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Mark R. Green, M.D.
Lung Cancer


Dr. Mark R. Green, a renowned expert in lung cancer research and treatment, is a certified physician in Medical Oncology and Internal Medicine. Dr. Green is currently the Gilbreth Professor of Medicine Clinical Oncology at the Medical University of South Carolina (MUSC), and head of the Respiratory Disease Committee of the Cancer and Leukemia Group B (CALGB) Respiratory Disease Committee. He was a member of the Oncology Drugs Advisory Committee (ODAC). Between 1995 and 1999, Dr. Green served as Chair of the Subspecialty Board on Medical Oncology and as a member of the Board of Directors for the American Board of Internal Medicine.  Dr. Green has also been Chief of Hematology and Oncology, and Director of the Hollings Cancer Center at MUSC. He was also the Tasch Professor of Oncology and Director of the Cancer Center at the University of California San Diego.

Dr. Green was previously the Head of the Division of Hematology and Oncology in the Department of Medicine at the University of California at San Diego (UCSD). He was also the Director at UCSD Cancer Center. Dr. Green was also a Clinical Associate at the Medicine Branch, and Hematology and Supportive Care Branch at National Cancer Institute in Bethesda, MD and was a clinical associate in Biochemistry Section, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland. Dr. Green has authored over 100 scientific publications and has held numerous scientific society and industry advisory boards. Dr. Green completed his medical degree at Harvard Medical School in Boston, Massachusetts. Dr. Green completed his residency training at Beth Israel Hospital and the National Cancer Institute and was a fellow in Oncology in the Division of Oncology, at Stanford University Medical Center in Stanford, CA.

 
 

Scientific Publications:

Rocha Lima CMS, Herndon JE II, Kosty M, Clamon G, Green MR. Therapy choices among older patients with lung carcinoma: An evaluation of two trials of the Cancer and Leukemia Group B. Cancer 94: 181-7, 2002

Rocha Lima CMS, Savarese D, Bruckner H, Dudek A, Eckhardt J, Hainsworth J, Yunas F, Lester E, Miller W, Saville W, Elfring G, Locker P, Compton L, Miller LL, Green MR. Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer. J Clin Oncol 20:1182-91, 2002

Green MR. The evolving role of Gemcitabine and Pemetrexed [AlimtaR] in the management of patients with mesothelioma. Clinical Lung Cancer 3 [suppl 1]: s26-s29, 2002

Blackstock AW, Herndon JE 2nd, Paskett ED, Perry MC, Graziano SL, Muscato JJ, Kosty MP, Akerley WI, Holland J, Fleishman S, Green MR. Outcomes among African-American/non African-American patients with advanced non-small cell lung carcinoma: report from Cancer and Leukemia Group B studies 8931, 8932, 9132, 9532, and 9731. JNCI 94: 284 - 290, 2002

Rocha Lima CMS, Urbanic JJ, Sherman CA, Brescia FJ, Green MR: Docetaxel followed by gemcitabine and irinotecan in solid tumors. Oncology 15:1(suppl 1): 37-45, 2001

Kindler HL, Millard F, Herndon JE, Vogelzang NJ, Suzuki Y, Green MR: Gemcitabine for malignant mesothelioma: A phase II trial by the Cancer and Leukemia Group B. Lung Cancer 31: 311-319, 2001

Niell HB, Perry MC, Clamon G, Crawford J, Miller AA, Herndon J II, Green MR. Carboplatin etoposide and paclitaxel in the treatment of patients with extensive small cell lung cancer. Clinical Lung Cancer 2:204 -09, 2001

Green, MR. The current status of docetaxel for advanced non-small cell lung cancer. Anti- Cancer Drugs 12: S11 - S17, 2001

Breathnach OS, Freidlin B, Conley B, Green MR, Johnson DH, Gandara DR, O'Connell M, Shepherd FA, Johnson BE. Twenty-two years of phase III trials for patients with advanced non-small cell lung cancer: Sobering results. J Clin Oncol 19:1734 - 42, 2001

Loeher PJ, Jiroutek M, Aisner S, Aisner J, Green M, Thomas CR, Livingston R, Johnson DH. Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: An intergroup trial. Cancer 91: 2010-15, 2001

Graziano SL, Tatum A, Herndon JE, Box J, Memoli V, Green MR, Kern JA. Use of neuroendocrine markers, p53, and HER2 to predict response to chemotherapy in patients with stage III non-small cell lung cancer: A Cancer and Leukemia Group B study. Lung Cancer 33: 115-24, 2001

Bahadori HR, Green MR, Catapano CV. Synergistic interaction between topotecan and microtubule-interfering agents. Cancer Chemother Pharmacol 48:188 - 96, 2001

Kosty MP, Herndon JE 2nd, Vogelzang NJ, Kindler HL, Green MR. High-dose doxorubicin, dexrazoxane, and GM-CSF in malignant mesothelioma: a phase II study-Cancer and Leukemia Group B 9631. Lung Cancer 34:289-95, 2001

Perry MC, Ihde DC, Herndon JE 2nd, Grossbard ML, Grethein SJ, Atkins JN, Vokes EE, Green MR: Paclitaxel/ifosfamide or navelbine/ifosfamide chemotherapy for advanced non-small cell lung cancer: CALGB 9532. Lung Cancer 28(1):63-8, 2000

Cappuzzo F, Rocha Lima CM, Sherman CA, Green MR: Advances in treatment of inoperable NSCLC: gemcitabine doublets--a promising alternative. Oncology (Huntingt) 14(7 Suppl 4):7-14, 2000

Green MR, Rocha-lima CM, Sherman CA: Radiation and chemotherapy for patients with stage III non-small cell lung cancer. Semin Rad Oncol 10: 289 - 296, 2000

Shepherd FA, Abratt R, Crino L, Green M, Sandler A, Steward W, Iglesias J, Anglin G: The influence of gemcitabine and cisplatin schedule on response and survival in advanced non-small cell lung cancer. Lung Cancer 30: 117 - 125, 2000

Green MR, Harper M, Safa A, Sherman CA, Mushtaq CM, Bahadori H Brescia FJ, Rocha Lima CMSP: Irinotecan in the Management of Patients with Pancreatic Cancer. Oncology 14:12(suppl 14): 31-33, 2000

Clamon G, Herndon J, Cooper R, Chang AY, Rosenman J, Green MR: Radiosensitization with carboplatin for patients with unresectable stage III non-small cell lung cancer: a phase III trial of the Cancer and Leukemia Group B and the Eastern Cooperative Oncology Group. J Clin Oncol 17(1):4-11, 1999

Tran YK, Bogler O, Gorse KM, Wieland I, Green MR, Newsham IF: A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. Cancer Research 59:35-43, 1999

Herndon JE, Fleishman S, Kornblith Alice, Kosty M, Green MR, Holland J: Is quality of life predictive of the survival of patients with advanced nonsmall cell lung carcinoma? Cancer 85(2):333-340, 1999

Vogelzang NJ, Herndon II JE, Miller A, Strauss G, Clamon G, Stewart FM, Aisner J, Lyss A, Cooper MR, Suzuki Y, Green MR: High-dose paclitaxel plus G-CSF for malignant mesothelioma: CALGB phase II study 9234. Annals of Oncology 10:597-600, 1999

Krasna MJ, Reed CE, Nugent WC, Olak J, Sugarbaker DJ, Green MR, Kohman LJ: Lung Cancer Staging and Treatment in Multidisciplinary Trials: Cancer and Leukemia Group B Cooperative Group Approach. Ann Thorac Surg 68:201-207, 1999

Rocha Lima CM, Leong SS, Sherman CA, Perkel JA, Putman-Hair T, Safa AR, Green MR: Phase I Study of CPT-11 and Gemcitabine in Patients with Solid Tumors. Cancer Therapeutics 2:58-66, 1999

Rocha Lima CM, Eckardt JR, Leong SS, Sherman CA, Perkel JA, Putnam T, Safa AR, Bahadori HR, Green MR: Single-Agent Gemcitabine and Gemcitabine/Irinotecan Combination (IrinoGem) in Non-Small Cell Lung Cancer. Seminars in Onc 26(5) Supp 16:43-50, 1999

Leong SS, Rocha Lima CM, Sherman CA, Green MR: The 1997 international staging system for non-small cell lung cancer: have all the issues been addressed? CHEST 115: 242-248, 1999

Postmus Pieter E, Green Mark R: Overview of mta in the treatment of non-small cell lung cancer. Seminars in Oncology 26(1) Suppl 4: 1999

Kindler HL, Belani CP, Herndon JE, Vogelzang NJ, Suzuki Y, Green MR: Edatrexate (10-Ethyl-Deasa-Aminopterin) (NSC #626715) with or without Leucovorin Rescue for Malignant Mesothelioma. Cancer 86(10):1985-1991, 1999

Vokes EE, Green MR: Current strategies for locoregionally advanced unresectable non-small cell lung cancer. Seminars in Oncology 26(5) Suppl 15:40-43, 1999

Bahadori HR, Rocha Lima CM, Green MR, Safa AR: Synergistic Effect of Gemcitabine and Irinotecan (CPT-11) on Breast and Small Cell Lung Cancer Cell Lines. Anticancer Research 19:1-6, 1999

Clamon G, Herndon J, Akerley W, Green M: Subcutaneous interleukin-2 initial therapy for patients with extensive small cell lung cancer: a phase II trial of Cancer and Leukemia Group B. Lung Cancer 19(1):25-29, 1998

Vokes EE, Green MR: Clinical studies in non-small cell lung cancer: the CALGB experience. Cancer Invest 16(2):72-79, 1998

Ogretmen B, Bahadori HR, McCauley MD, Boylan A, Green MR, Safa AR: Co-ordinated over-expression of the MRP and ?-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines. Int J Cancer 75:757-761, 1998

Rafi I, Boddy AV, Calvete JA, Taylor GA, Newell DR, Bailey NP, Lind MJ, Green M, Hines J, Johnstone A, Clendeninn N, Calvert AH: Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. J Clin Oncol 16(3):1131-1141, 1998.

Ahles TA, Silberfarb PM, Herndon II J, Maurer LH, Kornblith AB, Aisner J, Perry MC, Eaton WL, Zacharski LL, Green MR, Holland JC: Psychologic and Neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin. J Clin Oncol 16:1954-1960, 1998

Perry MC, Herndon III JE, Eaton WL, Green MR: Thoracic radiation therapy added to chemotherapy for small-cell lung cancer.An update of CALGB 8083. J Clin Oncol 16:2466-2467, 1998

Lilenbaum RC, MacManus D, Engstrom C, Green M: Phase I study of paclitaxel and etoposide for metastatic or recurrent malignancies. Am J Clin Oncol (CCT) 21(2):129-134, 1998

Budman DR, Berry DA, Cirrincione CT, Henderson IC, Wood WC, Weiss RB, Ferree CR, Muss HB, Green MR, Norton L, Frei E.III: Dose and Dose Intensity as Determinants of Outcome in the Adjuvant Treatment of Breast Cancer. Journal of the National Cancer Institute 90(16):1205-1211, 1998

Graziano SL, Kern JA, Herndon JE, Tatum A, Brisson ML, Memoli V, Sugarbaker D, Skarin AT, Kreisman H, Green MR: Analysis of neuroendocrine markers, HER2 and CEA before and after chemotherapy in patients with stage IIIA non-small cell lung cancer: A Cancer and Leukemia Group B study. Lung Cancer 21:203-211, 1998

Tran Y, Benbatoul K, Gorse K, Rempel S, Futreal A, Green M, Newsham I: Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast. Oncogene 17:2499-3505, 1998

Miller AA, Rosner GL, Ratain MJ, Hollis DR, Green MR, Schilsky RL: Pharmacology of 21-day oral etoposide given in combination with i.v. cisplatin in patients with extensive-stage small cell lung cancer: a Cancer and Leukemia Group B study (CALGB 9062). Clin Cancer Res 3:719-725, 1997

Vogelzang NJ, Herndon JE, Cirrincione C, Harmon DC, Antman KH, Corson JM, Suzuki Y, Citron ML, Green MR, for the Cancer and Leukemia Group B: Dihydro-5-azacytidine in malignant mesothelioma: a phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer 79(11):2237-2242, 1997

Vokes EE, Leopold KA, Herndon J, Green MR: Investigations of new drugs in combination with cisplatin in stage III non-small cell lung cancer. Sem in Oncol 24(3) Suppl 8:42-45, 1997

Green MR, Barkley JE: Intensity of neoadjuvant therapy in resectable non-small cell lung cancer. Lung Cancer 17 Suppl 1:S111-S119, 1997

Luikart SD, Herndon JE II, Hollis DR, MacDonald M, Maurer LH, Crawford J, Clamon GH, Wright J, Perry MC, Ozer H, Green MR: Phase I trial of etoposide, carboplatin, and GM-CSF in extensive small-cell lung cancer a Cancer and Leukemia Group B study (CALGB 8832). J Clin Oncol 20(1):24-30, 1997

Maurer LH, Herndon JE II, Hollis DR, Aisner J, Carey RW, Skarin AT, Perry MC, Eaton WL, Zacharski LL, Hammond S, Green MR: Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study. J Clin Oncol 15(11):3378-3387, 1997

Niell HB, Miller AA, Clamon GH, Perry MC, Crawford J, Green MR: A phase II study evaluating the efficacy of carboplatin, etoposide, and paclitaxel with granulocyte colony-stimulating pactor in patients with stage IIIB and IV non-small cell lung cancer and extensive small cell lung cancer. Sem in Oncol 24(4 suppl 12):130-134, 1997

Rothenberg ML, Moore MJ, Cripps MC, Andersen JS, Portenoy RK, Burris HA, Green MR, Tarassoff PG, Brown TD, Casper ES, Storniolo AM, Von Hoff DD: A phase II trial of gemcitabine in patients with 5-FU refractory pancreas cancer. Annl of Oncol 7:347-353, 1996

Mitchell EP, Perry MC, Luikart SD, Cirrincione CT, Van Echo DA, Herndon JE II, Maurer LH, Clamon G, Green MR: A phase I/II trial of etoposide and cisplatin in extensive small cell lung cancer: a Cancer and Leukemia Group B study. Lung Cancer 15(2):215-223, 1996

Graziano SL, Valone FH, Herndon JE II, Crawford J, Richards F II, Rege VB, Clamon G, Green MR: A randomized phase II study of ifosfamide/mesna/cisplatin plus G-CSF or etoposide/cisplatin plus G/CSF in advanced non-small cell lung cancer: a Cancer and Leukemia Group B study. Lung Cancer 14:315-329, 1996

Green MR: Gemcitabine safety overview. Seminars in Oncology, Yarbo JW, Bornstein RS, Mastrangelo MJ (eds), 23(4) suppl 10:32-35. WB Saunders, Philadelphia, PA, 1996.

Dillman RO, Herndon J, Seagren SL, Eaton WL Jr, Green MR: Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 8433 trial. JNCI 88(17):1210-1215, 1996

Barkley J, Green MR: Brochioloalveolar carcinoma. J Clin Oncol 14(8):2377-2386, 1996

Barkley J, Green MR: Managing stage III non-small cell lung cancer. J Resp Dis 17(10):858-868, 1996

Bitran JD, Green MR, Perry M, Hollis DR, Herndon JE II: A phase II study of recombinant interferon-gamma following combination chemotherapy for patients with extensive small cell lung cancer. Am J Clin Oncol 18(1):67-70, 1995

Sorscher SM, Green MR, Feramisco JR: Enhanced E-cadherin expression in epidermal growth factor receptor expressing cells. Biochem and Biophy Res Comm 206(2):518-524, 1995

Sorscher SM, Russack V, Cagle M, Feramisco JR, Green MR: Immunolocalization of E-cadherin in human head and neck cancer. Arch Path Lab Med 119:82-84, 1995

Green MR: Multimodality therapy in unresected stage III non-small cell lung cancer: the American Cooperative Groups' experience. Lung Cancer, IASLC 12(suppl 1):S87-S94, 1995

Sorscher SM, Russack V, Graziano S, Cagle M, Feramisco JE, Green MR: Immunohistochemical evaluation of E-cadherin and epidermal growth factor receptor in non-small cell lung cancer. Modern Pathol 8(2):450-455, 1995

Miller AA, Herndon JE II, Hollis DR, Ellerton J, Langleben A, Richards F II, Green MR: Schedule dependency of 21-day oral versus 3-day intravenous etoposide in combination with intravenous cisplatin in extensive-stage small-cell lung cancer: a randomized phase III study of Cancer and Leukemia Group B. J Clin Onc 13(8):1871-1879, 1995

Green MR, Lilenbaum RC: Issues at the cutting edge in stage III non-small-cell lung cancer. Annl of Oncol 6(supple 3):S33-S36, 1995

Alberti W, Anderson G, Bartolucci A, Bell D, Villalba JC, Brodin O, Cardiello C, Cartei F, Cartei G, Cellerino R, Chastang C, Comier Y, Cox JD, Crino L, Crowley J, Dautzenberg B, Depierre A, Dietermann A, Dillman RO, Doi O, Feld R, Figlin R, Ganz PA, Green MR: Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 311:899-909, 1995

Sugarbaker DJ, Herndon J, Kohman LJ, Krasna MJ, Green MR, Cancer and Leukemia Group B Thor Surg Group: Results of Cancer and Leukemia Group B Protocol 8935: a multi institutional phase II study trimodality trial for stage IIIA (N2) non-small cell lung cancer. J Thorac Cardiovasc Surg 109:473-485, 1995

Muscato JJ, Cirrincione C, Clamon G, Perry MC, Omura G, Berkowitz I, Reid T, Herndon JE II, Green MR: Etoposide (VP-16) and cisplatin at maximum tolerated dose in non-small cell lung carcinoma: a Cancer and Leukemia Group B study. Lung Cancer, IASLC 13:285-294, 1995

Aisner J, Albain K, Belani CP, Bunn PA, Choy H, Glantz M, Greco FA, Green MA, Ozols RF, Perez EA: TAXOL (Paclitaxel) for injection concentrate: clinical experience in an outpatient setting. Princeton, Bristol-Myers Squibb Company, 1994

Kosty MP, Fleishman SB, Herndon JE II, Coughlin K, Kornblith AB, Scalzo A, Morris JC, Mortimer J, Green MR: Cisplatin, vinblastine, and hydrazine sulfate in advanced, non-small cell lung cancer: a randomized placebo-controlled, double-blind phase III study of the Cancer and Leukemia Group B. J Clin Onc 12(6):1113-20, June 1994

Green MR, Lilenbaum, RC: Stage IIIA Category of non-small cell lung cancer; a new proposal. JNCI, 86(8):586-8, 1994

Green MR, Multimodal therapy for solid tumors. NEJM, 330(3):206-7, 1994

Casper ES, Green, MR, Kelsen, DP, Heelan RT, Brown TD, Flombaum CD, Trochanowswki B, Tarasoff PG: Phase II trial of gemciatabine (2,2'-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12:29-34, 1994

Clamon G, Herndon J, Eaton W, Rosenman J, Maurer LH, Cooper MR, Green MR: A feasibility study of extended chemotherapy for locally advanced non-small cell lung cancer: a phase II trial of Cancer and Leukemia Group B. Cancer Invest 12(3):273-282, 1994

Green MR, Kosty MP, Muscato J, Graziano S, Dillman RO, Clamon GH, Herndon J: Nonoperative management of non-small cell lung cancer: the current Cancer and Leukemia Group B experience. Semin Onc 21(suppl 6):60-65, 1994

Sorscher SM, Pellitteri P, Robbins KT, Cagle M, Feramisco JR, Green MR, Russack V: Immunolocalization of the retinoblastoma and Myc proteins in human head and neck cancer. Appl Immunohistochem 2(2):81-88, 1994

George SL, Li C, Berry DA, Green MR: Stopping a clinical trial early: frequentist and bayesian approaches applied to a cancer trial in non-small-cell lung cancer. Stat in Med 13:1313-1327, 1994

Lilenbaum RC, Green MR: Multimodality therapy for non-small cell lung cancer. Oncology 8:25-31, 1994

Vogelzang NJ, Weissman LB, Herndon JE II, Antman KH, Cooper MR, Corson JM, Green MR: Trimetrexate in malignant mesothelioma: a Cancer and Leukemia Group B phase II study. J Clin Oncol 12:1436-1442, 1994

Ahles TA, Silberfarb PM, Rundle AC, Holland JC, Kornblith AB, Canellos GP, Green MR, Perry MC: Quality of life in pateints with limited small cell carcinoma of the lung receiving chemotherapy with or without radiation therapy, for Cance and Leukemia Group B. Psychother Psychosom 62:193-199, 1994

Green MR, Ginsberg R, Ardizzoni A, Choi N, Darwish S, Fukuoka M, Giner V, Grunenwald D, Harper P, Kho S, Le Chevalier T, Lewinski T, Payne D, Postmus P, Rochmans P, Rosell R, Roth J, Sculier JP, Sorensen JB: Induction therapy for stage III NSCLC: a consensus report. Lung Cancer 11(suppl 3):S9-S10, 1994

Green MR: The role of induction chemotherapy before radiation therapy in non-operative management of stage III NSCLC. Lung Cancer 11(suppl 3):S55-S65, 1994

Green MR, Cox JD, Ardizzoni A, Arriagada R, Bureau G, Darwish S, Deneffe G, Fukuoka M, Joseph D, Komaki R, Mirimanoff RO, Mornex F, Palazzi M, Pastorino U, Pavy JJ, Postmus PE, Roth J, Rubin P, Saijo N, Saunders M, Stout R, Sutedja TG, Trovo MG: Endpoints for multimodal clinical trials in stage III non-small cell lung cancer (NSCLC): a consensus report. Lung Cancer 11(suppl 3):S11-S13, 1994

Seagren SL, Herndon JE, Baeker JR, Boles M, Chung C, Green MR: Alternating irradiation and chemotherapy in stage IIIA and B non-small cell lung cancer: Report of a Cancer and Leukemia Group B phase II study 8636. Int J Radiation Oncology Biol Phys 29:1085-1088, 1994

Vogel CL, Shemano I, Schoenfelder J, Gams RA, Green MR: Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer. J Clin Oncol 11:345-350, 1993

Parker BA, Santarelli M, Green MR, Anderson JR, Cooper MR, Case D Jr., Barcos M, Peterson BA, Gottlieb AJ: AMOPLACE Treatment of Intermediate-Grade and High-Grade Malignant Lymphoma: A Cancer and Leukemia Group B Study. J Clin Oncol 11:248-254, 1993

Clamon G, Herndon J, Perry MC, Ozer H, Kreisman H, Maher T, Ellerton J, Green MR: Interleukin-2 activity in patients with extensive small-cell lung cancer: A phase II trial of Cancer and Leukemia Group B. J Natl Cancer Inst 85:316-320, 1993

Luikart SD, Goutsou M, Mitchell ED, Van Echo DA, Modeas CR, Propert KJ, O'Donnell J, Difino S, Perry MC, Green MR: Phase I/II trial of etoposide and carboplatin in extensive small cell lung cancer. Am J Clin Oncol 16:127-131, 1993

Graziano SL, Herndon JE II, Richards F II, DiFino S, Modeas C, Duggan DB, Green MR: Phase I trial of ifosfamide, mesna and cisplatin in advanced non-small cell lung cancer: A Cancer and Leukemia Group B study. Cancer 72:62-68, 1993

Lilenbaum RC, Green MR: Novel chemotherapeutic agents in the treatment of non-small cell lung cancer. J Clin Oncol 11:1391-1402, 1993

Green MR: New adjuvant strategies for the management of resectable non-small-cell lung cancer. Chest 103:352S-355S, 1993

Green MR: New directions for chemotherapy in non-small-cell lung cancer. Chest 103:370S-372S, 1993

Chahinian AP, Antman K, Goutsou M, Corson JM, Suzuki Y, Modeas C, Herndon JE II, Aisner J, Ellison RR, Leone L, Vogelzang NJ, Green MR: Randomized phase II trial of cisplatin with mitomycin or doxorubicin for malignant mesothelioma by the Cancer and Leukemia Group B. J Clin Oncol 11:1559-1565, 1993

Kreisman H, Lisbona A, Olson L, Propert KJ, Modeas C, Dillman RO, Seagren SL, Green MR: Effect of radiologic stage III substage on nonsurgical therapy of non-small cell lung cancer. Cancer 72:1588-1596, 1993

Green MR, Kreisman H, Doll DC, Lyss AP, Clamon GH, Goutsou M, Perry MC, Propert KJ: Carboplatin in non-small cell lung cancer: An update on the Cancer and Leukemia B experience. Sem in Oncol 19:(1) Supp 2, 44-49, 1992

Shea TC, Storniolo AM, Mason JR, Newton B, Mullen M, Taetle R, Green MR: A dose escalation study of carboplatin, cyclophosphamide and VP-16 along with autologous bone marrow or peripheral blood stem cell rescue. Sem in Oncol (supp) (in press, 1993)

Aisner J, Goutsou M, Maurer LH, Cooper R, Chahinian P, Carey R, Skarin A, Slawson R, Perry MC, Green MR: Intensive combination chemotherapy, concurrent chest irradiation, and warfarin for the treatment of limited-disease small-cell lung cancer: A Cancer and Leukemia Group B pilot study. J Clin Oncol 10:1230-1236, 1992

Strauss GM, Herndon JE, Sherman DD, Mathisen DJ, Carey RW, Choi NC, Rege VB, Modeas C, Green MR: Neoadjuvant chemotherapy and radiotherapy followed by surgery in stage IIIA non-small-cell carcinoma of the lung: Report of a Cancer and Leukemia Group B Phase II Study. J Clin Oncol 10:1237-1244, 1992

Citron ML, Modeas C, Propert K, Goutsou M, Green MR: Phase II trial of high dose 24-hour continuous infusion 5-Fluorouracil for advanced non-small cell lung cancer: A Cancer and Leukemia Group B study. Cancer Invest 10:215-219, 1992

Lyss AP, Perry MC, Goutsou M, Propert K, Herndon JE, Mason-Coughlin K, Green MR: Intensive etoposide and carboplatin chemotherapy for advanced non-small cell lung cancer: A phase II trial of the Cancer and Leukemia Group B. Am J Clin Oncol 15:399-404, 1992

Canellos GP, Anderson JR, Propert KJ, Nissen N, Cooper MR, Henderson ES, Green MR, Gottlieb A, Peterson BA: Chemotherapy of advanced Hodgkin's disease: A prospective randomized comparison of MOPP, ABVD and MOPP alternating with ABVD. N Eng J Med 327:1478-1484, 1992

Hargis JB, Anderson JR, Propert KJ, Green MR, Van Echo DA, Weiss RB: Predicting genitourinary toxicity in patients receiving cisplatin-based combination chemotherapy: A Cancer and Leukemia Group B study. Cancer Chemother Pharmacol 30:291-296, 1992

Vokes EE, Lyss AP, Herndon JE II, Mason-Coughlin C, Green MR: Intravenous 6-thioguanine or cisplatin, fluorouracil and leucovorin for advanced non-small cell lung cancer: A randomized phase II study of the Cancer and Leukemia Group B. Ann Oncol 3:727-732, 1992

Crawford J, Green MR: The role of colony stimulating factors as an adjunct to lung cancer chemotherapy. Lung Cancer 8:153-158, 1992

Green MR: Sequential chemotherapy and radiotherapy for initial management of stage IIIA and stage IIIB non-small cell lung cancer -induction chemotherapy. Lung Cancer 7:77-84, 1991

Vogelzang NJ, Goutsou M, Corson JM, Suzuki Y, Graziano S, Aisner J, Cooper MR, Coughlin KM, Green MR: Carboplatin in malignant mesothelioma: A phase II study of the Cancer and Leukemia Group B. Cancer Chemother Pharmacol 27:239-242, 1991

Dillman RO, Berry C, Ryan KP, Green MR, Seagren SL: Recent outcomes for patients with carcinoma of the lung. Cancer Invest 9:9-17, 1991

Richards F II, Perry DJ, Goutsou M, Modeas C, Muchmore E, Rege V, Chahinian AP, Hirsh V, Poiesz B, Green MR: Chemotherapy with 5-Fluorouracil (5-FU), cisplatin, and vinblastine for advanced non-small cell lung cancer: A randomized phase II study of the Cancer and Leukemia Group B. Cancer 67:2974-2979, 1991

Ellison RR, Mich R, Cuttner J, Schiffer C, Silver R, Henderson ES, Green MR, Royston I, Davey FR, Glickman AS, Holland JF: The effects of post-induction intensification treatment with cytosine arabinoside and daunorubicine in acute lymphocytic leukemia of adults: A prospective randomized clinical trial by Cancer and Leukemia Group B. J Clin Oncol 9:2002-2015, 1991

Dillman RO, Davis RB, Green MR, Weiss RB, Gottlieb AJ, Caplan S, Kopel S, Preisler H, McIntyre OR, Schiffer C: A comparative study of two different doses of cytarabine for acute myeloid leukemia: A phase III trial of Cancer and Leukemia Group B. Blood 78:2520-2526, 1991

Hamm JT, Tormey DC, Kohler PC, Haller D, Green M, Shemano I: Phase I study of Toremifene in patients with advanced cancer. J Clin Oncol 9:2036-2041 1991

Doll DC, Goutsou M, Graziano S, Ellerton J, Bitran J, Modeas C, Herndon J, Perry M, Green M: Carboplatin and vinblastine in advanced non-small-cell lung cancer: A phase II study. Cancer Chemother Pharmacol 29:71-74, 1991

Green MR: Unresectable stage III non small cell lung cancer: Lessons and directions from clinical trials research (Editorial). J Natl Inst Cancer 83:382-383, 1991

Ringenberg QS, Propert KJ, Muss HB, Weiss RB, Schilsky RL, Modeas C, Perry MC, Norton L, Green MR: Clinical cardiotoxicity of esorubicin (4'-deoxydoxorubicin, DxDx): Prospective studies with serial gated heart scans and reports of selected cases: A Cancer and Leukemia Group B report. Invest New Drugs 8:221-226, 1990

Graziano SL, Lee K, Propert KJ, Tinsley R, Hayes DM, Green M, Comis RL: Phase II trial of etoposide and cisplatin for refractory small cell lung cancer: A Cancer and Leukemia Group B Study. Med Ped Oncol 18:22-26, 1990

Dillman RO, Seagren SL, Propert KJ, Guerra J, Eaton WL, Perry MC, Carey RW, Frei EF III, Green MR: A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small cell lung cancer. New Eng J Med 323:940-945, 1990

Strauss G, Sherman D, Goutsou M, Mathisen D, Carey R, Choi N, Rege V, Modeas C, Propert K, Green M: Neoadjuvant chemotherapy and radiotherapy followed by surgery in stage IIIA non-small cell carcinoma of the lung: A phase II study of the Cancer and Leukemia Group B, in Adjuvant Therapy of Cancer VI. Salmon SE, ed. Philadelphia, W.B. Saunders, 1990, pp 125-132

Kreisman H, Goutsou M, Modeas C, Graziano S, Costanza M, Green M: Cisplatin-carboplatin therapy in extensive non-small cell lung cancer: A Cancer and Leukemia Group B Study. Eur J Cancer 26:1057-1060, 1990

NIH Consensus Development Conference Panel: Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450, 1990

Green MR, Kramar A, Schilsky R, Stoopler M, Zimmer B, Richards F II, Skarin A, Anderson JR: Platinum-based combination chemotherapy in advanced non-small cell lung cancer: A randomized phase II trial of the Cancer and Leukemia Group B. Med Ped Oncol 18:197-202, 1990

Parker BA, Vassos AB, Halpern SE, Miller RA, Hupf H, Amox DG, Sinomi JL, Starr RJ, Green MR, Royston I: Radioimmunotherapy of human B cell lymphoma 90Y-conjugated anti-idiotype monoclonal antibody. Cancer Res (suppl.) 50:1022s-1028s, 1990

Green MR, Kreisman H, Luikart S, Lyss A, Bitran JD, Goutsou M, Propert K: Carboplatin in non-small cell lung cancer: The Cancer and Leukemia Group B experience, in Carboplatin (JM-8): Current Perspectives and Future Directions. Bunn PA, Canetta R, Ozols RF, Rozencweig M, eds. Philadelphia, W.B. Saunders, 1990, pp. 301-306

Spiegelman D, Maurer LH, Ware JH, Perry MC, Chahinian AP, Comis R, Eaton W, Zimmer B, Green MR: Prognostic factors in small cell carcinoma of the lung: An analysis of 1,521 patients. J Clin Onc 7:344-354, 1989

Green MR: Phase III chemotherapy trials in small cell lung cancer. Lung Cancer 5:178-185, 1989

Chahinian AP, Propert KJ, Ware JH, Zimmer B, Perry MC, Hirsh V, Skarin A, Kopel S, Holland JF, Comis RL, Green MR: A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small cell lung cancer by the Cancer and Leukemia Group B. J Clin Onc 7:993-1002, 1989

Bunn PA, Cullen M, Fukuoka M, Green M, Hansen HH, Harper P, Klatersky J, Le Chevalier AT, Sagman U, Splinter T: Chemotherapy in small cell lung cancer, in Management of Small Cell Lung Cancer. Amsterdam, Elsevier, 1989. pp. 9-16

Ringenberg QS, Perry MC, Propert KJ, Modeas C, Hirsh V, Weiss RB, Richards F II, Graziano S, Green M: Phase II trial of 4'-deoxy- doxorubicin (DxDx) in non-small cell lung cancer: A Cancer and Leukemia Group B Trial. Med Ped Oncol 16:27-29, 1988

Choi NC, Propert K, Carey R, Eaton W, Leone LA, Silberfarb P, Green MR: Accelerated radiotherapy followed by chemotherapy for locally recurrent small cell carcinoma of the lung. A phase II study of the Cancer and Leukemia Group B. Int J Rad Onc Biol Phys 13:263-266, 1987

Perry MC, Eaton WL, Propert KJ, Ware JH, Zimmer B, Chahinian AP, Skarin A, Carey RW, Kreisman H, Faulkner C, Comis R, Green MR: Chemotherapy with or without radiation therapy in limited small cell carcinoma of the lung. New Eng J Med 316:912-918, 1987

Luikart SD, Propert KJ, Modeas CR, Green MR, Perry MC: High-dose etoposide therapy for extensive small cell lung cancer: A Cancer and Leukemia Group B study. Cancer Treat Rep 71:533-534, 1987

Kwiatkowski D, Propert K, Carey RW, Choi N, Green MR: A phase II trial of cyclophosphamide, etoposide and cisplatin with combined chest and brain radiotherapy in limited small cell lung cancer: A Cancer and Leukemia Group B Study. J Clin Oncol 5:1874-1879, 1987

Kreisman H, Ginsberg S, Propert K, Richards F, Graziano S, Green MR: Carboplatin or iproplatin in advanced non-small cell lung cancer: A Cancer and Leukemia Group B Study. Cancer Treat Rep 71: 1049-1052, 1987

Cella DF, Orofiamma B, Holland JC, Silberfarb PM, Tross S, Feldstein M, Perry MC, Maurer LH, Comis R, Green MR: Relationship of psychological distress, extent of disease and performance status in patients with lung cancer. Cancer 60:1661-1667, 1987

Carey RW, Anderson J, Green MR, Ellison RR, Nathanson L, Kennedy BJ: Treatment of metastatic malignant melanoma with Vinblastine, Dacarbazine and Cisplatin (VDD). Cancer Treat Rep 70:329-331, 1986

Perry MC, Green MR, Mick R, Schein P: Cisplatin in patients with gastric cancer: A CALGB phase II study. Cancer Treat Rep 70:415-417, 1986

Green MR, Vosika G, Propert KJ, Ware JH, Comis R: Bisantrene in non-small cell lung cancer: A phase II trial of the Cancer and Leukemia Group B. Cancer Treat Rep 70:539-540, 1986

Shilsky RL, Green MR, Anderson J: Cytarabine Cisplatin in patients with advanced cancer. Semin Oncol 12:171-176, 1985

Sobol RE, Dillman RO, Collins H, Griffiths JC, Green MR, Royston I: Applications and limitations of peripheral blood lymphocyte immunoglobulin light chain analysis in the evaluation of non-Hodgkin's lymphoma. Cancer 56:2005-2010, 1985

Young JA, Kossman CR, Green MR: Adenocarcinoma of the fallopian tube: Report of a case with an unusual pattern of metastasis and response to combination chemotherapy. Gyn Onc 17:238-240, 1984

Young JA, Howell SB, Green MR: Pharmacokinetics and toxicity of 5-day continuous infusion of Vinblastine. Cancer Chemother Pharmacol 12:43-45, 1984

Markman M, Howell SB, Lucas WE, Pfeifle CE, Green MR: Combination intraperitoneal chemotherapy with Cisplatin, Cytarabine, and Doxorubicin for refractory ovarian carcinoma and other malignancies principally confined to the peritoneal cavity. J Clin Onc, 2:1321-1326, 1984

Markman M, Howell SB, Green MR: Combination intracavitary chemotherapy for malignant pleural disease. Cancer Drug Delivery 1:333-36, 1984

Young JA, Green MR, Johnson A, Yon JL, Campbell TN, Lucas WE, Kroener J, Koziol JA, Saltzstein S: Alternating combination chemotherapy for stage III and IV ovarian carcinoma. J Clin Onc 2:1317-1320, 1984

Markman M, Green MR: Disease or treatment-related complications in patients with non-Hodgkin's lymphomas, in Your Patient and Cancer, 1984

Amrein PC, Coleman M, Richards F, Poulin RF, Berkowitz I, Kennedy BJ, Green MR, Herschkopf R, Rafla S: Phase II study of AMSA in metastatic renal cell carcinoma: A Cancer and Leukemia Group B study. Cancer Treat Rep 67:1043-1044, 1983

Dillman RO, Beauregard JC, Lea JW, Green MR, Sobol RE, Royston I: Chronic lymphocytic leukemia and other chronic lymphoid proliferations: Surface marker phenotypes and clinical correlations. J Clin Onc 1:190-197, 1983

Carey RW, Comis RL, Anbar D, Kennedy BJ, Capizzi RL, Shulman P, Booth BW, Green MR, Raich PC: Cancer and Leukemia Group B phase II non-small cell lung carcinoma trial: Aziridinylbenzoquinone (AZQ). Cancer Treat Rep 67:95-96, 1983

Green MR, Horton MC, Spaulding M, Silver RT, Berenberg J, Kennedy BJ, Pajak TF, Comis R: Four-drug combination chemotherapy (Methotrexate, Cyclophosphamide, Hexamethylmelamine, and CCNU) for non-small cell bronchogenic carcinoma: A Cancer and Leukemia Group B study. J Clin Onc 1:559-565, 1983

Sobol RE, Dillman RO, Beauregard JC, Yu A, Lea LW, Collins H, Warmsely S, Green MR, Ellison RR, Royston I: Clinical utility of monoclonal antibodies in the phenotyping of acute and chronic lymphocytic leukemia, in Protides of the Biological Fluids. Peters H, ed. New York, Perganon Press, 30:417-422, 1983

Green MR: Primary gastrointestinal lymphomas, in Mediguide to Oncology, Wiernik PH, ed. Lederle, 3:1-5, 1983

Green MR: Epitomes of progress - Internal medicine chemotherapy for disseminated germ cell cancer. West J Med 138:708, 1983

Dillman RO, Orth R, Royston I, Greco C, Green MR: Extracellular paraprotein globules in a patient with monoclonal gammopathy. Arch Pathol Lab Med 106:275-277, 1982

Young JA, Dillman RO, Seagren SL, Taetle R, Rentschler RE, Lea JW, Lehar TJ, Green MR, Stanton W, Mendelsohn J, Royston I: Non-cross-resistant chemotherapy and consolidation radiotherapy for small cell carcinoma of the lung. Cancer Treat Rep 66:1399-1401, 1982

Dillman RO, Beauregard JC, Mendelsohn J, Green MR, Howell SB, Royston I: Phase I trials of thymosin fraction 5 and thymosin dl. J Biol Response Modif 1:35-41, 1982

Howell SB, Pfeifle CL, Wung WE, Olshen RA, Lucas WE, Yon JL, Green MR: Intraperitoneal cisplatin with systemic thiosulfate protection. Ann Intern Med 97:845-851, 1982

Amrein PC, Coleman M, Richards R II, Poulin RF, Bernhardt B, Ginsberg SJ, Green MR, Morrison A, Cortes E, Kiang D, Weinberg V, Wood WC: Phase II study of AMSA in patients with metastatic breast cancer: A Cancer and Leukemia Group B study. Cancer Treat Rep 66:1211-1213, 1982

Yates J, Glidewell O, Wiernik P, Cooper MR, Steinberg D, Dosik H, Levy R, Hoagland C, Henry P, Gottlieb A, Cornell C, Berenberg J, Hutchinson LJ, Raich P, Nissen N, Ellison RR, Frelick R, James GW, Falkson G, Silver RT, Haurani F, Green MR, Henderson E, Leone L, Holland JF: Cytosine arabinoside with Daunorubicin or Adriamycin for therapy of acute myelocytic leukemia: A Cancer and Leukemia Group B study. Blood 60:454-462, 1982

Green MR, Anderson RE: Acute myelocytic leukemia following prolonged Streptozotocin therapy. Cancer 47:1963-65, 1981

Mueh JR, Greco CM, Green MR: Spontaneous regression of metastatic testicular carcinoma in a patient with bilateral sequential testicular tumor. Cancer 45:2908-2912, 1980

Green MR, Dillman RO, Horton MC: Procarbazine, Vincristine, CCNU, and Cyclophosphamide (POCC) in the treatment of metastatic malignant melanoma. Cancer Treat Rep 64:139-142, 1980

Kostinas JE, Leone LA, Cuttner J, Vinciguerra V, Green MR, DeBellis R, Pajak TF: Procarbazine, Vinblastine, and Actinomycin D in stage III and IV melanoma with or without Methanol-extracted residue of bacillus calmette-Guerin. Cancer Treat Rep 63:197-200, 1979

Green MR: Chemotherapy of head and neck cancer. Head Neck Surg 1:75-86, 1978

Bachur N, Riggs C, Green MR, Langone J, Van Vunakis H, Levine L: Human plasma Adriamycin and Daunorubicin by fluorescence and radioimmunoassay. Clin Pharmacol Ther 21:70-77, 1977

Green MR: Pulmonary toxicity of antineoplastic agents. West J Med 127:292-298, 1977

Gutin P, Green MR, Bleyer W, Bauer V, Wiernik P, Walker M: Methotrexate pneumonitis induced by intrathecal methotrexate therapy. A case report with pharmacokinetic data. Cancer 38:1529-1534, 1976

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