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Scientific Publications:
Black DM, Greenspan SL, Ensrud KE, Palermo L,
McGowan JA, Lang TF,
Garnero P, Bouxsein ML, Bilezikian JP, Rosen
CJ; PaTH Study Investigators. The effects of
parathyroid hormone and alendronate alone or in
combination in postmenopausal osteoporosis. N Engl J
Med. 2003 Sep 25;349(13):1277-9. ( Read
the abstract.)
Eastell R, Barton I, Hannon RA, Chines A, Garnero
P, Delmas PD. Relationship of early changes in bone
resorption to the reduction in fracture risk with
risedronate. J Bone Miner Res. 2003 Jun;18(6):1051-6.
Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R,
Risteli J, Borel O, Qvist P, Delmas PD, Foged NT,
Delaisse JM. The type I collagen fragments ICTP and
CTX reveal distinct enzymatic pathways
of bone collagen degradation. J Bone Miner Res. 2003
May;18(5):859-67.
Ferrari S.L., Ahn-Luong L., Garnero P., Humphries S.E., Greenspan S.L. Two
Promoter Polymorphisms Regulating Interleukin-6 Gene Expression Are Associated
with Circulating Levels of C-reactive Protein and Markers of Bone Resorption in
Postmenopausal Women, J Clin Endocrinol Metab., 88 (1):255-9.
Garnero P., Delmas P.D. An Immunoassay for Type I Collagen Alpha 1 Helicoidal
Peptide 620-633, a New Marker of Bone Resorption in Osteoporosis, Bone, 32:20-26.
Garnero P., Ferreras M., Karsdal M.A., Nicamhlaoibh R., Risteli J., Borel O.,
Qvist P., Delmas P.D., Foged N.T., Delaissé J.M. The Type I Collagen Fragments
ICTP and CTX Reveal Distinct Enzymatic Pathways of Bone Collagen Degradation.
J Bone Miner Res., 18(5):859-67.
Cloos PA, Fledelius C, Christgau S, Christiansen C, Engsig M, Delmas P, Body
JJ, Garnero P. Investigation of bone disease using isomerized and racemized fragments
of type I collagen. Calcif Tissue Int 2003 Jan;72(1):8-17
Garnero P, Landewe R, Boers M, Verhoeven A, Van Der
Linden S, Christgau S, Van Der Heijde D, Boonen A,
Geusens P. Association of baseline levels of markers
of bone and cartilage degradation with long-term progression
of joint damage in patients with early rheumatoid
arthritis. Arthritis Rheum. 2002 Nov;46(11):2847-56.
Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell
LJ, Dougados M, Delmas PD. Uncoupling of type II collagen
synthesis and degradation predicts progression of
joint damage in patients with knee osteoarthritis.
Arthritis Rheum. 2002 Oct;46(10):2613-24.
Garnero P, Jamin C, Benhamou CL, Pelissier C, Roux
C. Effects of tibolone and combined 17beta-estradiol
and norethisterone acetate on serum C-reactive protein
in healthy post-menopausal women: a randomized trial.
Hum Reprod. 2002 Oct;17(10):2748-53.
Souberbielle JC, Carlier MC, Bianchi F, Genty V,
Jacob N, Kamel S, Kindermans C, Plouvier E, Pressac
M, Garnero P. Modalities of prescription of biochemical
markers of bone turnover in french hospitals] Ann
Biol Clin (Paris). 2002 Sep-Oct;60(5):571-9. French.
Chevrel G, Garnero P, Miossec P. Addition of interleuki
1 (IL1) and IL17 soluble receptors to a tumour necrosis
factor alpha soluble receptor more effectively reduces
the production of Il6 and macrophage inhibitory protein-3alpha
and increases that of ollaenin an in vitro model of
rheumatoid synoviocyte activation. Ann Rheum Dis.
2002 Aug;61(8):730-733.
Johnell O, OdenA, De Laet C, Garnero P, Delmas PD,
Kanis JA. Biochemical indices of bone turnover and
the assessment of fracture probability. Osteoporos
Int. 2002 Jul; 13(7):523:526.
Garnero P, Borel O, Sornay-Rendu E, Duboeuf F, Jeffery
R, Woo P, Delmas PD. Association between a functional
interleukin-6 gene polymorphism and peak bone mineral
density and postmenopausal bone loss in women: the
ofely study. Bone. 2002 Jul;31(1):43:50.
Garnero P, Carlier MC, Bianchi F, Gentry V, Jacob
N, Kameel S, Kindermans C, Plouvier E, Pressac M,
Soubervielle JC. Biochemical markers of bone turnover
preanalytical variability and recommendations for
use. Iann Biol Clin (Paris). 2002 May-Jun;60(3):339-342.
French.
Garnero P, Cloos P, Sornay_Rendu E, Qvist P, Delmas
PD. Type I collagen racemization and isomerization
and the risk of fracture in postmenopausal women:
the OFELY pospective study. J Bone Minerl Res. 2002
May;17(5):826:833.
Chapuy MC, Pamphile R, Paris E, Kempf C, Schlichting
M, Arnaud S, Garnero P, Meunier PJ. Combined calcium
and vitamin D3 supplementation in elderly women: confirmation
of reversal of secondary hyperparathyroidism and hip
fracture risk: the Decalyos II study. Osteoporos Int.
2002 Mar;13(3):257:264.
Garnero P, Stevens Re, Ayres SA, Phelps KV. Short-term
effects of new synthetic conjugated estrogens on biochemical
markers of bone turnover. J Clin Pharmacol. 2002 Mar;42(3):290-296.
Szule P, Garnero P, Claustrat B, Marchand F, Duboeuf
F, Delmas PD. Increased bone resorption in moderate
smokers with low body weight: the Minos study. J Clin
Endocrinol Metab. 2002 Feb;87(2):666-674.
Vesper HW, Demers LM, Eastell R, Garnero P, Kleerekoper
M, Robins SP, Srivastava AK, Warnick Gr, Watts NB,
Myers GL. Assessment and recommendations on factors
contributing to preanalytical variability of urinary
pyridinoline and deoxypyridinoline. Clin Chem. 2002
Feb; 48(2)220-235. Review.
Newitt DC, Majumdar S, vn RB, von IG, Harris ST,
Genant HK, Chesnut C, Garnero P, MacDonald B. In vivo
assessment of architecture and micro-finite element
analysis derived indices of mechanical poperties of
trabecular bone in the radius. Osteoporos Int. 2002
Jan;13(1):6-17.
Garnero P, Gineyts E, Christgau, S, Finck B, Delmas
PD. Association of baseline levels of urinary glucosyl-galactosyl
pyridinoline and type II collagen C-telopeptide with
progression of joint destruction in patients with
early rheumatoid arthritis. Arthritis Rheum. 2002
Jan;46(1):21-30.
Mougin B, Garnero P, Borel O, Compagnon C, Barbalat
V, Marotte H, Miossec P. A routine assay for the direct
analysis of HLA-DR-related shared epitope and B27
alleles in chronic inflammatory arthritis. J Immunol
Methods. 2001 Oct 1;256(1-2):47-53.
Szulc P, Garnero P, Munoz F., Marchand F., Delmas
PD. Cross-sectional evaluation of bone metabolism
in men. J Bone Miner Res. 2001 Sep;16(9):1642-50.
Christgau S., Garnero P., Fledelius C., Moniz C.,
Ensig M., Gineyts E., Rosenquist C., Qvist P. Collagen
type II c-telopeptide fragments as an index of cartilage
degradation. Bone. 2001 Sep;29(3):209-215
Garnero P. Markers of bone turnover in prostate cancer.
Cancer Treat Rev. 2001 Jun;27(3):187-92; discussion
193-6.
Garnero P, Piperno M, Gineyts E, Christgau S, Delmas
PD, Vignon E. Cross sectional evaluation of biochemical
markers of bone, cartilage, and synovial tissue metabolism
in patients with knee osteoarthritis: relations with
disease activity and joint damage. Ann Rheum Dis 2001
Jun;60(6):619-26.
Garnero P. Biochemical markers of bone remodeling.
Ann Biol Clin (Paris) 2001 May-Jun;59(3):298.
Garnero P, Christgau S, Delmas PD. The bisphosphonate
zoledronate decreases type II collagen breakdown in
patients with Paget's disease of bone. Bone 2001 May;28(5):461-4.
Garnero P, Christgau S, Delmas PD. Biochemical markers
of bone turnover: uses and limitations for the management
of postmenopausal osteoporosis. Bone 2001 May; 28(5):461-46.
Garnero P, Souberbielle J.C. Biochemical markers
of bone turnover: uses and limitations for the management
of postmenopausal osteoporosis. Spectra Biologie 2001
May; 20(117) PAGES??
Lu Y, Fuerst T, Hui S, Genant HK. Standardization
of bone mineral density at femoral neck, trochanter
and Ward's triangle. Osteoporos Int. 2001;12(6):438-444.
Vignon E, Garnero P, Delmas P, Avouac B, Bettica
P, Boers M, Ehrich E, MacKillop N, Rovati L, Serni
U, Spector T, Reginster JY. Recommendations for the
registration of drugs used in the treatment of osteoarthritis:
an update on biochemical markers. Osteoarthritis Cartilage
2001 May;9(4):289-93.
Garnero P, Borel O, Delmas PD. Evaluation of a fully
automated serum assay for C-terminal cross-linking
telopeptide of type I collagen in osteoporosis. Clin
Chem 2001 Apr;47(4):694-702.
Gineyts E, Garnero P, Delmas PD. Urinary excretion
of glucosyl-galactosyl pyridinoline: a specific biochemical
marker of synovium degradation. Rheumatology (Oxford)
2001 Mar;40(3):315-23.
Chavassieux P, Garnero P, Duboeuf F, Vergnaud P,
Brunner-Ferber F, Delmas PD, Meunier PJ. Effects of
a New Selective Estrogen Receptor Modulator (MDL 103,323)
on Cancellous and Cortical bone in Ovariectomized
Ewes. A Biochemical, Histomorphometric, and Densitometric
Study. J Bone Miner Res. 2001 Jan;16(1):89-96.
Szulc P, Munoz F, Claustrat B, Garnero P, Marchand
F, Duboeuf F, Delmas PD. Bioavailable Estradiol may
be an Important Determinant of Osteoporosis in Men:
the MINOS study. J Clin Endocrinol Metab. 2001 Jan;86(1):192-9.
Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries
SE, Greenspan SL. A Functional Polymorphic Variant
in the Interleukin - 6 Gene Promoter Associated with
Lone Bone Resorption in Postmenopausal Women. Arthritis
Rheum. 2001 Jan;44(1):196-201.
Delmas PD, Pornel B, Felsenberg D, Stakkestad JA,
Radowicki S, Garnero P, Hardy P, Dain MP, Petitier
B. Three-year follow-up of the use of transdermal
17beta-estradiol matrix patches for the prevention
of bone loss in early postmenopausal women. Am J Obstet
Gynecol 2001 Jan;184(2):32-40.
Chavassieux P, Garnero P, Duboeuf F, Vergnaud P,
Brunner-Ferber F, Delmas PD, Meunier PJ. Effects of
a new selective estrogen receptor modulator (MDL 103,323)
on cancellous and cortical bone in ovariectomized
ewes: a biochemical, histomorphometric, and densitometric
study. J Bone Miner Res 2001 Jan;16(1):89-96.
Chabaud M, Aarvak T, Garnero P, Natvig JB, Miossec
P. Potential contribution of IL-17-producing Th(1)cells
to defective repair activity in joint inflammation:
partial correction with Th(2)-promoting conditions.
Cytokine 2001 Jan 21;13(2):113-8.
Garnero P. Markers of bone turnover for the prediction
of fracture risk. Osteoporos Int. 2000;11 Suppl 6:S55-65.
Review.
Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan
J. The use of biochemical markers of bone turnover
in osteoporosis. Committee of Scientific Advisors
of the International Osteoporosis Foundation. Osteoporos
Int 2000;11 Suppl 6:S2-17.
Garnero P, Bianchi F, Carlier MC, Genty V, Jacob
N, Kamel S, Kindermans C, Plouvier E, Pressac M, Souberbielle
JC. Biochemical markers of bone remodeling: pre-analytical
variations and guidelines for their use. SFBC (Societe
Francaise de Biologie Clinique) Work Group. Biochemical
markers of bone remodeling. Ann Biol Clin (Paris)
2000 Nov-Dec;58(6):683-704.
P.Garnero, E.Sornay-Rendu, P.D. Delmas. Markers of
bone turnover, endogenous hormones, rate of bone loss
and fracture risk in the Ofely study. Eds.: R.Eastell,
M.Baumann, N R. Hoyle, L.Wieczorek Martin Dunitz London
pp 203-210.
R D. Chapurlat, P.Garnero, P. J. Meunier, G. Bréart,
P.D. Delmas. Prediction of hip fracture with markers
of bone turnover in the EPIDOS study. Eds.: R.Eastell,
M.Baumann, N R. Hoyle, L.Wieczorek Martin Dunitz London
pp 211-217.
Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas
PD. Serum estradiol and sex hormone-binding globulin
and the risk of hip fracture in elderly women: the
EPIDOS study. J Bone Miner Res. 2000 Sep;15(9):1835-1841.
Garnero P, Sornay-Rendu e, Claustrat B, Delmas PD.
Biochemical markers of bone turnover, endogenous hormones
and the risk of fractures in postmenopausal women:
the OFELLY study. J Bone Miner Res. 2000 Aug 15(8):1526-1536.
Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas
PD. Serum type I collagen breakdown product (serum
CTX) predicts hip fracture risk in elderly women:
the EPIDOS study. Bone. 2000 Aug;27(2):283-286.
Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez
F, Moissec P. Contribution of interleukin 17 to synovium
matrix destruction in rheumatoid arthritis. Cytokine.
2000 Jul;12(7):1092-1099.
Salamone LM, Fuerst T, Visser M, Kern M, Lang T,
Dockrell M, Cauley JA, Nevitt M, Tylavsky F, Lohman
TG. Measurement of fat mass using DEXA: a validation
study in elderly adults. J Appl Physiol. 2000 Jul;89(1):345-352.
Delmas PD, Hardy P, Garnero P, Dain M. Monitoring
individual response to hormone replacement therapy
with bone markers. Bone. 2000 Jun;26(6):553-560.
Garnero P, Rousseau JC, Delmas PD. Molecular basis
and clinical use of biochemical markers of bone, cartilage,
and synovium joint diseases. Arthritis Rheum. 2000
May;43(5)953-968.
Delmas PD, Confavreux E, Garnero P, Fardellone P,
M de Vernejoul MC, Cormier C, Arce JC. A combination
of low doses of 17 beta-estradiol and norethisterone
acetate prevents bone loss and normalizes bone turnover
in postmenopausal women. Osteoporos Int. 2000;11(2):177-187.
Garnero P, Buchs N, Zekri J, Rizzoli R, Coleman RE,
Delmas PD. Markers of bone turnover for the management
of patients with bone metastasesx from prostate cancer.
Br J Cancer. 2000 Feb;82(4):858:864.
Gineyts E, Cloos PA, Borel O, Brimaud L, Delmas PD,
Garnero P. Racemization and isomerization of type
I collagen C-telopeptides in human bone and soft tissues:
assessment of tissue turnover. Biochem J. 2000 Feb
1;345 Pt 3:481-485.
Duboeuf F, Sornay-Rendu E, Garnero P, Bourgeaud-Lignot
A, Delmas PD. Cross-sectional and longitudinal assessment
of pre- and postmenopausal bone loss with a portable
forearm X-ray device: the Ofely study. Bone. 2000
Feb;26(2):131:135.
Garnero P. Biochemical markers of bone turnover:
recent data and avenues for the future. Rev Rhum Engl
Ed. 1999 Nov;66(11);538-542. Review.
Garnero P. Biochemical markers of bone turnover:
recent data and avenues for the future. Rev Rhum Engl
Ed. 1999 Nov;66(11);538-542. Review.
Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD.
Treatment of postmenopausal women with osteoporosis
or low bone density with raloxifene. Raloxifene Study
Group. Osteoporos Int. 1999;10(4):330-336.
Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD.
Markers of bone turnover predict postmenopausal forearm
bone loss over 4 years: the OFELY study. J Bone Miner
Res. 1999 Sep;14(9):1614-1621.
Bauer DC, Sklarin PM, Stone KL, Black DM, Nevitt
MC, Ensrud KE, Arnaud CD, Genant HK, Garnero P, Delmas
PD, Lawaetz H. Biochemical markers of bone turnover
and prediction of hip bone loss in older women: the
study of osteoporotic fractures. J Bone Miner Res.
1999 Aug;14(8):1404-1410.
Garnero P, Dargent-Molina P, Hans D, Schott AM, Breart
G, Meunier PJ, Delmas PD. Do markers of bone resorption
add to bone mineral density and ultrasonographic heel
measurement for the prediction of hip fracture in
elderly women? The EPIDOS prospective study. Osteoporos
Int. 1998;8(6):563-569
Garnero P, Tsouderos Y, Marton I, Pelissier C, Varin
C, Delmas PD. Effects of intranasal 17beta-estradiol
on bone turnover and serum insulin-like growth factor
I in postmenopausal women. J Clin Endocrinol Metab.
1999 Jul;84(7):2390-2397.
Garnero P, Darte C, Delmas PD. A model to monitor
the efficacy of alendronate treatment in women with
osteoporosis using a biochemical marker of bone turnover.
Bone. 1999 Jun;25(6):603:609.
Delmas PD, Pornel B, Felsenberg D, Garnero P, Hardy
P, Pilate C, Dain MP. A dose-ranging trial of matrix
transdermal 17beta-estradiol for the prevention of
bone loss in early postmenopausal women. International
Study Group. Bone. 1999 May;24(5):517-523.
Garnero P, Jouvenne P, Buchs N, Delmas PD, Moissec
P. Uncoupling of bone metabolism in rheumatoid arthritis
patients with or without joint destruction: assessment
with serum type I collagen breakdown products. Bone.
1999 Apr;24(4):381-385
Garnero P, Delmas PD. Biochemical markers of bone
turnover: clinical usefulness in osteoporosis. Ann
Biol Clin (Paris). 1999 Mar-Apr;57(2):137-148. Review.
French.
Garnero P, Delmas PD. Variability and response of
urinary resorption markers to hormone replacement
therapy. J Bone Miner Res. 1999 Mar;14(3):470-472.
Meunier PJ, Vignot E, Garnero P, Confavreux E, Paris
E, Liu-Leage S, Sarkar S, Liu T, Wong M, Draper MW.
Treatment of postmenopausal women with osteoporosis
or low bone density with raloxifene. Raloxifene Study
Group. Osteoporos Int. 1999;10(4):330-336.
Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake
FH, McQAeney MS, Foged NT, Delmas PD, Delaisse JM.
The collagenolytic activity of cathepsin K is unique
among mammalian proteinases. J Biol Chem. 1998 Nov
27;273(48):32347-32352.
Garnero P, Delmas PD. Biochemical markers of bone
turnover: Applications for osteoporosis. Endocrinol
Metab Clin North Am. 1998 Jun;27(2):303-323. Review.
Garnero P, Borel O, Grant SF, Ralston SH, Delmas
PD. Collagen Ialpha1 Sp 1 polymorphism, bone mass,
and bone turnover in healthy French premenopausal
women: the OFELY study. J bone Miner Res. 1998 May;13(5):813-817.
Garnero P, Gineyts E, Schaffer AV, Seaman JH, Delmas
PD. Measurement of urinary excretion of nonisomerized
and beta-isomerized forms of type I collagen breakdown
products to monitor the effects of the bisphosphonate
zoledronate in Paget's disease. Arthritis Rheum. 1998
Feb;41(2):354-360.
Eccleshall TR, Garnero P, Gross C, Delmas PD, Feldman
D. Lack of correlation between start codon polymorphism
of the vitamin D receptor gene and bone mineral density
in premenopausal French women: the OFELY study. J
Bone Miner Res. 1998 Jan;13(1):31-35.
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