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Carol S. Portlock, M.D.
Lymphoma


Carol S. Portlock, M.D., is an attending physician at Memorial Sloan Kettering Cancer Center in New York. Dr. Portlock is a board certified Oncologists and is an internationally recognized expert in Hodgkin's and non-Hodgkin's lymphomas. Her research focuses on new therapies for lymphoma, including initial stem-cell transplantation and immunotherapy.

Dr. Portlock has received numerous awards and honors including the Evelyn Hoffman Memorial Award from the Lymphoma Research Foundation of America in 1988 and the Ettinger Prize from the American Cancer Society in 1986.  She has served as a consultant to the Oncologic Drug Advisory Committee of the Food and Drug Administration. In addition she serves on a variety of scientific advisory boards in industry and lymphoma research foundations.

 
 

Scientific Publications:

Shia J, Teruya-Feldstein J, Pan D, Hedge A, Klimstra DS, Chaganti RSK, Qin J, Portlock CS, Filippa DA: Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathological study of 26 cases. Amer J Surg Path Feb 2002;26(2):216-224.

Laurie SA, Kris MG, Portlock CS, Rosenzweig KE, Miller VA, Krug LM, Rusch VW: The clinical course of non small cell lung cancer in survivors of Hodgkin's disease. Cancer 2002;95(1):119-26.

Ripp JA, Louie DS, Chan W, Nawaz H. Portlock CS: T-cell rich B-cell lymphoma: clinical distinctiveness and response to treatment in 45 patients. Leuk Lymphoma 2002 Aug;43(8):1573-80.

Pan D, Moskowitz CH, Zelenetz AD, Straus D, Kewalaramani T, Noy A, Qin J, Teruya-Feldstein J, Portlock CS: Rituximab for aggressive non-Hodgkin's lymphomas relapsing after or refractory to autologous stem cell transplantation. Cancer J. 2002 Sep-Oct;8(5):371-6.

Pan D, Qin J, Farber C, O'Brien J, Filippa D, Portlock CS: CHOP with high dose Cyclophosphamide consolidation vs CHOP alone as initial therapy for advanced stage, indolent non-Hodgkin's lymphoma. Leuk Lymphoma, 2002 (in press).

Portlock CS: "Stanford V and Radiotherapy for Hodgkin's Disease" Current Oncology Reports 2002;4(5):413.

Portlock CS: "CHOP and Rituximab in Elderly Patients" Current Oncology Reports 2002;4(5):414.

Portlock CS: "Dose density and dose intensity: where does CHOP go from here?" Ann Oncol 2002;13:1329-1330.

Goy A, Gilles F, Remache Y, Filippa D, Portlock CS, Jhanwar SC, Zelenetz AD: Establishment of a human cell line (SKI-DLCL-1) with a t(1;14)(q21;q32) translocation from the ascites of a patient with diffuse large cell lymphoma. Leuk Lymphoma Jan 2001;40(3-4):419-23.

Moskowitz G, Nimer SD, Zelenetz AD, Trippett T, Hedrick EE, Filippa D, Louie D, Gonzales M, Walits J, Coady-Lyons N, Qin J, Frank R, Bertino JR, Goy A, Noy A, O'Brien JP, Straus D, Portlock CS, Yahalom J: A two-step comprehensive high-dose chemotherapy second-line program for relapsed and refractory Hodgkin's disease: analysis by intent to treat and development of a prognostic model. Blood Feb 2001;97(3):616-623.

Donnelly GB, Glassman J, Long C, Torres P, Straus DJ, O'Brien JP, Bertino J, Moskowitz CH, Zelenetz AD, Portlock CS: Granulocyte-colony stimulating factor (G-CSF) may improve disease outcome in elderly patients with diffuse large cell lymphoma (DLCL) treated with CHOP chemotherapy. Leuk Lymphoma 2000;39(1-2):67-75.

Portlock CS: "New developments in lymphoma clinical trials" Current Oncology Reports 2000;2:154-156.

Moskowitz CH, Nimer SD, Glassman JR, Portlock CS, Yahalom J, Straus DJ, O'Brien JP, Elkin N, Bertino JR, Zelenetz AD: The International Prognostic Index predicts for outcome following autologous stem cell transplantation in patients with relapsed and primary refractory intermediate-grade lymphoma. Bone Marrow Transplant 1999;23(6):561-7.

Moskowitz CH, Bertino JR, Glassman JR, Hedrick EE, Hunte S, Coady-Lyons N, Agus DB, Goy A, Jurcic J, Noy A, O'Brien J, Portlock CS, Straus DS, Childs B, Frank R, Yahalom J, Filippa D, Louie D, Nimer SD, Zelenetz AD: Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin's lymphoma. J Clin Oncol 1999;17(12): 3776-85.
Schechter NR, Portlock CS, and Yahalom J: Treatment ofMucosa-Associated Lymphoid Tissue Lymphoma of the Stomach with Radiation Alone. J Clin Oncol 1998;16:1916-1921.

Gale RP, Park RE, DuBois R, Bierman PJ, Fisher RI, Loh KK, Peterson BA, Phillips GL, Portlock CS, Rosenblum D, Armitage JO: Delphi-panel Analysis of Appropriateness of High-Dose Chemotherapy and Blood Cell or Bone Marrow Autotransplants in Diffuse Large Cell Lymphoma. Leukemia and Lymphoma 1998;32(1-2):139-140.

Pavlick A, Gerdes H, Portlock C: "Endoscopic Ultrasound (EUS) in the Evaluation of Gastric Small Lymphocytic Mucosa-Associated Lymphoid Tumors (MALT)." J Clin Oncol 1997;15:1761-1766.

Hirsch A, Vander-Els N, Gomez E, Leung D, Portlock C, Straus D, and Yahalom J: "The Effect of ABVD Chemotherapy With and Without Mediastinal Irradiation on Pulmonary Function and Symptoms in Early Stage Hodgkin's Disease." J Clin Oncol 1996;14:1297-1305.

Wong ET, Portlock CS, O'Brien JP, DeAngelis LA: "Chemo-sensitive Epidural Spinal Cord Disease in Non-Hodgkin's Lymphoma" Neurology 1996;46:1543-1547.

Filippa DA, Ladanyi M, Wollner N, Straus DJ, O'Brien JP, Portlock C, Gangi M and Sun M: "CD 30 (Ki-1)-Positive Malignant Lymphomas: Clinical, Immunophenotypic, Histologic, and Genetic Characteristics and Differences with Hodgkin's Disease." Blood April 1996;87(7):2905-2917.

Castellino RA, Hilton S, O'Brien JP, and Portlock CS: "Non-Hodgkin Lymphoma: Contribution of Chest CT in the Initial Staging Evaluation." Radiology 1996;199:129-132.

Lieberman FS, Portlock C: "Recurrent Episodes of Transient Memory Disturbance After Unilateral Thalamic Infarction in a Hodgkin's Disease Patient With Herpes Zoster." Journal of Neurovascular Disease July/Aug 1996:9-11.

Younes A, Cabanillas P, McLaughlin PW, Hagemeister FB, Farber C, Sarris A, Pate O, Myers J, and Portlock C: "Preliminary Experience with Paclitaxel for the Treatment of Relapsed and Refractory Hodgkin's Disease." Annals of Oncology 1996;7:1083-1085.

Offit K, LoCoco F, Louie D, Parsa N, Leung D, Portlock C, Ye B, Lista F, Filippa D, Rosenbaum A, Ladanyi M, Jhanwar S, Dalla-Favera R, and Chaganti R. "Rearrangement of the bcl-6 Gene as a Prognostic Marker in Diffuse Large Cell Lymphoma" N Eng J Med 1994;331(2):74-80.

O'Brien JP, O'Keefe P, Alvares A, and Portlock, CS. "The NHL-15 Protocol for Intermediate Grade and Immunoblastic LYmphoma: A Dose intense program of Doxorubicin, Vincristine and Cyclophosphamide" Hem/Onc Annals 1993;1:47-50.

Yahalom J, Gulati CS, Toia M, Maslak P, McCarron EG, O'Brien JP, Portlock CS, Straus DJ, Phillips J, and Fuks Z. "Accelerated Hyperfractionated Total-Lymphoid Irradiation, High-Dose Chemotherapy and Autologous Bone Marrow Transplantation for Refractory and Relapsing Patients with Hodgkin's Disease" J Clin Oncol 1993;11:1062-1070.

Atiq OT, Deangelis LM, Rosenblum M, and Portlock. "Cutaneous T-cell lymphoma presenting with diffuse lymphomatous infiltration of the peripheral nerves: Response to combination chemotherapy" Am J Clin Oncol 1992;15:212-215.

Kostak L, Yeh SDJ, Portlock CS, Heelan R, Tao T-J, Niedzwiecki D, and Larson SM. "Validation of Ga-67 Citrate, Single Photon Emission Computed Tomography (SPECT) in Biopsy Confirmed Residual Hodgkin's Disease in the Mediastinum" J Nucl Med 1992;33:345-350.

Portlock CS: "Management of Non-Hodgkin's lymphoma" Int J Clin Lab Res 1992;22(2):81-83.

Portlock CS: ?Greater curability in advanced Hodgkin's disease?? Cancer J Sci Am 1999 Sept-Oct;5(5):264-5.

Golomb HM, Fefer A, Golde DW, Ozer H, Portlock CS, Silber R, Rappeport J, Ratain MJ, Thompson J, Bonnem E, Spiegel R, Tensen L, Burke JS, and Vardiman JW. "Survival experience of 195 patients with hairy cell leukemia treated in a multi-institutional study with interferon-alfa 2B" Leukemia and Lymphoma, 1991.

Murren JR, DeRosa W, Durviage HJ, Davis C, Makuch R, and Portlock CS. "High-dose cisplatin plus dacarbazine in the treatment of metastatic melanoma" Cancer 1991;67:1514.

Subhash C. Gulati, Kathy Jules-Elysee, Karla Whitmarsh, Joachim Yahalom, M.D., Lillian Reich, John Crown, Robert Motzer, Morton Coleman, Roberto M. Lemoli, Bayard D. Clarkson, Carol Portlock, Timothy Gee, and John Mendelsohn. "Factors Affecting The Outcome of Autologous Bone Marrow Transplantation" Autologous Bone Marrow Transplantation, ed. Karen A. Dicke, James O. Armitage and Mary Jean Dicke-Evinger, 1991:405-410.

Mai DH-W, Peschel RE, Portlock C, Knowlton A, and Farber L. "Stage I and II subdiaphragmatic Hodgkin's disease" Cancer 1991;68:1476-1481.

Thomas A. Steffens, Dean F. Bajorin, Paul B. Chapman, David R. Lovett, Beverly V. Cody-Johnson, Mary Agnes Templeton, Robert T. Heelan, George Y. Wong, Carol S. Portlock, Herbert F. Oettgen and Alan N. Houghton. "A Phase II Trial of High-Dose Cisplatin and Dacarbazine" Cancer 1991;68:1230-1237.

Gulati S, Portlock CS, Yahalom J: "Autologous Bone Marrow Transplantation" Current Problems in Cancer 1991;15(1):1-57.

Murren JR and Portlock CS. "Non-Hodgkin's lymphoma: Current Therapy for low grade histologies" Adv Oncol 1991;7:9-14.

Dowling SW, Peschel RE, Portlock CS, Kramer C, Farber LR, and Knowlton AH. "Mediastinal irradiation in combined modality therapy for Hodgkin's disease" Int J Radiat Oncol Biol Phys 1990;19:543-546.

Henry-Amar M and Somers R (CS Portlock, Contributor), "Survival outcome after Hodgkin's disease: A report from the International data base on Hodgkin's disease" Semin Oncol 1990;17:758-768.

Portlock CS. "Non-Hodgkin's lymphomas: Advances in diagnosis, staging and management" Cancer 1990;65:718-722.

Portlock CS. "Management of the low-grade non-Hodgkin's lymphomas" Semin Oncol 1990;17:51-59.

Portlock CS. "Advances in the treatment of lymphoma" Current Opinion in Oncology 1990;2:838-842.

Golomb H, Ratain MJ, Fefer A, Golde DW, Ozer H, Portlock CS, et al. "A randomized study of the duration of treatment with interferon alpha-2b in hairy cell leukemia patients" J Natl Cancer Inst 1988;80:369-373.

Schneider KC, Lichtenstein JL, Freeman JL, Newbold RC, Fetter RB, Gottlieb L, Leaf PJ, and Portlock CS. "Ambulatory visit groups: An outpatient classification system" J Ambulatory Care Manage 1988;11:1-12.

Golomb HM, Fefer A, Golde DW, Ozer H, Portlock CS, et al. "Report of a multi-institutional study of 193 patients with hairy cell leukemia treated with interferon-alfa 2b" Semin Oncol 1988;15(5):7-9.

Portlock CS. "GI tract lymphomas: The pathologists' new diagnostic tools" J Clin Gastroenterol 1988;10:135-136.

Golomb HM, Fefer A, Golde DW, Ozer H, Portlock CS, et al. "Sequential Evaluation of Alpha-2-Interferon Treatment in 128 Patients with Hairy Cell Leukemia" Semin Oncol 1987;14:13-17.

Leavitt RD Rantanatharathorn B, Ozer H, Ultman JE, Portlock CS, et al. "Alpha-2b interferon in the treatment of Hodgkin's disease and non-Hodgkin's lymphoma" Semin Oncol XIV (Suppl 2) 1987:18-23.

Portlock CS, Fischer DS, Cadman E, et al. "High-dose pulse chlorambucil in advanced, low grade non-Hodgkin's lymphomas" Cancer Treat Rep 1987;71:1029-1031.

Portlock CS. "Alpha Interferon in the Treatment of Non-Hodgkin's Lymphomas" Current Concepts in Oncology 1987;9:2-6.

Koletsky AJ, Bertino JR, Farber LR, Prosnitz LR, Kapp DS, Fischer D, and Portlock CS. "Second Neoplasms in Patients with Hodgkin's Disease Following Combined Modality Therapy" J Clin Oncol 1986;4:311-317.

Golomb HM, Jacobs A, Fefer A, Ozer H, Thompson J, Portlock CS, Ratain M, Golde D, Vardimen J, Burke JS, Brady J, Bonnem E, and Spiegel R. "Alpha-2-Interferon Therapy of Hairy Cell Leukemia: A Multi-center study of 64 patients" J Clin Oncol 1986;4:900-905.

Todd MB, Cadman EC, Newcomer LN, Holford TR, Farber LR, Fischer DS, Waldron JA, Portlock CS, Camp B, Bertino JR. "ACOMLA and COMLA for malignant lymphoma" in Update on Treatment for Diffuse Large Cell Lymphoma, ed. AT Skarin, Park Row Publishers, Inc. 1986;53-61.

Todd MB, Portlock CS, Farber LR, Holford TR, and Bertino JR. "Prognostic Indicators in diffuse large cell (histiocytic) lymphoma" Int J Radiat Oncol Biol Phys 1986;12:593-601.

Krikorian JG, Portlock CS, and Mauch PM. "Hodgkin's disease presenting below the diaphragm" J Clin Oncol 1986;4:1551-1562.

Portlock CS. "Non-Hodgkin's Lymphoma" In Hematologic Malignancies, ed. B. Hoogstraten. (Springer-Verlag, Berlin), 1986:77-96.

Portlock CS. "Therapeutic Approaches to the Treatment of Hairy Cell Leukemia" Semin Oncol 1986;13:55-59.

Leavitt RD, Kaplan S, Grimm M, Ozer H, Portlock CS, Ratanatharathorn V, Kararnes C, Ultmann J, and Rudnick S. "High and Low Dose Treatment for High and Low Grade Non-Hodgkin's Lymphoma" Interferon Alpha-2: Pre-Clinical and Clinical Evaluation (DL Kisner and JF Smyth, ed.), Martinus Nijoff Publishers, 1985:57-73.

Carmen MD, Schornagel JH, Rivest RS, Srimatkandada S, Portlock CS, Duffy TP, and Bertino JR. "Resistance to Methotrexate Due to Gene Amplification in a Patient with Acute Leukemia" J Clin Oncol 1984;2:16-20.

Luikart SH, Whitman GB, Portlock CS. "Adriamycin, Vinblastine, and Mitomycin C Combination Chemotherapy in Refractory Breast Carcinoma" Cancer 1984;54:1252-1255.

Portlock CS. "Hodgkin's Disease" Medical Clin N Amer 1984;68:729-740.

Portlock CS. "Good Risk Non-Hodgkin's Lymphoma: Aproaches to Management" Semin Hematol 1983;20:25-34.

Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF, Portlock CS, and Minna JD. "Deletion 3p (14-23) Double Minute Chromosomes, and Homogeneously Staining Regions in Human Small Cell Lung Cancer in Gene Amplification" Robert T. Schimke, ed., Cold Spring Harbor Laboratory, 1982.

Portlock CS. "The Deferral of Initial Therapy in Advanced Indolent Lymphomas" Cancer Treat Rep March 1982;66:417-419.

Torti FM, Portlock CS, Rosenberg SA, and Kaplan HS. "Extralymphatic Hodgkin's Disease: Prognosis and Response to Therapy" Amer J Med 1981;70:487-492.

Krikorian JG, Portlock CS, Cooney DP, and Rosenberg SA. "Spontaneous Regression of Non-Hodgkin's Lymphoma. A Report of Nine Cases" Cancer 1980;46:2093-2099.

Portlock CS. "Management of the Indolent Non-Hodgkin's Lymphomas" Semin Oncol 1980;7:292-301.

Portlock CS and Rosenberg SA. "No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types" Ann Intern Med 1979;90:10-13.

Hoppe RT, Portlock CS, Glatstein E, Rosenberg SA, and Kaplan HS. "Alternating Chemotherapy and Irradiation in the Treatment of Advanced Hodgkin's Disease" Cancer 1979;43:472-481.

Krikorian JG, Portlock CS, Rosenberg SA, and Kaplan HS. "Hodgkin's Disease, Stages I and II Occurring Below the Diaphragm" Cancer 1979;43:1866-1871.

Grant S and Portlock CS. "Current Concepts in Small Cell Carcinoma of the Lung" Connecticut Medicine 1979;43(12):779-782.

Portlock CS, Rosenberg SA, Glatstein E, and Kaplan HS. "Impact of Salvage Treatment on Initial Relapses in Patients with Hodgkin's Disease, Stages I-III" Blood 1978;51:825-833.

Rosenberg SA, Kaplan HS, Glatstein EJ, and Portlock CS. "Combined Modality Therapy of Hodgkin's Disease: A Report on the Stanford Trials" Cancer 1978;42:991-1000.

Porzig KJ, Portlock CS, Robertson A, and Rosenberg SA. "Treatment of Advanced Hodgkin's Disease with B-CAVE: Therapy of Primary MOPP Failures and Relapses" Cancer 1978;42:1705-1710.

Elias L, Portlock CS, and Rosenberg SA. "Combination Chemotherapy of Diffuse Histiocytic Lymphoma with Cyclophosphamide, Adriamycin, Vincristine, and Prednisone (CHOP)" Cancer 1978;42:1705-1710.

Krikorian JG, Portlock CS, and Rosenberg SA. "Treatment of Advanced Hodgkin's Disease with Adriamycin, Bleomycin, Vinblastine, and Imidazole Carboxamide (ABVD) After Failure of MOPP Therapy" Cancer 1978;41:2107-2111.

Portlock CS and Glatstein E. "The Non-Hodgkin's Lymphomas: Current Concepts and Management" Ann Rev Med 1978;29:81.

Portlock CS, Rosenberg SA. "Chemotherapy of the Non-Hodgkin's Lymphoma: The Stanford Experience" Cancer Treat Rep 1977;61:1049-1055.

Langston JW, Ricci DR, Portlock CS. "Nonhypoxemic Hazards of Prolonged Myoclonus" Neurology 1977;27:542-545.

Portlock CS and Rosenberg SA. "Combination Chemotherapy with Cyclophosphamide, Vincristine, and Prednisone in Advanced Non-Hodgkin's Lymphomas" Cancer 1976;37:1275-1282.

Portlock CS, Rosenberg SA, Glatstein E, Kaplan HS. "Treatment of Advanced Non-Hodgkin's Lymphomas with Favorable Histologies: Preliminary Results of a Prospective Trial" Blood 1976;47:747-757.

Jacobs C, Portlock CS, Rosenberg SA. "Prednisone in MOPP Chemotherapy for Hodgkin's Disease" BMJ 1976;2:1469-1471.

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