C, Barkun, A.N. Magnetic Resonance Cholangiopancreatography: A Meta-Analysis of Test Performance in
Suspected Biliary Disease. Ann Intern Med. 2003; 139:547-557

Chaudhry S, Reinhold C, Guermazi A, Khalili I, Maheshwari S. Benign and Malignant
Diseases of the Endometrium.
Topics in Magnetic Resonance Imaging. Aug 2003; 14(4): 339-357

Ascher S, Jha R.C, Reinhold C. Benign Myometrial Conditions: Leiomyomas and
Adenomyosis.
Topics in Magnetic Resonance Imaging. Aug 2003; 14(4): 281-304

Noone TC, Semelka RC, Chaney DM, Reinhold C. Abdominal imaging studies: comparison
of diagnostic accuracies resulting from ultrasound, computed tomography, and magnetic
resonance imaging in the same individual. Magn Reson Imaging. Jan 2004;22(1):19-24

Pressacco J, Casey M, Reinhold C. Magnetic resonance and ultrasound images of hepatic
adenomatosis. Radiology, submitted, 2004.

Casey M, Pressacco J, Reinhold C. Ghostly Gallbladder. Radiology, accepted, 2004.

Kothari M, Guermazi A, White D, Suhy J, Reinhold C. Imaging in antiangiogenesis trial: a clinical trials radiology perspective. Br J Radiol. 2003; 76: S92-S96

Joseph L, Reinhold C. Statistical inference for continuous variables. AJR. 2005;184:1047-1056

Joseph L, Reinhold C. Statistical inference for proportions. AJR. 2005;184:1057-1064

Gallix P, Bret PM, Atri M, Lecesne R, Reinhold C. Comparison of qualitative and quantitative measurements on unenhanced T1-weighted fat saturation MR images in predicting pancreatic pathology. J Magn Reson Imaging. 2005;21(5):583.

Alfuhaid T, Reinhold C. Pelvic actinomycosis associated with intrauterine device use: case report. Can Assoc Radiol J. 2003 Jun;54(3):160-2.

Joseph L, Reinhold C. Fundamentals of clinical research for radiologists. Introduction to probability theory and sampling distributions. AJR Am J Roentgenol. 2003 Apr;180(4):917-23.

Vuong T, Belliveau PJ, Michel RP, Moftah BA, Parent J, Trudel JL, Reinhold C, Souhami L. Conformal Preoperative Endorectal Brachytherapy Treatment for Locally Advanced Rectal Cancer: Early Results of a Phase I/II Study. Dis Colon Rectum. 2002 Nov;45(11):1486-95.

Ascher SM, Reinhold C. Imaging of cancer of the endometrium. Radiol Clin North Am. 2002 May;40(3):563-76. Review.

Gallix BP, Reinhold C, Dauzat M, Bret PM. Streamlined flow in the portal vein: demonstration with MR angiography. J Magn Reson Imaging. 2002 May;15(5):603-9.

Reinhold C, Khalili I. Postmenopausal bleeding: value of imaging. Radiol Clin North Am. 2002 May;40(3):527-62. Review.

Menon K, Barkun AN, Romagnuolo J, Friedman G, Mehta SN, Reinhold C, Bret PM. Patient satisfaction after MRCP and ERCP. Am J Gastroenterol. 2001 Sep;96(9):2646-50.

Audet P, Pressacco J, Burke M, Reinhold C. MR imaging of female pelvic malignancies. Magn Reson Imaging Clin N Am. 2000 Nov;8(4):887-914. Review.

Atri M, Chow CM, Kintzen G, Gillett P, Aldis AA, Thibodeau M, Reinhold C, Bret PM. Expectant treatment of ectopic pregnancies: clinical and sonographic predictors. AJR Am J Roentgenol. 2001 Jan;176(1):123-7.

Menon K, Barkun AN, Romagnuolo J, Friedman G, Mehta SN, Reinhold C, Bret PM. Patient satisfaction after MRCP and ERCP. Am J Gastroenterol. 2001 Sep;96(9):2646-50

Beam C, Blackmore C, Karlik S, Reinhold C. Editors' introduction to the series. AJR Am J Roentgenol. 2001 Feb;176(2):323-5.

Audet P, Pressacco J, Burke M, Reinhold C. MR imaging of female pelvic malignancies. Magn Reson Imaging Clin N Am. 2000 Nov;8(4):887-914. Review

Atri M, Chow CM, Kintzen G, Gillett P, Aldis AA, Thibodeau M, Reinhold C, Bret PM. Expectant treatment of ectopic pregnancies: clinical and sonographic predictors. AJR Am J Roentgenol. 2001 Jan;176(1):123-7

Tafazoli F, Taylor J, McFarland EG, Gianfelice D, Lepanto L, Reinhold C. New imaging techniques for the evaluation of gastrointestinal diseases. Can J Gastroenterol. 2000 Nov;14 Suppl D:163D-180D. Review

Atri M, Reinhold C, Mehio AR, Chapman WB, Bret PM. Adenomyosis: US features with histologic correlation in an in-vitro study. Radiology. 2000 Jun;215(3):783-90.

Coche EE, Bret PM, Reinhold C. Dynamic enhancement of upper abdominal organs in normal volunteers with MRI and effects of contrast dose reduction. Abdom Imaging. 1999 Nov-Dec;24(6):604-9.

Garcia P, Genin G, Bret PM, Bonaldi VM, Reinhold C, Atri M. Hepatic CT enhancement: effect of the rate and volume of contrast medium injection in an animal model. Abdom Imaging. 1999 Nov-Dec;24(6):597-603.

Reinhold C, Tafazoli F, Mehio A, Wang L, Atri M, Siegelman ES, Rohoman L. Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. Radiographics. 1999 Oct;19 Spec No:S147-60. Review

Garant M, Belley G, Reinhold C. Residents' corner. Answer to case of the month #63. Inflammatory aneurysm of the abdominal aorta. Can Assoc Radiol J. 1999 Aug;50(4):275-7.

Tafazoli F, Reinhold C. Uterine adenomyosis: current concepts in imaging. Semin Ultrasound CT MR. 1999 Aug;20(4):267-77. Review.

Lecesne R, Taourel P, Bret PM, Atri M, Reinhold C. Acute pancreatitis: interobserver agreement and correlation of CT and MR cholangiopancreatography with outcome. Radiology. 1999 Jun;211(3):727-35

Semelka RC, Balci NC, Op de Beeck B, Reinhold C. Evaluation of a 10-minute comprehensive MR imaging examination of the upper abdomen. Radiology. 1999 Apr;211(1):189-95.

Garant M, Trudeau M, Reinhold C, Bret PM. Liver metastasis: comparison of 2 methods for reporting of disease in patients receiving chemotherapy. Can Assoc Radiol J. 1999 Feb;50(1):13-6.

Reinhold C, Tafazoli F, Wang L. Imaging features of adenomyosis. Hum Reprod Update. 1998 Jul-Aug;4(4):337-49. Review. Reinhold C, Taourel P, Bret PM, Cortas GA, Mehta SN, Barkun AN, Wang L, Tafazoli F. Choledocholithiasis: evaluation of MR cholangiography for diagnosis. Radiology. 1998 Nov;209(2):435-42

Truong M, Atri M, Bret PM, Reinhold C, Kintzen G, Thibodeau M, Aldis AE, Chang Y. Sonographic appearance of benign and malignant conditions of the colon. AJR Am J Roentgenol. 1998 Jun;170(6):1451-5.

David V, Reinhold C, Hochman M, Chuttani R, McKee J, Waxman I, Wang L, Li W, Kaplan R, Edelman RR. Pitfalls in the interpretation of MR cholangiopancreatography. AJR Am J Roentgenol. 1998 Apr;170(4):1055-9.

Kelekis NL, Semelka RC, Worawattanakul S, de Lange EE, Ascher SM, Ahn IO, Reinhold C, Remer EM, Brown JJ, Bis KG, Woosley JT, Mitchell DG. Hepatocellular carcinoma in North America: a multiinstitutional study of appearance on T1-weighted, T2-weighted, and serial gadolinium-enhanced gradient-echo images. AJR Am J Roentgenol. 1998 Apr;170(4):1005-13.

Bonaldi VM, Bret PM, Atri M, Reinhold C. Helical CT of the pancreas: a comparison of cine display and film-based viewing. AJR Am J Roentgenol. 1998 Feb;170(2):373-6.

Lecesne R, Stein L, Reinhold C, Bret PM. MR cholangiopancreatography of annular pancreas. J Comput Assist Tomogr. 1998 Jan-Feb;22(1):85-6.

Bret PM, Reinhold C. Magnetic resonance cholangiopancreatography. Endoscopy. 1997 Aug;29(6):472-86. Review.

Feldman L, Philpotts LE, Reinhold C, Duguid WP, Rosenberg L. Pancreatic schwannoma: report of two cases and review of the literature. Pancreas. 1997 Jul;15(1):99-105. Review

Reinhold C, Hricak H, Forstner R, Ascher SM, Bret PM, Meyer WR, Semelka RC. Primary amenorrhea: evaluation with MR imaging. Radiology. 1997 May;203(2):383-90.

Garcia P, Bonaldi V, Bret PM, Liang L, Atri M, Reinhold C. Effect of portal venous flow augmentation on liver enhancement with CT. Abdom Imaging. 1997 May-Jun;22(3):277-80.

Pavone E, Mehta SN, Trudel J, Reinhold C, Bret P, Barkun AN. Torsion of an appendix epiploica: a nonsurgical cause of acute abdomen. Dig Dis Sci. 1997 Apr;42(4):851-2. No abstract available.

Magnetic resonance cholangiopancreatography. Gastrointest Endosc Clin N Am. 1997 Apr;7(2):247-70. Review.

Kelekis NL, Semelka RC, Siegelman ES, Ascher SM, Outwater EK, Woosley JT, Reinhold C, Mitchell DG. Focal hepatic lymphoma: magnetic resonance demonstration using current techniques including gadolinium enhancement. Magn Reson Imaging. 1997;15(6):625-36.

Burdeny DA, Semelka RC, Kelekis NL, Reinhold C, Ascher SM. Small (< 1.5 cm) angiomyolipomas of the kidney: characterization by the combined use of in-phase and fat-attenuated MR techniques. Magn Reson Imaging. 1997;15(2):141-5.

Semelka RC, Hricak H, Kim B, Forstner R, Bis KG, Ascher SM, Reinhold C. Pelvic fistulas: appearances on MR images. Abdom Imaging. 1997 Jan-Feb;22(1):91-5.

Ramani M, Reinhold C, Semelka RC, Siegelman ES, Liang L, Ascher SM, Brown JJ, Eisen RN, Bret PM. Splenic hemangiomas and hamartomas: MR imaging characteristics of 28 lesions. Radiology. 1997 Jan;202(1):166-72

Atri M, Leduc C, Gillett P, Bret PM, Reinhold C, Kintzen G, Aldis AE, Thibodeau M. Role of endovaginal sonography in the diagnosis and management of ectopic pregnancy. Radiographics. 1996 Jul;16(4):755-74; discussion 775. Review

Bonaldi VM, Bret PM, Atri M, Garcia P, Reinhold C. A comparison of two injection protocols using helical and dynamic acquisitions in CT examinations of the pancreas. AJR Am J Roentgenol. 1996 Jul;167(1):49-55.

Atri M, Herba MJ, Reinhold C, Leclerc J, Ye S, Illescas FF, Bret PM. Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients. AJR Am J Roentgenol. 1996 Jun;166(6):1361-7.

Reinhold C, Bret PM. Current status of MR cholangiopancreatography. AJR Am J Roentgenol. 1996 Jun;166(6):1285-95.

Taourel P, Bret PM, Reinhold C, Barkun AN, Atri M. Anatomic variants of the biliary tree: diagnosis with MR cholangiopancreatography. Radiology. 1996 May;199(2):521-7.

Bret PM, Reinhold C, Taourel P, Guibaud L, Atri M, Barkun AN. Pancreas divisum: evaluation with MR cholangiopancreatography. Radiology. 1996 Apr;199(1):99-103.

Garcia PA, Bonaldi VM, Bret PM, Liang L, Reinhold C, Atri M. Effect of rate of contrast medium injection on hepatic enhancement at CT. Radiology. 1996 Apr;199(1):185-9.

Reinhold C, McCarthy S, Bret PM, Mehio A, Atri M, Zakarian R, Glaude Y, Liang L, Seymour RJ. Diffuse adenomyosis: comparison of endovaginal US and MR imaging with histopathologic correlation. Radiology. 1996 Apr;199(1):151-8

Garant M, Reinhold C. Residents' corner. Answer to case of the month #36. Hepatic lipoma. Can Assoc Radiol J. 1996 Apr;47(2):140-2. No abstract available

Garant M, Reinhold C. Dermoid cyst of the ovary: computed tomography diagnosis of an unusual case. Can Assoc Radiol J. 1996 Apr;47(2):107-10. Review.

Reinhold C, Bret PM. MR cholangiopancreatography. Abdom Imaging. 1996 Mar-Apr;21(2):105-16. Review

Loud PA, Semelka RC, Kettritz U, Brown JJ, Reinhold C. MRI of acute cholecystitis: comparison with the normal gallbladder and other entities. Magn Reson Imaging. 1996;14(4):349-55.

Bonaldi VM, Bret PM, Reinhold C, Atri M. Comparison of helical and conventional computed tomography of the liver. Can Assoc Radiol J. 1995 Dec;46(6):443-8.

Reinhold C, Atri M, Mehio A, Zakarian R, Aldis AE, Bret PM. Diffuse uterine adenomyosis: morphologic criteria and diagnostic accuracy of endovaginal sonography. Radiology. 1995 Dec;197(3):609-14

Bonaldi VM, Bret PM, Reinhold C, Atri M. Helical CT of the liver: value of an early hepatic arterial phase. Radiology. 1995 Nov;197(2):357-63.

Guibaud L, Bret PM, Reinhold C, Atri M, Barkun AN. Bile duct obstruction and choledocholithiasis: diagnosis with MR cholangiography. Radiology. 1995 Oct;197(1):109-15.

Garant M, Genin G, Reinhold C. Enterovesical fistula in a patient with B-cell lymphoma. Can Assoc Radiol J. 1995 Oct;46(5):395-7

Reinhold C, Guibaud L, Genin G, Bret PM. MR cholangiopancreatography: comparison between two-dimensional fast spin-echo and three-dimensional gradient-echo pulse sequences. J Magn Reson Imaging. 1995 Jul-Aug;5(4):379-84

Reinhold C, Hammers L, Taylor CR, Quedens-Case CL, Holland CK, Taylor KJ. Characterization of focal hepatic lesions with duplex sonography: findings in 198 patients. AJR Am J Roentgenol. 1995 May;164(5):1131-5.

Guibaud L, Bret PM, Reinhold C, Atri M, Barkun AN. Diagnosis of choledocholithiasis: value of MR cholangiography. AJR Am J Roentgenol. 1994 Oct;163(4):847-50

Atri M, Nazarnia S, Bret PM, Aldis AE, Kintzen G, Reinhold C. Endovaginal sonographic appearance of benign ovarian masses. Radiographics. 1994 Jul;14(4):747-60; discussion 761-2.

Atri M, Nazarnia S, Aldis AE, Reinhold C, Bret PM, Kintzen G. Transvaginal US appearance of endometrial abnormalities. Radiographics. 1994 May;14(3):483-92.

Kappus H, Reinhold C. Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants. Toxicol Lett. 1994 Apr;71(2):105-9

Smith RC, Constable RT, Reinhold C, McCauley T, Lange RC, McCarthy S. Fast spin echo STIR imaging. J Comput Assist Tomogr. 1994 Mar-Apr;18(2):209-13.

Atri M, Nazarnia S, Mehio A, Reinhold C, Bret PM. Hypoechogenic embryologic ventral aspect of the head and uncinate process of the pancreas: in vitro correlation of US with histopathologic findings. Radiology. 1994 Feb;190(2):441-4

Petit P, Bret PM, Lough JO, Reinhold C. Risks associated with intestinal perforation during experimental percutaneous drainage. Invest Radiol. 1992 Dec;27(12):1012-9. PMID:

Smith RC, Reinhold C, McCauley TR, Lange RC, Constable RT, Kier R, McCarthy S. Multicoil high-resolution fast spin-echo MR imaging of the female pelvis. Radiology. 1992 Sep;184(3):671-5.

Smith RC, Reinhold C, Lange RC, McCauley TR, Kier R, McCarthy S. Fast spin-echo MR imaging of the female pelvis. Part I. Use of a whole-volume coil. Radiology. 1992 Sep;184(3):665-9

Leslie WD, Reinhold C, Rosenthall L, Tau C, Glorieux FH. Panostotic fibrous dysplasia. A new craniotubular dysplasia. Clin Nucl Med. 1992 Jul;17(7):556-60

Kappus H, Reinhold C. Inhibition of bleomycin-induced toxic effects by antioxidants in human malignant melanoma cells. Adv Exp Med Biol. 1990;264:345-8

Reinhold C, Illescas FF, Atri M, Bret PM. Treatment of pleural effusions and pneumothorax with catheters placed percutaneously under imaging guidance. AJR Am J Roentgenol. 1989 Jun;152(6):1189-91

Reinhold CE, Nickolai DJ, Piccinini TE, Byford BA, York MK, Brooks GF. Evaluation of broth media for routine culture of cerebrospinal and joint fluid specimens. Am J Clin Pathol. 1988 May;89(5):671-4.

Bret PM, Reinhold C, Herba M, Atri M, Challender J, Edde D, Casola G, Kintzen G, Withers C, Remy H. Replaced or right accessory hepatic artery: can ultrasound replace angiography? J Clin Ultrasound. 1988 May;16(4):245-9

Demas BE, Hricak H, Williams RD, Leibel S, Reinhold C, Higgins CB. Magnetic resonance imaging evaluation of radiation-induced changes in experimentally implanted renal cell carcinoma. Invest Radiol. 1987 Mar;22(3):206-8.

Kappus H, Reinhold C, Artuc M. Photodynamic toxicity of hematoporphyrin derivatives to human keratinocytes in culture. Mol Toxicol. 1987-88 Fall;1(4):295-9

Engelstad BL, Spitler LE, Del Rio MJ, Ramos EC, Rosendorf LL, Reinhold CE, Khentigan A, Huberty JP, Corpuz SW, Lee HM, et al. Phase 1 immunolymphoscintigraphy with an In-111-labeled antimelanoma monoclonal antibody. Radiology. 1986 Nov;161(2):419-22

Terrier F, Revel D, Reinhold CE, Levine J, Grodd W, Genant HK, Brasch RC. Contrast-enhanced MRI of periarticular soft-tissue changes in experimental arthritis of the rat. Magn Reson Med. 1986 Jun;3(3):385-96.

Terrier F, Revel D, Hricak H, Alpers CE, Reinhold CE, Levine J, Higgins CB. Changes in proton relaxation times of the rat spleen during adjuvant-induced immunologic reaction. Invest Radiol. 1986 Mar;21(3):221-6

Hricak H, Tscholakoff D, Heinrichs L, Fisher MR, Dooms GC, Reinhold C, Jaffe RB. Uterine leiomyomas: correlation of MR, histopathologic findings, and symptoms. Radiology. 1986 Feb;158(2):385-91.

Terrier F, Hricak H, Revel D, Alpers CE, Reinhold CE, Levine J, Genant HK. Magnetic resonance imaging and spectroscopy of the periarticular inflammatory soft-tissue changes in experimental arthritis of the rat. Invest Radiol. 1985 Nov;20(8):813-23.

Fisher M, Hricak H, Reinhold C, Proctor E, Williams R. Female urethral carcinoma: MRI staging. AJR Am J Roentgenol. 1985 Mar;144(3):603-4.

Steinmetz N, Furesz J, Reinhold C, Yarosh W. Storage conditions of live measles, mumps and rubella virus vaccines in Montreal. Can Med Assoc J. 1983 Jan 15;128(2):162-3

Reinhold C, Hartwig HG. Progress in microfluorometric identification of monoamine fluorophores. Brain Res Bull. 1982 Jul-Dec;9(1-6):97-105.

Scheuermann DW, Stilman C, Reinhold C, De Groodt-Lasseel MH. Microspectrofluorometric study of monoamines in the auricle of the heart of Protopterus aethiopicus. Cell Tissue Res. 1981;217(2):443-9.

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