Scientific Publications:

Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ; PaTH Study Investigators. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003 Sep 25;349(13):1277-9. ( Read the abstract.)

Eastell R, Barton I, Hannon RA, Chines A, Garnero P, Delmas PD. Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res. 2003 Jun;18(6):1051-6.

Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, Qvist P, Delmas PD, Foged NT, Delaisse JM. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways
of bone collagen degradation. J Bone Miner Res. 2003 May;18(5):859-67.

Ferrari S.L., Ahn-Luong L., Garnero P., Humphries S.E., Greenspan S.L. Two Promoter Polymorphisms Regulating Interleukin-6 Gene Expression Are Associated with Circulating Levels of C-reactive Protein and Markers of Bone Resorption in Postmenopausal Women, J Clin Endocrinol Metab., 88 (1):255-9.

Garnero P., Delmas P.D. An Immunoassay for Type I Collagen Alpha 1 Helicoidal Peptide 620-633, a New Marker of Bone Resorption in Osteoporosis, Bone, 32:20-26.

Garnero P., Ferreras M., Karsdal M.A., Nicamhlaoibh R., Risteli J., Borel O., Qvist P., Delmas P.D., Foged N.T., Delaissé J.M. The Type I Collagen Fragments ICTP and CTX Reveal Distinct Enzymatic Pathways of Bone Collagen Degradation. J Bone Miner Res., 18(5):859-67.

Cloos PA, Fledelius C, Christgau S, Christiansen C, Engsig M, Delmas P, Body JJ, Garnero P. Investigation of bone disease using isomerized and racemized fragments of type I collagen. Calcif Tissue Int 2003 Jan;72(1):8-17

Garnero P, Landewe R, Boers M, Verhoeven A, Van Der Linden S, Christgau S, Van Der Heijde D, Boonen A, Geusens P. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis. Arthritis Rheum. 2002 Nov;46(11):2847-56.

Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, Delmas PD. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum. 2002 Oct;46(10):2613-24.

Garnero P, Jamin C, Benhamou CL, Pelissier C, Roux C. Effects of tibolone and combined 17beta-estradiol and norethisterone acetate on serum C-reactive protein in healthy post-menopausal women: a randomized trial. Hum Reprod. 2002 Oct;17(10):2748-53.

Souberbielle JC, Carlier MC, Bianchi F, Genty V, Jacob N, Kamel S, Kindermans C, Plouvier E, Pressac M, Garnero P. Modalities of prescription of biochemical markers of bone turnover in french hospitals] Ann Biol Clin (Paris). 2002 Sep-Oct;60(5):571-9. French.

Chevrel G, Garnero P, Miossec P. Addition of interleuki 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor alpha soluble receptor more effectively reduces the production of Il6 and macrophage inhibitory protein-3alpha and increases that of ollaenin an in vitro model of rheumatoid synoviocyte activation. Ann Rheum Dis. 2002 Aug;61(8):730-733.

Johnell O, OdenA, De Laet C, Garnero P, Delmas PD, Kanis JA. Biochemical indices of bone turnover and the assessment of fracture probability. Osteoporos Int. 2002 Jul; 13(7):523:526.

Garnero P, Borel O, Sornay-Rendu E, Duboeuf F, Jeffery R, Woo P, Delmas PD. Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the ofely study. Bone. 2002 Jul;31(1):43:50.

Garnero P, Carlier MC, Bianchi F, Gentry V, Jacob N, Kameel S, Kindermans C, Plouvier E, Pressac M, Soubervielle JC. Biochemical markers of bone turnover preanalytical variability and recommendations for use. Iann Biol Clin (Paris). 2002 May-Jun;60(3):339-342. French.

Garnero P, Cloos P, Sornay_Rendu E, Qvist P, Delmas PD. Type I collagen racemization and isomerization and the risk of fracture in postmenopausal women: the OFELY pospective study. J Bone Minerl Res. 2002 May;17(5):826:833.

Chapuy MC, Pamphile R, Paris E, Kempf C, Schlichting M, Arnaud S, Garnero P, Meunier PJ. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002 Mar;13(3):257:264.

Garnero P, Stevens Re, Ayres SA, Phelps KV. Short-term effects of new synthetic conjugated estrogens on biochemical markers of bone turnover. J Clin Pharmacol. 2002 Mar;42(3):290-296.

Szule P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD. Increased bone resorption in moderate smokers with low body weight: the Minos study. J Clin Endocrinol Metab. 2002 Feb;87(2):666-674.

Vesper HW, Demers LM, Eastell R, Garnero P, Kleerekoper M, Robins SP, Srivastava AK, Warnick Gr, Watts NB, Myers GL. Assessment and recommendations on factors contributing to preanalytical variability of urinary pyridinoline and deoxypyridinoline. Clin Chem. 2002 Feb; 48(2)220-235. Review.

Newitt DC, Majumdar S, vn RB, von IG, Harris ST, Genant HK, Chesnut C, Garnero P, MacDonald B. In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical poperties of trabecular bone in the radius. Osteoporos Int. 2002 Jan;13(1):6-17.

Garnero P, Gineyts E, Christgau, S, Finck B, Delmas PD. Association of baseline levels of urinary glucosyl-galactosyl pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. Arthritis Rheum. 2002 Jan;46(1):21-30.

Mougin B, Garnero P, Borel O, Compagnon C, Barbalat V, Marotte H, Miossec P. A routine assay for the direct analysis of HLA-DR-related shared epitope and B27 alleles in chronic inflammatory arthritis. J Immunol Methods. 2001 Oct 1;256(1-2):47-53.

Szulc P, Garnero P, Munoz F., Marchand F., Delmas PD. Cross-sectional evaluation of bone metabolism in men. J Bone Miner Res. 2001 Sep;16(9):1642-50.

Christgau S., Garnero P., Fledelius C., Moniz C., Ensig M., Gineyts E., Rosenquist C., Qvist P. Collagen type II c-telopeptide fragments as an index of cartilage degradation. Bone. 2001 Sep;29(3):209-215

Garnero P. Markers of bone turnover in prostate cancer. Cancer Treat Rev. 2001 Jun;27(3):187-92; discussion 193-6.

Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001 Jun;60(6):619-26.

Garnero P. Biochemical markers of bone remodeling. Ann Biol Clin (Paris) 2001 May-Jun;59(3):298.

Garnero P, Christgau S, Delmas PD. The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone. Bone 2001 May;28(5):461-4.

Garnero P, Christgau S, Delmas PD. Biochemical markers of bone turnover: uses and limitations for the management of postmenopausal osteoporosis. Bone 2001 May; 28(5):461-46.

Garnero P, Souberbielle J.C. Biochemical markers of bone turnover: uses and limitations for the management of postmenopausal osteoporosis. Spectra Biologie 2001 May; 20(117) PAGES??

Lu Y, Fuerst T, Hui S, Genant HK. Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle. Osteoporos Int. 2001;12(6):438-444.

Vignon E, Garnero P, Delmas P, Avouac B, Bettica P, Boers M, Ehrich E, MacKillop N, Rovati L, Serni U, Spector T, Reginster JY. Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers. Osteoarthritis Cartilage 2001 May;9(4):289-93.

Garnero P, Borel O, Delmas PD. Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis. Clin Chem 2001 Apr;47(4):694-702.

Gineyts E, Garnero P, Delmas PD. Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradation. Rheumatology (Oxford) 2001 Mar;40(3):315-23.

Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Delmas PD, Meunier PJ. Effects of a New Selective Estrogen Receptor Modulator (MDL 103,323) on Cancellous and Cortical bone in Ovariectomized Ewes. A Biochemical, Histomorphometric, and Densitometric Study. J Bone Miner Res. 2001 Jan;16(1):89-96.

Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD. Bioavailable Estradiol may be an Important Determinant of Osteoporosis in Men: the MINOS study. J Clin Endocrinol Metab. 2001 Jan;86(1):192-9.

Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries SE, Greenspan SL. A Functional Polymorphic Variant in the Interleukin - 6 Gene Promoter Associated with Lone Bone Resorption in Postmenopausal Women. Arthritis Rheum. 2001 Jan;44(1):196-201.

Delmas PD, Pornel B, Felsenberg D, Stakkestad JA, Radowicki S, Garnero P, Hardy P, Dain MP, Petitier B. Three-year follow-up of the use of transdermal 17beta-estradiol matrix patches for the prevention of bone loss in early postmenopausal women. Am J Obstet Gynecol 2001 Jan;184(2):32-40.

Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Delmas PD, Meunier PJ. Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study. J Bone Miner Res 2001 Jan;16(1):89-96.

Chabaud M, Aarvak T, Garnero P, Natvig JB, Miossec P. Potential contribution of IL-17-producing Th(1)cells to defective repair activity in joint inflammation: partial correction with Th(2)-promoting conditions. Cytokine 2001 Jan 21;13(2):113-8.

Garnero P. Markers of bone turnover for the prediction of fracture risk. Osteoporos Int. 2000;11 Suppl 6:S55-65. Review.

Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J. The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 2000;11 Suppl 6:S2-17.

Garnero P, Bianchi F, Carlier MC, Genty V, Jacob N, Kamel S, Kindermans C, Plouvier E, Pressac M, Souberbielle JC. Biochemical markers of bone remodeling: pre-analytical variations and guidelines for their use. SFBC (Societe Francaise de Biologie Clinique) Work Group. Biochemical markers of bone remodeling. Ann Biol Clin (Paris) 2000 Nov-Dec;58(6):683-704.

P.Garnero, E.Sornay-Rendu, P.D. Delmas. Markers of bone turnover, endogenous hormones, rate of bone loss and fracture risk in the Ofely study. Eds.: R.Eastell, M.Baumann, N R. Hoyle, L.Wieczorek Martin Dunitz London pp 203-210.

R D. Chapurlat, P.Garnero, P. J. Meunier, G. Bréart, P.D. Delmas. Prediction of hip fracture with markers of bone turnover in the EPIDOS study. Eds.: R.Eastell, M.Baumann, N R. Hoyle, L.Wieczorek Martin Dunitz London pp 211-217.

Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas PD. Serum estradiol and sex hormone-binding globulin and the risk of hip fracture in elderly women: the EPIDOS study. J Bone Miner Res. 2000 Sep;15(9):1835-1841.

Garnero P, Sornay-Rendu e, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELLY study. J Bone Miner Res. 2000 Aug 15(8):1526-1536.

Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas PD. Serum type I collagen breakdown product (serum CTX) predicts hip fracture risk in elderly women: the EPIDOS study. Bone. 2000 Aug;27(2):283-286.

Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez F, Moissec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine. 2000 Jul;12(7):1092-1099.

Salamone LM, Fuerst T, Visser M, Kern M, Lang T, Dockrell M, Cauley JA, Nevitt M, Tylavsky F, Lohman TG. Measurement of fat mass using DEXA: a validation study in elderly adults. J Appl Physiol. 2000 Jul;89(1):345-352.

Delmas PD, Hardy P, Garnero P, Dain M. Monitoring individual response to hormone replacement therapy with bone markers. Bone. 2000 Jun;26(6):553-560.

Garnero P, Rousseau JC, Delmas PD. Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium joint diseases. Arthritis Rheum. 2000 May;43(5)953-968.

Delmas PD, Confavreux E, Garnero P, Fardellone P, M de Vernejoul MC, Cormier C, Arce JC. A combination of low doses of 17 beta-estradiol and norethisterone acetate prevents bone loss and normalizes bone turnover in postmenopausal women. Osteoporos Int. 2000;11(2):177-187.

Garnero P, Buchs N, Zekri J, Rizzoli R, Coleman RE, Delmas PD. Markers of bone turnover for the management of patients with bone metastasesx from prostate cancer. Br J Cancer. 2000 Feb;82(4):858:864.

Gineyts E, Cloos PA, Borel O, Brimaud L, Delmas PD, Garnero P. Racemization and isomerization of type I collagen C-telopeptides in human bone and soft tissues: assessment of tissue turnover. Biochem J. 2000 Feb 1;345 Pt 3:481-485.

Duboeuf F, Sornay-Rendu E, Garnero P, Bourgeaud-Lignot A, Delmas PD. Cross-sectional and longitudinal assessment of pre- and postmenopausal bone loss with a portable forearm X-ray device: the Ofely study. Bone. 2000 Feb;26(2):131:135.

Garnero P. Biochemical markers of bone turnover: recent data and avenues for the future. Rev Rhum Engl Ed. 1999 Nov;66(11);538-542. Review.

Garnero P. Biochemical markers of bone turnover: recent data and avenues for the future. Rev Rhum Engl Ed. 1999 Nov;66(11);538-542. Review.

Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD. Treatment of postmenopausal women with osteoporosis or low bone density with raloxifene. Raloxifene Study Group. Osteoporos Int. 1999;10(4):330-336.

Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD. Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study. J Bone Miner Res. 1999 Sep;14(9):1614-1621.

Bauer DC, Sklarin PM, Stone KL, Black DM, Nevitt MC, Ensrud KE, Arnaud CD, Genant HK, Garnero P, Delmas PD, Lawaetz H. Biochemical markers of bone turnover and prediction of hip bone loss in older women: the study of osteoporotic fractures. J Bone Miner Res. 1999 Aug;14(8):1404-1410.

Garnero P, Dargent-Molina P, Hans D, Schott AM, Breart G, Meunier PJ, Delmas PD. Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study. Osteoporos Int. 1998;8(6):563-569

Garnero P, Tsouderos Y, Marton I, Pelissier C, Varin C, Delmas PD. Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like growth factor I in postmenopausal women. J Clin Endocrinol Metab. 1999 Jul;84(7):2390-2397.

Garnero P, Darte C, Delmas PD. A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover. Bone. 1999 Jun;25(6):603:609.

Delmas PD, Pornel B, Felsenberg D, Garnero P, Hardy P, Pilate C, Dain MP. A dose-ranging trial of matrix transdermal 17beta-estradiol for the prevention of bone loss in early postmenopausal women. International Study Group. Bone. 1999 May;24(5):517-523.

Garnero P, Jouvenne P, Buchs N, Delmas PD, Moissec P. Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products. Bone. 1999 Apr;24(4):381-385

Garnero P, Delmas PD. Biochemical markers of bone turnover: clinical usefulness in osteoporosis. Ann Biol Clin (Paris). 1999 Mar-Apr;57(2):137-148. Review. French.

Garnero P, Delmas PD. Variability and response of urinary resorption markers to hormone replacement therapy. J Bone Miner Res. 1999 Mar;14(3):470-472.

Meunier PJ, Vignot E, Garnero P, Confavreux E, Paris E, Liu-Leage S, Sarkar S, Liu T, Wong M, Draper MW. Treatment of postmenopausal women with osteoporosis or low bone density with raloxifene. Raloxifene Study Group. Osteoporos Int. 1999;10(4):330-336.

Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQAeney MS, Foged NT, Delmas PD, Delaisse JM. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem. 1998 Nov 27;273(48):32347-32352.

Garnero P, Delmas PD. Biochemical markers of bone turnover: Applications for osteoporosis. Endocrinol Metab Clin North Am. 1998 Jun;27(2):303-323. Review.

Garnero P, Borel O, Grant SF, Ralston SH, Delmas PD. Collagen Ialpha1 Sp 1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study. J bone Miner Res. 1998 May;13(5):813-817.

Garnero P, Gineyts E, Schaffer AV, Seaman JH, Delmas PD. Measurement of urinary excretion of nonisomerized and beta-isomerized forms of type I collagen breakdown products to monitor the effects of the bisphosphonate zoledronate in Paget's disease. Arthritis Rheum. 1998 Feb;41(2):354-360.

Eccleshall TR, Garnero P, Gross C, Delmas PD, Feldman D. Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: the OFELY study. J Bone Miner Res. 1998 Jan;13(1):31-35.