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Charles G. Peterfy, M.D., Ph.D.
Chief Scientific Officer


Charles G. Peterfy, M.D., Ph.D., is a co-founder of Synarc and currently serves as Chief Scientific Officer. He is a board-certified radiologist with 18 years experience in clinical radiology and fellowship training in musculoskeletal imaging from the University of California San Francisco. At UCSF he served as attending radiologist for seven years and directed arthritis research for the Osteoporosis and Arthritis Research Group. 

Dr. Peterfy received both a Ph.D. in Pharmacology and Therapeutics and his M.D. from McGill University in Montreal, Canada. He is an internationally recognized researcher in the field of musculoskeletal imaging, and has developed many of the imaging techniques and surrogate endpoints that are currently used by pharmaceutical and biotechnology companies in their clinical trials.

Dr. Peterfy has authored more than 150 journal articles and textbook chapters and has lectured internationally on the topic of radiology in clinical practice and clinical research. He is a recipient of the Radiological Society of North America Scholar award. Dr. Peterfy has served on numerous expert panels and international standardization committees to advance medical imaging in clinical trials.

Dr. Charles G. Peterfy can be reached by phone at +1.415.817.8901 and email at Charles.Peterfy@Synarc.com

 
 

Scientific Publications:

Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage. 2004 Mar;12(3):177-90.

Guermazi A, Zaim S, Taouli B, Miaux Y, Peterfy CG, Genant HG. MR findings in knee osteoarthritis. Eur Radiol. 2003 Jun;13(6):1370-86.

McQueen F, Lassere M, Edmonds J, Conaghan P, Peterfy C, Bird P, O'Connor P, Ejbjerg B, Klarlund M, Stewart N, Emery P, Shnier R, Genant H, Ostergaard M. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Summary of OMERACT 6 MR Imaging Module. J Rheumatol. 2003 Jun;30(6):1387-92.

Ostergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, Shnier R, O'Connor P, Klarlund M, Emery P, Genant H, Lassere M, Edmonds J. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol. 2003 Jun;30(6):1385-6.

Conaghan P, Lassere M, Ostergaard M, Peterfy C, McQueen F, O'Connor P, Bird P, Ejbjerg B, Klarlund M, Shnier R, Genant H, Emery P, Edmonds J. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Exercise 4: an international multicenter longitudinal study using the RA-MRI Score. J Rheumatol. 2003 Jun;30(6):1376-9.

Lassere M, McQueen F, Ostergaard M, Conaghan P, Shnier R, Peterfy C, Klarlund M, Bird P, O'Connor P, Stewart N, Emery P, Genant H, Edmonds J. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Exercise 3: an international multicenter reliability study using the RA-MRI Score. J Rheumatol. 2003 Jun;30(6):1366-75.

Peterfy C, Edmonds J, Lassere M, Conaghan P, Ostergaard M, McQueen F, Genant H, Klarlund M, Ejbjerg B, Stewart N, Bird P, Shnier R, O'Connor P, Emery P. OMERACT Rheumatoid Arthritis MRI Studies Module. J Rheumatol. 2003 Jun;30(6):1364-5.

Peterfy CG. New developments in imaging in rheumatoid arthritis. Curr Opin Rheumatol. 2003 May;15(3):288-95.

Li J, Zhong Z, Lidtke R, Kuettner KE, Peterfy C, Aliyeva E, Muehleman C. Radiography of soft tissue of the foot and ankle with diffraction enhanced imaging. J Anat. 2003 May;202(5):463-70.

Sharp JT, Van Der Heijde D, Boers M, Boonen A, Bruynesteyn K, Emery P, Genant HK, Herborn G, Jurik A, Lassere M, McQueen F, OStergaard M, Peterfy C, Rau R, Strand V, Wassenberg S, Weissman B. Repair of Erosions in Rheumatoid Arthritis Does Occur. Results from 2 Studies by the OMERACT Subcommittee on Healing of Erosions. J Rheumatol. 2003 May;30(5):1102-7.

Guermazi A, Miaux Y, Zaim S, Peterfy CG, White D, Genant HK. Metallic artefacts in MR imaging: effects of main field orientation and strength. Clin Radiol. 2003 Apr;58(4):322-8.

Peterfy CG, Dion E, Mizux Y, White D, Jian Y, Lu Y, Zhao S, Zaim S, Sack K, Stevens M, Fye K, Tayefeh F, Majumdar S, Stevens R, Van der Auwera p, Genant HK. Comparison of magnetic resonance imagining and conventional radiography for monitoring structural changes in rheumatoid arthritis. Arthritis Rheum. (submitted)

Peterfy C, Li J, Zaim S, Duryea J, Lynch J, Miaux Y, Yu W, Genant HK. Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol. 2003 Mar;32(3):128-32

Peterfy CG, Maley B. Using imaging biomarkers to demonstrate efficacy: trends and challenges. In: Bloom J (ed.). Biomarkers in Clinical Development. Marcel Dekker, Inc. 2003, Chapter 3, New York.

Peterfy CG. The use of magnetic resonance imaging in rheumatology. In: Isenberg-Renton (eds.). Imaging in Rheumatology. Oxford University Press, London 2003: 48-77

Szechinski J, Grigorian M, Grainger A, Elliott J, Wischer T, Peterfy C, Genant H. Femoral neck and intertrochanteric fractures: radiographic indicators of fracture healing. Orthopedics. 2002 Dec;25(12):1365-8; discussion 1368.

Peterfy CG. Imaging of the disease process. Curr Opin Rheumatol. 2002;14(5):590-6

Brandt KD, Mazzuca SA, Conrozier T, Dacre JE, Peterfy CG, Provvedini D, Ravaud P, Taccoen A, Vignon E. Which is the best radiographic protocol for a clinical trail of a structure modifying drug in patients with knee osteoarthritis? J Rheumatol. 2002;29(6):1308-20

Guermazi A, Miaux Y, Taouli B, Genant HK, Peterfy CG. What is the importance of flow void artifact increase at MR imagaing with gradient-recalled-echo sequences? Radiology. 2002;223(2):585

Guermazi A, Miaux Y, Genant HK, Peterfy CG. Be sure to insert-appropriately and safely-a hookwire! AJR Am J Roentgenol. 2002;178(3):764-5

Peterfy CG. Imaging Cartilage Changes in Osteoarthritis. In: Haskall V, Dieppe P (eds). The Many Faces of Osteoarthritis. Birkhauser, Boston 2002: 329-350

Peterfy CG. The role of MR imaging in clinical research studies. Semin Musculoskelet Radiol. 2001; 5(4):365-378.

Peterfy CG. Magnetic Resonance Imaging of the wrist in rheumatoid arthritis. Semin Musculoskelet Radiol. 2001;5(3):275-287.

Peterfy CG. Magnetic resonance imaging of rheumatoid arthritis: The evolution of clinical applications through clinical trials. Semin Arthritis Rheum. 2001;30(6):375-396.

Conaghan P, Edmonds J, Emery P, Genant H, Gibbon W, Klarlund M, Lassere M, McGonagle D, McQueen F, O'Connor P, Peterfy C, Shnier R, Stewart N, Ostergaard M. Magnetic resonance imaging in rheumatoid arthritis: summary of OMERACT activities, current status, and plans. J Rheumatol. 2001;28(5):1158-1162.

Ostergaard M, Klarlund M, Lassere M, Conaghan P, Peterfy C, McQueen F, O'Connor P, Shnier R, Stewart N, McGonagle D, Emery P, Genant H, Edmonds J. Interreader agreement in the assessment of magnetic resonance images of rheumatoid arthritis wrist and finger joints--an international multicenter study. J Rheumatol. 2001;28(5):1143-1150.

Peterfy CG. Magnetic resonance imaging in rheumatoid arthritis: current status and future directions. J Rheumatol. 2001;28(5):1134-1142.

Gordon CL, Wu C, Peterfy CG, Li J, Duryea J, Klifa C, Genant HK. Automated measurement of radiographic hip joint-space width. Med Phys. 2001;28(2):267-277.

Peterfy CG. Magnetic Resonance Imaging. In: Brandt K, Doherty M, Lohmander S (eds). Osteoarthritis, 2nd Edition. Oxford University Press, New York 2001.

Peterfy CG. Scratching the surface: articular cartilage disorders in the knee. MRI Clin N Am. 2000; 8(2):409-430. Review.

Duryea J, Li J, Peterfy CG, Gordon C, Genant HK. Trainable rule-based algorithm for the measurement of joint space width in digital radiographic images of the knee. Med Phys. 2000; 27(3):580-591.

G. A. Hottya, C. G. Peterfy, M. Uffmann, F. O. Häckl, P. LeHir, J. Rédei, A. U. Gindele, E. Dion, H.K. Genant. Musculoskeletal radiology pictorial review: Dedicated extremity MR imaging of the foot and ankle. Eur Radiol. 2000 10(3): 467-475. Review.

Peterfy CG, Genant HK. Applications of magnetic resonance imaging in arthritis. In: Koopman W J. (ed.) Arthritis and Allied Conditions. A Textbook of Rheumatology, 14 Edition. Williams & Wilkins, Philadelphia; 2000: 118-154

Peterfy CG, Roberts T, Genant HK. Dedicated extremity MR imaging: An emerging technology. Magn Reson Imaging. 1999; 17(2):237-245.

Jiang Y, Peterfy CG, Zhao J, White DL, Lynch JA, Genant. Magnetic Resonance Imaging in Osteoarthritis. In: Reginster JY, Pelletier JP, Martel-Pelletier J, Henrotin Y. (eds.) Osteoarthritis Experimental and Clinical Aspects. Springer. Berlin 1999: 268-295

Miaux Y, Peterfy C, Dion E, Anderson S, Hottya G, White D, Genant HK. Low field MRI of patients with orthopedic hardware. Eur Radiol. 1998; 8(7):1301-1304.

Genant HK, Jiang Y, Peterfy CG, Lu Y, Redei J, Countryman P. Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum. 1998; 41(9):1583-1590.

Miaux Y; Steinbach L; Dion E; Peterfy C. What is going on in the tunnel? [letter] AJR. 1998; 170(3):799-800.

Link T, Majumdar S, Peterfy CG, Daldrup HE, Uffmann M, Dowling C, Steinbach L, Genant HK. High resolution MRI of small joints: impact of spatial resolution on diagnostic performance and SNR. Magn Reson Imaging. 1998; 16(2):147-155.

Heller D, Peterfy C, Genant HK Conceptual framework for cost-effectiveness of imaging tests. Acad Radiol. 1998;5 Suppl 2:S340-343.

Peterfy CG, Genant HK, Mow V, Bigliani L. Evaluating arthritic changes in the shoulder with MRI. In: Steinbach L.S., Tirman PFJ, Peterfy CG, Feller J. (eds.). Shoulder Magnetic Resonance Imaging. Lippencott-Raven, Philadelphia 1998: 221-237

Peterfy CG. Technical considerations. In: Steinbach, L.S., Tirman PFJ, Peterfy CG, Feller, J. (eds.). Shoulder Magnetic Resonance Imaging. Lippencott-Raven, Philadelphia 1998: 37-63.

Peterfy CG, Laorr A. Musculoskeletal Imaging. In: Gamsu G, Patel M. (eds.) Diagnostic Radiology Study Manual. W.B. Saunders, Philadelphia 1998: 203-286

Dieppe P, Peterfy CG, Watt I. Imaging evaluation of osteoarthritis. In: Klippel J, Dieppe P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 8.4.1 - 8.4.10

Peterfy CG, Otte M, Tirman P F J, Medial knee pain in the aging patient. In: Klippel J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 8.12.8 - 8.12.10

Otte M, Peterfy CG. Painful bony lesions in young people. In: Klippel , J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 8.53.1 - 8.53.2

Peterfy CG. Knee pain following renal transplantation. In: Klippel , J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 8.33.6 - 8.33.7

Peterfy CG, Genant HK. Spinal Fractures - Osteoporotic or Neoplastic? In: Klippel , J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 8.43.8 - 8.43.9

Peterfy CG. Tarsal Tunnel Syndrome. In: Klippel , J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 4.18.5 - 4.18.6

Peterfy CG. Imaging techniques. In: Klippel , J, Dieppe, P. (principal eds.). Rheumatology. 2nd Edition. Mosby-Wolfe, London 1998: 2.14.1 - 2.14.18

Peterfy CG. Magnetic Resonance Imaging. In: Brandt, Doherty, Lohmander (eds). Osteoarthritis. Oxford University Press, New York 1998: 473-494

van Dijke CF; Kirk BA; Peterfy CG; Genant HK; Brasch RC; Kapila S. Arthritic temporomandibular joint: correlation of macromolecular contrast-enhanced MR imaging parameters and histopathologic findings. Radiology. 1997; 204(3):825-832.

Stone J, Peterfy CG, Sack K. Bone pain in a transplant patient. Arthritis Rheum 1997 40:1361-1363.

Link TM, Lindner N, Haeussler M, Reimer P, Allkemper T, Jerosch J, Peterfy C, Majumdar S, Peters PE. Artificially produced cartilage lesions in small joints: detection with optimized MRI-sequences. Mang Reson Imaging. 1997; 15(8): 949-956.

Peterfy CG, Howard D. Imaging the patellofemoral joint: current status and future directions. Am J Knee Surg. 1997; 10(2):110-120.

Peterfy CG, Roberts T, Genant HK. Dedicated extremity MRI: An emerging technology. Radiol Clin N Am. 1997; 35(1): 1-20. Review.

Deutsch AL, Mink JH, DeSmet AA, Tuite MJ, Stoller DW, Peterfy CG, Recht MP. The Knee. In: Deutsch A, Mink J. (eds.) MRI of the Musculoskeletal System: A Teaching File. Raven Press 1997: 348-4605.

Peterfy CG, Genant HK. Applications of magnetic resonance imaging in arthritis. In: Koopman W J. (ed.) Arthritis and Allied Conditions. A Textbook of Rheumatology, 13 Edition. Williams & Wilkins, Philadelphia; 1997: 115-152.

CD ROM: Rheumatology. 2nd Edition. Mosby-Wolfe, London 1997: Editor for Imaging

Demsar F, van Dijke CF, Kirk BA, Kapila S, Peterfy CG, Roberts TPL, Shames DM, Mann J, Brasch RC. Mapping abnormal synovial vascular permeability in temporomandibular joint arthritis in the rabbit using MRI. British J Rheum. 1996; 35 Suppl 3: 23-25.

Schnarkowski P, Steinbach LS, Tirman PFJ, Peterfy CG, Genant HK. Magnetic resonance imaging of labral cysts of the hip. Skeletal Radiol. 1996; 25(8):733-737.

Schnarkowski P, Peterfy CG, Johnston JO, Weidner N. Clear cell sarcoma mimicking peripheral nerve sheath tumor. Skeletal Radiol. 1996; 25(2):197-200.

Vahlensieck M, Peterfy CG, Wischer T, Lang P, Schlippert U, Genant HK, Schild H. Indirect MR-arthrography: optimization and clinical applications. Radiology. 1996; 200(1): 249-254.

Peterfy CG. MRI in the assessment of synovium and cartilage. Br J Rheumatol. 1996; 35 Suppl 3:3-5. Review.

Peterfy CG. MR imaging. Baillieres Clinical Rheumatology. 1996;10(4):635-678. Review.

Peterfy CP, Genant HK. Emerging applications of MRI in the evaluation of articular cartilage. Radiol Clin N Am. 1996; 34(2): 195-213.ix. Review.

Lang P, Vahlensieck M, Johnston JO, Roberts T, Gooding C, Honda G, Rosenau W, Peterfy CG, Genant HK. Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates. Radiology. 1995; 197(3):831-839.

Lang P, Suh KJ, Grampp S, Steinbach L, Steiner E, Peterfy C, Tirman P, Schwickert H, Rosenau W, Genant HK. CT and MR imaging of elastofibroma: a rare, benign soft-tissue tumor. Radiology. 1995; 35(9):611-615.

Lang P, Grampp S, Vahlensieck M, Johnston JO, Honda G, Roseneau W, Peterfy CG, Higgins C, Genant HK, Gooding C. Primary bone tumors - value of mr angiography for preoperative planning and monitoring response to chemotherapy. AJR. 1995; 165(1):135-142.

Gramas DA, Antounian FS, Peterfy CG, Lane NE. The diagnostic accuracy of needle arthroscopy, standard arthroscopy, physical examination and magnetic resonance imaging in knee pain: a pilot study. J Clin Rheum. 1995; 1:26-34.

Schnarkowski P, Rédei J, Peterfy CG, Weidenmaier W, Mutschler W, Arand M, Reiser MF. Tibial shaft fractures: assessment of fracture healing with computed tomography. J Comput Assist Tomogr. 1995; 19(5):777-781.

Garvin G, Peterfy CG. Soft tissue cocidiomycosis on MRI. J Comput Assist Tomogr 1995; 19(4):612-614.

Laorr A, Peterfy CG, Tirman PF, Rabassa AE. Lipoma arborescens of the shoulder: magnetic resonance imaging findings. Can Assoc Radiol J. 1995; 46(4):311-313.

Peterfy CG. Fast spin echo techniques are being widely used. What is the role of fast spin sequences compared with spin echo sequences in shoulder and knee MR imaging examinations. AJR.. 1995; 165(3):734-735.

Peterfy CG, van Dijke CF, Lu Y, Nguyen A, Connick T, Kneeland B, Tirman PFJ, Lang P, Dent S, Genant HK. Quantification of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of 3D MR imaging. AJR. 1995; 165(2): 371-375.

Peterfy CG, Steiner E, Genant HK. MRI of vertebral fracture. In: Genant HK, Jergas, M, van Kuijk C. (eds.). Vertebral Fracture in Osteoporosis. Radiology Research and Education Foundation, San Francisco; 1995:105-127.

Dieppe P, Altman RD, Buckwalter JA, Felson DT, Hascall V, Lohmander LS, Peterfy CG, Roos H, Kuettner KE. Standardization of methods used to assess the progression of osteoarthritis of the hip or knee joints. In: Kuettner KE, Goldberg VM. (eds.) Osteoarthritic Disorders. American Association of Orthopaedic Surgeons; Rosemont; 1995: 481-496

Tirman PFJ, Bost FW, Steinbach LS, Mall JC, Peterfy CG, Sampson TG, Sheehan WE, Forbes RJ, Genant HK. MR arthrographic depiction of tears of the rotator cuff: benefit of abduction and external rotation of the arm. Radiology. 1994; 192(3): 851-856.

Tirman PFJ, Bost FW, Garvin GJ, Peterfy CG, Mall JC , Steinbach LS, Feller JF, Crues III JV. Posterosuperior glenoid impingement: MRI and MR arthrographic findings with arthroscopic correlation. Radiology. 1994; 193(2):431-436.

Tirman PFJ, Feller JF, Janzen DL, Peterfy CG, Bergman AG. Association of glenoid labral cysts with labral tears and glenohumoral instability: radiological findings and clinical significance. Radiology. 1994; 190(3):653-658.

Linker C, Peterfy C, Helms C. Intraosseous pneumatocyst of the clavicle: case report. Skeletal Radiol. 1994; 23:315-316.

Chan WP, Peterfy CG, Fritz RC, Genant HK. MR diagnosis of complete tears of the anterior cruciate ligament of the knee - importance of anterior subluxation of the tibia. AJR. 1994; 162(2):355-360.

Janzen DL, Peterfy CG, Tirman PFJ, Genant HK. Cystic lesions around the knee joint: MR imaging findings. AJR. 1994; 163(1):155-161.

Peterfy C, Linares, R, Steinbach, L. Recent advances in magnetic resonance imaging of the musculoskeletal system. Radiol Clin N Am. 1994; 32(2):291-311.

Peterfy CG, van Dijke CF, Janzen DL, Namba R, Majumdar S, Glüer C, Lang P, Genant HK. Quantification of articular cartilage by pulsed saturation transfer subtraction and fat-suppressed MRI: optimization and validation. Radiology. 1994; 192(2) 485-491.

Peterfy CG, Janzen DL, Tirman PFJ, van Dijke CF, Pollack M, Genant HK. Magic-angle phenomenon: a cause of increased signal in the normal lateral meniscus on short-TE MR images of the knee. AJR.. 1994; 163(1):149-154.

Peterfy C, Majumdar S, Lang P, van Dijke CF, Sack K, Genant HK. MR imaging of the arthritic knee: improved discrimination of cartilage, synovium and effusion with pulsed saturation transfer and fat-suppressed, T1-weighted sequences. Radiology. 1994; 191(2):413-419.

Peterfy CG, Staewen S, Padmanabahn M, Genant HK. Imaging the hip with multicoil phased arrays. In MRI Clinical Symposia. Ciba Geigy, 1994.

Lang P, Fritz R, Majumdar S, Vahlensieck M, Peterfy C, Genant HK. Hematopoietic bone marrow in the adult knee: spin echo and opposed-phase gradient echo MR imaging. Skeletal Radiol. 1993; 22(2):95-103.

Choo I, Peterfy C. Borderlands of Normal and Early Findings in Skeletal Radiology [Book Review]. AJR.. 1993; 161:848.

Ho V, Peterfy C, Helms C. Tarsal tunnel syndrome caused by strain of an anomolous muscle: an MRI-specific diagnosis. J Comput Assist Tomogr. 1993; 71(5):822-823.

Peterfy C, Genant HK. Meeting News: American Roentgen Ray Society 93rd Annual Meeting, April 93: Session 26, Shoulder. AJR. 1993; 161:657.

Chan W, Peterfy CG, Erickson SJ, Helms C. The ankle and foot. In: Chan WP, Lang P, Genant HK. (eds.) Musculoskeletal Magnetic Resonance Imaging: Perspectives for Radiologists, Orthopedists and Rheumatologists. W.B. Saunders, Philadelphia; 1993: 351-385

Seguin N, Peterfy C, Dusault, R. General case of the day: cystic rheumatoid arthritis. RadioGraphics. 1992; 12(1): 203-206.

Peterfy C, Rosenthall L. Telangiectatic focal nodular hyperplasia presenting with normal radionuclide studies: Case report. J Nuclear Med. 1990; 31(12):2037-2039.

Peterfy C, Atri M. Intrahepatic abscess: a rare complication of ventriculo-peritoneal shunts. AJR. 1990; 155(4):894-895.

Peterfy CG. Vitamin D and Parotid Gland Secretion in the Rat. Ph.D. Thesis. McGill University, Montreal, Canada, 1989.

Peterfy C, Tenenhouse A, Yu E. Vitamin D and parotid gland function in the rat. J Physiol. 1988; 398:1-13.

Glijer B, Peterfy C, Tenenhouse A. The effect of Vitamin D deficiency on secretion of saliva by the rat parotid gland in vivo. J Physiol. 1985; 363:323-334.

Peterfy C, Tenenhouse A. Vitamin-D receptors in isolated rat parotid gland acinar cells. Biochim Biophys Acta. 1982; 721(2):158-163.

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